ajmaline
(17R,21-alpha)-ajmalan-17,21-diol
Identification
| Name | ajmaline |
| CAS Number | 4360-12-7 |
| EINECS | 224-439-4 |
| FDA UNII | 1PON08459R |
| Molecular Formula | C20 H26 N2 O2 |
| Molecular Weight | 326.43962000 |
| MDL Number | MFCD00135652 |
| XlogP3 | 1.80 (est) |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Melting Point | 206.00 °C. @ 760.00 mm Hg |
| Boiling Point | 519.40 °C. @ 760.00 mm Hg (est) |
| Flash Point | 545.00 °F. TCC ( 285.20 °C. ) (est) |
| logP (o/w) | 1.810 |
| Soluble in | water, 490 mg/L @ 30 °C (exp) |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | oral-bird - wild LD50 178 mg/kg |
| Dermal Toxicity | subcutaneous-mouse LD50 180 mg/kg |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements', 'BEHAVIORAL: ATAXIA\nBEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD\nBEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for ajmaline usage levels up to | not for fragrance use. |
| Recommendation for ajmaline flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
ajmalan-17,21-diol
(17R,21-alpha)-
ajmalan-17,21-diol
(17R,21alpha)-
ajmalan-17,21-diol
ajmalan-17,21-diol, (17R,21-alpha)- (9CI)
ajmalan-17,21-diol, (17R,21alpha)-, compound with methanol (1:1)
ajmalin
aritmina
cardiorythmine
cartagine
gilurytmal
ignazin
merabitol
raugalline
rauwolfin
rauwolfine
rhytmaton
ritmos
rytmalin
siddiqui
tachmalin
tajmalin
takhmalin
takycor
PubMed:
Investigation following resuscitated cardiac arrest.
PubMed:
[Studies on predict of absorption of corynanthine, yohimbine, ajmalicine and ajmaline across human intestinal epithelial by using human Caco-2 cells monolayers].
PubMed:
Purification, cloning, functional expression and characterization of perakine reductase: the first example from the AKR enzyme family, extending the alkaloidal network of the plant Rauvolfia.
PubMed:
Structural biology in plant natural product biosynthesis--architecture of enzymes from monoterpenoid indole and tropane alkaloid biosynthesis.
PubMed:
The structure of Rauvolfia serpentina strictosidine synthase is a novel six-bladed beta-propeller fold in plant proteins.
PubMed:
Acetyltransfer in natural product biosynthesis--functional cloning and molecular analysis of vinorine synthase.
PubMed:
Purification and partial amino acid sequences of the enzyme vinorine synthase involved in a crucial step of ajmaline biosynthesis.
PubMed:
In vivo monitoring of alkaloid metabolism in hybrid plant cell cultures by 2D cryo-NMR without labelling.
PubMed:
[Chagasic myocardiopathy: historical perspective].
PubMed:
Inhibitory effects of plant secondary metabolites on cytotoxic activity of polymorphonuclear leucocytes.
PubMed:
[Antiarrhythmic activity of ajmaline obtained from Rauwolfia serpentina biomass grown in tissue culture].
PubMed:
[Clinical and electrophysiological aspects of median intra-His bundle block with normal electrocardiogram at rest].
PubMed:
Usefulness of the ajmaline test in patients with latent bundle branch block.
PubMed:
Unmasking of ventricular preexcitation by vagal stimulation or isoproterenol administration.
PubMed:
Immobilized plant cells for the production and transformation of natural products.