mansonone F

naphtho(1,8-bc)pyran-7,8-dione, 3,6,9-trimethyl- (8CI)(9CI)

CAS: 5090-88-0 C15 H12 O3 MW: 240.25824000

Identification

Namemansonone F
CAS Number5090-88-0
FDA UNIIBZI06H42QB
Molecular FormulaC15 H12 O3
Molecular Weight240.25824000
Nikkaji NumberJ13.435J

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Boiling Point 436.50 °C. @ 760.00 mm Hg (est)
Flash Point 387.00 °F. TCC ( 197.10 °C. ) (est)
logP (o/w) 2.790 (est)
Soluble in water, 91.37 mg/L @ 25 °C (est)

No sensory data available

Safety Information

Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorynatural substances and extractives
Recommendation for mansonone F usage levels up tonot for fragrance use.
Recommendation for mansonone F flavor usage levels up tonot for flavor use.

No supplier data available

Potential Uses

None Found

Natural Occurrence

thespesia populnea

Synonyms

naphtho(1,8-bc)pyran-7,8-dione, 3,6,9-trimethyl- (8CI)(9CI) 3,6,9- trimethylbenzo[de]chromene-7,8-dione PubMed: Design, synthesis and biological evaluation of novel mansonone E derivatives prepared via CuAAC click chemistry as topoisomerase II inhibitors. PubMed: Synthesis and evaluation of mansonone F derivatives as topoisomerase inhibitors. PubMed: Inhibition of thioredoxin reductase by mansonone F analogues: Implications for anticancer activity. PubMed: Alternative procedure for the synthesis of Mansonone F and Biflorin precursor. PubMed: The structure-activity relationships of mansonone F, a potent anti-MRSA sesquiterpenoid quinone: SAR studies on the C6 and C9 analogs. PubMed: Thespesenone and dehydrooxoperezinone-6-methyl ether, new sesquiterpene quinones from Thespesia populnea. PubMed: Syntheses and anti-MRSA activities of the C3 analogs of mansonone F, a potent anti-bacterial sesquiterpenoid: insights into its structural requirements for anti-MRSA activity. PubMed: Cytotoxic effects of mansonone E and F isolated from Ulmus pumila. PubMed: Isolation of a potent anti-MRSA sesquiterpenoid quinone from Ulmus davidiana var. japonica. PubMed: Sesquiterpene O-naphthoquinones from the root bark of Ulmus davidiana. PubMed: Effects of mansonones on lipid peroxidation, P450 monooxygenase activity, and superoxide anion generation by rat liver microsomes.