mansonone F
naphtho(1,8-bc)pyran-7,8-dione, 3,6,9-trimethyl- (8CI)(9CI)
Identification
| Name | mansonone F |
| CAS Number | 5090-88-0 |
| FDA UNII | BZI06H42QB |
| Molecular Formula | C15 H12 O3 |
| Molecular Weight | 240.25824000 |
| Nikkaji Number | J13.435J |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Boiling Point | 436.50 °C. @ 760.00 mm Hg (est) |
| Flash Point | 387.00 °F. TCC ( 197.10 °C. ) (est) |
| logP (o/w) | 2.790 (est) |
| Soluble in | water, 91.37 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for mansonone F usage levels up to | not for fragrance use. |
| Recommendation for mansonone F flavor usage levels up to | not for flavor use. |
No supplier data available
Potential Uses
Natural Occurrence
Synonyms
naphtho(1,8-bc)pyran-7,8-dione, 3,6,9-trimethyl- (8CI)(9CI)
3,6,9-
trimethylbenzo[de]chromene-7,8-dione
PubMed:
Design, synthesis and biological evaluation of novel mansonone E derivatives prepared via CuAAC click chemistry as topoisomerase II inhibitors.
PubMed:
Synthesis and evaluation of mansonone F derivatives as topoisomerase inhibitors.
PubMed:
Inhibition of thioredoxin reductase by mansonone F analogues: Implications for anticancer activity.
PubMed:
Alternative procedure for the synthesis of Mansonone F and Biflorin precursor.
PubMed:
The structure-activity relationships of mansonone F, a potent anti-MRSA sesquiterpenoid quinone: SAR studies on the C6 and C9 analogs.
PubMed:
Thespesenone and dehydrooxoperezinone-6-methyl ether, new sesquiterpene quinones from Thespesia populnea.
PubMed:
Syntheses and anti-MRSA activities of the C3 analogs of mansonone F, a potent anti-bacterial sesquiterpenoid: insights into its structural requirements for anti-MRSA activity.
PubMed:
Cytotoxic effects of mansonone E and F isolated from Ulmus pumila.
PubMed:
Isolation of a potent anti-MRSA sesquiterpenoid quinone from Ulmus davidiana var. japonica.
PubMed:
Sesquiterpene O-naphthoquinones from the root bark of Ulmus davidiana.
PubMed:
Effects of mansonones on lipid peroxidation, P450 monooxygenase activity, and superoxide anion generation by rat liver microsomes.