laevo-aspartic acid
L-aspartic acid
Identification
| Name | laevo-aspartic acid |
| IUPAC | (2S)-2-aminobutanedioic acid |
| CAS Number | 56-84-8 |
| EINECS | 200-291-6 |
| FDA UNII | 30KYC7MIAI |
| Molecular Formula | C4 H7 N O4 |
| Molecular Weight | 133.10359000 |
| MDL Number | MFCD00002616 |
| Nikkaji Number | J9.169C |
| Beilstein | 1723530 |
| CoE Number | 10078 |
| XlogP3 | -2.80 (est) |
Regulatory
| JECFA Food Flavoring | 1429 L-aspartic acid |
| DG SANTE Food Flavourings | 17.005 L-aspartic acid |
| FEMA Number | 3656 |
| FDA | No longer provide for the use of these seven synthetic flavoring substances |
| FDA Mainterm (SATF) | 56-84-8 ; L-ASPARTIC ACID |
| FDA Regulation | FDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION |
Physical Properties
| Appearance | white crystalline powder (est) |
| Assay | 98.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Melting Point | 270.00 °C. @ 760.00 mm Hg |
| Boiling Point | 263.00 to 264.00 °C. @ 760.00 mm Hg |
| PH Number | 2.80 |
| Vapor Pressure | 0.003000 mmHg @ 25.00 °C. (est) |
| Flash Point | 236.00 °F. TCC ( 113.33 °C. ) |
| logP (o/w) | -3.890 |
| Soluble in | propylene glycol |
| Insoluble in | water |
Cosmetic Information
| CosIng | cosmetic data |
| Cosmetic Uses | antistatic agents |
Organoleptic Properties
| Odor Strength | none |
| Odor Description | at 100.00 %. |
| Odor sample from | Sigma-Aldrich |
| Taste Description | acid |
Safety Information
| Preferred SDS | View |
| European information | Most important hazard(s): |
| Oral/Parenteral Toxicity | intraperitoneal-mouse LD50 6000 mg/kg |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | special dietary and nutritional additives |
| Recommendation for laevo-aspartic acid usage levels up to | not for fragrance use. |
| Maximised Survey-derived Daily Intakes (MSDI-EU) | 68.00 (μg/capita/day) |
| baked goods | - |
| beverages(nonalcoholic) | - |
| beverages(alcoholic) | - |
| breakfast cereal | - |
| cheese | - |
| chewing gum | - |
| condiments / relishes | - |
| confectionery froastings | - |
| egg products | - |
| fats / oils | - |
| fish products | - |
| frozen dairy | - |
| fruit ices | - |
| gelatins / puddings | - |
| granulated sugar | - |
| gravies | - |
| hard candy | - |
| imitation dairy | - |
| instant coffee / tea | - |
| jams / jellies | - |
| meat products | - |
| milk products | - |
| nut products | - |
| other grains | - |
| poultry | - |
| processed fruits | - |
| processed vegetables | - |
| reconstituted vegetables | - |
| seasonings / flavors | - |
| snack foods | - |
| soft candy | - |
| soups | - |
| sugar substitutes | - |
| sweet sauces | - |
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Potential Uses
Natural Occurrence
Synonyms
acide L-aspartique
(S)-
amino-butanedioic acid
(S)-
aminobutane dioic acid
2-
aminobutane doic acid
(2S)-2-
aminobutanedioic acid
(S)-
aminobutanedioic acid
(S)-2-
aminobutanedioic acid
L-2-
aminobutanedioic acid
(2S)-2-
aminosuccinic acid
(S)-2-
aminosuccinic acid
L-
aminosuccinic acid
aspara K
asparagic acid
L-
asparagic acid
(S)-
asparaginic acid
L-
asparaginic acid
(+)-
aspartic acid
(2S)-
aspartic acid
(L)-
aspartic acid
(S)-
aspartic acid
(S)-(+)-
aspartic acid
L-
aspartic acid
L-(+)-
aspartic acid
S-
aspartic acid
L-
aspartic acid FCC
aspartic acid L-
aspartic acid, L-
L-
asparticacid
aspatofort
butanedioic acid, amino-, (S)-
calciretard
K-flebo
PubMed:
Umami evaluation in taste epithelium on microelectrode array by extracellular electrophysiological recording.
PubMed:
Aspartame--a sweet surprise.
PubMed:
A 'conovenomic' analysis of the milked venom from the mollusk-hunting cone snail Conus textile--the pharmacological importance of post-translational modifications.
PubMed:
Umami evaluation in taste epithelium on microelectrode array by extracellular electrophysiological recording.
PubMed:
Canthaxanthin production with modified Mucor circinelloides strains.
PubMed:
Leishmania donovani argininosuccinate synthase is an active enzyme associated with parasite pathogenesis.
PubMed:
Fast determination of N-phenylpropenoyl-l-amino acids (NPA) in cocoa samples from different origins by ultra-performance liquid chromatography and capillary electrophoresis.
PubMed:
Catalytic mechanisms and biocatalytic applications of aspartate and methylaspartate ammonia lyases.
PubMed:
Demetalation of Fe, Mn, and Cu chelates and complexes: application to the NMR analysis of micronutrient fertilizers.
