acetyl carnosine
N-(N-acetyl-b-alanyl)-L-histidine
Identification
| Name | acetyl carnosine |
| IUPAC | (2S)-2-(3-acetamidopropanoylamino)-3-(1H-imidazol-5-yl)propanoic acid |
| CAS Number | 56353-15-2 |
| EINECS | 260-123-2 |
| FDA UNII | 0TPN86OQIF |
| Molecular Formula | C11 H16 N4 O4 |
| Molecular Weight | 268.27332000 |
| MDL Number | MFCD04039376 |
| Nikkaji Number | J296.643C |
| XlogP3 | -1.50 (est) |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Soluble in | water, 3.613e+004 mg/L @ 25 °C (est) |
Cosmetic Information
| CosIng | cosmetic data |
| Cosmetic Uses | skin protecting agents |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | cosmetic ingredient for skin protecting |
| Recommendation for acetyl carnosine usage levels up to | not for fragrance use. |
| Recommendation for acetyl carnosine flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
(2S)-2-(3-
acetamidopropanoylamino)-3-(1H-imidazol-5-yl)propanoic acid
N-(N-
acetyl-b-alanyl)-L-histidine
N-(N-
acetyl-beta-alanyl)-L-histidine
L-
histidine, N-acetyl-b-alanyl-
PubMed:
Individual variability in human blood metabolites identifies age-related differences.
PubMed:
Oxaliplatin complexes with carnosine and its derivatives: in vitro cytotoxicity, mass spectrometric and computational studies with a focus on complex fragmentation.
PubMed:
Salsolinol, a catechol neurotoxin, induces modification of ferritin: Protection by histidine dipeptide.
PubMed:
Inhibitory effect of carnosine and N-acetyl carnosine on LPS-induced microglial oxidative stress and inflammation.
PubMed:
Differential neuroprotective effects of carnosine, anserine, and N-acetyl carnosine against permanent focal ischemia.
PubMed:
[Chaperon-like anticataract agents, the antiaggregants of lens crystallin. Communication 4. Study of the effect of a mixture of di- and tetrapeptides on a prolonged rat model of UV-induced cataract].
PubMed:
[Like anticataract agents, the antiaggregants of lens crystallin. Communication 2. Study of the impact of chaperon-like (protective) activity of short-chain peptides on the rate of UV-induced aggregation of betaL-crystallins by eximer laser].
PubMed:
[Search for chaperon-like anticataract drugs, the antiaggregants of lens crystallins. Communication. 1. Chaperon-like activity of N-acetyl carnosine dipeptide: in vitro study on a model of ultraviolet-induced aggregation of betaL-crystallin].
PubMed:
The effect of a topical antioxidant formulation including N-acetyl carnosine on canine cataract: a preliminary study.
PubMed:
Carnosine is a quencher of 4-hydroxy-nonenal: through what mechanism of reaction?
PubMed:
Effects of carnosine and related compounds on the stability and morphology of erythrocytes from alcoholics.
PubMed:
[Effect of carnosine and its N-acetyl derivative on the stability of erythrocytes in patients with alcoholism during abstinence].