PubMed:
Pharmacokinetics and metabolism of N-[N-[3-(3-hydroxy-4-methoxyphenyl) propyl]-α-aspartyl]-L-phenylalanine 1-methyl ester, monohydrate (advantame) in the rat, dog, and man.
PubMed:
Two-generation reproductive and developmental toxicity assessment of dietary N-acetyl-L-aspartic acid in rats.
PubMed:
Subchronic oral toxicity assessment of N-acetyl-L-aspartic acid in rats.
PubMed:
Effect of media, additives, and incubation conditions on the recovery of high pressure and heat-injured Clostridium botulinum spores.
PubMed:
Comparison of genotypes of Salmonella enterica serovar Enteritidis phage type 30 and 9c strains isolated during three outbreaks associated with raw almonds.
PubMed:
Acute oral toxicity of N-acetyl-L-aspartic acid (NAA) in rats.
PubMed:
Control of impurities in L-aspartic acid and L-alanine by high-performance liquid chromatography coupled with a corona charged aerosol detector.
PubMed:
Identification of genetic and phenotypic differences associated with prevalent and non-prevalent Salmonella Enteritidis phage types: analysis of variation in amino acid transport.
PubMed:
Mutagenicity studies with N-acetyl-L-aspartic acid.
PubMed:
Absorption of N-phenylpropenoyl-L-amino acids in healthy humans by oral administration of cocoa (Theobroma cacao).
PubMed:
Toxic effects of l-aspartic acid at high dose levels on kidneys and salivary glands in Fischer 344 rats detected in a 90-day feeding study.
PubMed:
Acute and repeated dose oral toxicity of N-acetyl-l-aspartic acid in Sprague-Dawley rats.
PubMed:
Formation of diacetyl and acetoin by Lactococcus lactis via aspartate catabolism.
PubMed:
Aspartate biosynthesis is essential for the growth of Streptococcus thermophilus in milk, and aspartate availability modulates the level of urease activity.
PubMed:
Luteimonas composti sp. nov., a moderately thermophilic bacterium isolated from food waste.
PubMed:
Potential use of biodegradable chelate N-(1,2-dicarboxyethyl)-D,L-aspartic acid/Fe3+ as an Fe fertilizer.
PubMed:
Quantitative analysis of N-phenylpropenoyl-L-amino acids in roasted coffee and cocoa powder by means of a stable isotope dilution assay.
PubMed:
Quantitative studies, taste reconstitution, and omission experiments on the key taste compounds in morel mushrooms (Morchella deliciosa Fr.).
PubMed:
A new method of age estimation based on the changes in human non-collagenous proteins from dentin.
PubMed:
Anticholesterolemic effect of 3,4-di(OH)-phenylpropionic amides in high-cholesterol fed rats.
PubMed:
Isolation, structure determination, synthesis, and sensory activity of N-phenylpropenoyl-L-amino acids from cocoa (Theobroma cacao).
PubMed:
Sensory-guided decomposition of roasted cocoa nibs (Theobroma cacao) and structure determination of taste-active polyphenols.
PubMed:
Activity-guided identification of (S)-malic acid 1-O-D-glucopyranoside (morelid) and gamma-aminobutyric acid as contributors to umami taste and mouth-drying oral sensation of morel mushrooms (Morchella deliciosa Fr.).
PubMed:
Application of stepwise discriminant analysis to classify commercial orange juices using chiral micellar electrokinetic chromatography-laser induced fluorescence data of amino acids.
PubMed:
Monohydroxamates of aspartic acid and glutamic acid exhibit antioxidant and angiotensin converting enzyme inhibitory activities.
PubMed:
Industrial production of amino acids by coryneform bacteria.
PubMed:
A novel inhibitor of beta-glucuronidase: L-aspartic acid.
PubMed:
Formation of Pentylpyridines in an Oil Medium.
PubMed:
Aspartate dehydrogenase in vitamin B12-producing Klebsiella pneumoniae IFO 13541.
PubMed:
Effects of estradiol and exogenous insulin-like growth factor I (IGF-I) on the IGF-I axis during growth hormone inhibition and antagonism.
PubMed:
Evaluation of D-amino acid levels in rat by gas chromatography-selected ion monitoring mass spectrometry: no evidence for subacute toxicity of orally fed D-proline and D-aspartic acid.
PubMed:
Fasting-induced suppression of hypothalamic-pituitary-gonadal axis in the adult rhesus monkey: evidence for involvement of excitatory amino acid neurotransmitters.
PubMed:
Kinetic analysis of glutamate transport by the miniswine choroid plexus in vitro.
PubMed:
Long-term continuous synthesis of aspartame precursor in a column reactor with an immobilized thermolysin.
PubMed:
Aspartame intolerance.
PubMed:
The inhibition by morphine and D-aspartic acid of antibody production against Salmonella typhimurium antigen in rats: its antagonism by L-aspartic acid.
PubMed:
Mutagenicity studies on N-nitrosated products of the Maillard browning reaction: N-nitroso-fructose-amino acids.
PubMed:
Feeding, drinking, urine osmolality in DI Brattleboro rats: changes by morphine, naloxone, D-amino acids, prolyl-leucyl-glycinamide (PLG).