laevo-histidine
L-histidine
Identification
| Name | laevo-histidine |
| CAS Number | 71-00-1 |
| EINECS | 200-745-3 |
| FDA UNII | 4QD397987E |
| Molecular Formula | C6 H9 N3 O2 |
| Molecular Weight | 155.15713000 |
| MDL Number | MFCD00064315 |
| Nikkaji Number | J4.881J |
| Beilstein | 0084088 |
| CoE Number | 17008 |
Regulatory
| JECFA Food Flavoring | 1431 L-histidine |
| DG SANTE Food Flavourings | 17.008 L-histidine |
| FEMA Number | 3694 |
| FDA | No longer provide for the use of these seven synthetic flavoring substances |
| FDA Mainterm (SATF) | 71-00-1 ; L-HISTIDINE |
| FDA Regulation | FDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION |
Physical Properties
| Appearance | white crystalline powder (est) |
| Food Chemicals Codex Listed | No |
| Melting Point | 282.00 to 287.00 °C. @ 760.00 mm Hg |
| Boiling Point | 458.87 °C. @ 760.00 mm Hg (est) |
| Flash Point | 448.00 °F. TCC ( 231.11 °C. ) |
| logP (o/w) | -1.418 (est) |
| Soluble in | water, 4.193e+005 mg/L @ 25 °C (est) |
Cosmetic Information
| CosIng | cosmetic data |
| Cosmetic Uses | antistatic agents |
Organoleptic Properties
| Odor Strength | none |
| Odor Description | at 100.00 %. |
Safety Information
| Preferred SDS | View |
| European information | Most important hazard(s): |
| Oral/Parenteral Toxicity | intraperitoneal-rat LD50 > 8000 mg/kg |
| Dermal Toxicity | subcutaneous-mouse LD50 > 10000 mg/kg |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | special dietary and nutritional additives |
| Recommendation for laevo-histidine usage levels up to | not for fragrance use. |
| Maximised Survey-derived Daily Intakes (MSDI-EU) | 9.50 (μg/capita/day) |
| baked goods | 10.00000 |
| beverages(nonalcoholic) | 200.00000 |
| beverages(alcoholic) | - |
| breakfast cereal | - |
| cheese | - |
| chewing gum | - |
| condiments / relishes | - |
| confectionery froastings | 20.00000 |
| egg products | - |
| fats / oils | - |
| fish products | - |
| frozen dairy | - |
| fruit ices | - |
| gelatins / puddings | - |
| granulated sugar | - |
| gravies | - |
| hard candy | - |
| imitation dairy | - |
| instant coffee / tea | - |
| jams / jellies | - |
| meat products | 30.00000 |
| milk products | 10.00000 |
| nut products | - |
| other grains | - |
| poultry | - |
| processed fruits | - |
| processed vegetables | - |
| reconstituted vegetables | - |
| seasonings / flavors | - |
| snack foods | - |
| soft candy | - |
| soups | - |
| sugar substitutes | - |
| sweet sauces | - |
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Potential Uses
Natural Occurrence
Synonyms
L-
alanine, 3-(1H-imidazol-4-yl)-
(S)-a-
amino-1H-imidazole-4-propanoic acid
(S)-alpha-
amino-1H-imidazole-4-propanoic acid
(S)-a-
amino-1H-imidazole-4-propionic acid
a-
amino-1H-imidazole-4-propionic acid, (S)-
(S)-4-(2-
amino-2-carboxyethyl) imidazole
(2S)-2-
amino-3-(1H-imidazol-4-yl)propanoic acid
(2S)-2-
amino-3-(1H-imidazol-5-yl)propanoic acid
(S)-2-
amino-3-(4-imidazolyl) propionsaeure
(S)-2-
amino-3-(4-imidazolyl)propionic acid
L-(+)-2-
amino-3-(4-imidazolyl)propionic acid
2-
amino-3,4-imidazyl propionic acid
2-
amino-3(4-imidasyl)propionic acid
alpha-
amino-4-imidazole propionic acid
alpha-
amino-4(or 5)-imidazole propionic acid
a-
amino-4(or 5)-imidazolepropionic acid
glyoxaline-5-alanine
(L)-
histidine
(S)-
histidine
L-
histidine
L-(-)-
histidine
S-
histidine
L-
histidine base
L-
histidine base natural
histidine, L-
hydrogen L-histidinate
3-(1H-
imidazol-4-yl)-L-alanine
(S)-1H-
imidazole-4-alanine
1H-
imidazole-4-alanine, (S)-
1H-
imidazole-4-propanoic acid, a-amino-, (S)-
L-beta-(4-
imidazolyl)-alpha-alanin
laevo-beta-(4-
imidazolyl)-alpha-alanin
plexamine
PubMed:
Biological functions of histidine-dipeptides and metabolic syndrome.
PubMed:
EPR spectroscopy of a clinically active (1:2) copper(II)-histidine complex used in the treatment of Menkes disease: a Fourier transform analysis of a fluid CW-EPR spectrum.
PubMed:
pH-Sensitive nano-systems for drug delivery in cancer therapy.
PubMed:
Chiral separation-based ligand exchange by open-tubular capillary electrochromatography.
PubMed:
A 'conovenomic' analysis of the milked venom from the mollusk-hunting cone snail Conus textile--the pharmacological importance of post-translational modifications.
PubMed:
A novel amperometric biosensor based on a co-crosslinked L-lysine-α-oxidase/overoxidized polypyrrole bilayer for the highly selective determination of L-lysine.
PubMed:
Hydrolysis of wheat gluten by combining peptidases of Flammulina velutipes and electrodialysis.
PubMed:
Determination and frying loss of histamine in striped marlin fillets implicated in a foodborne poisoning.
PubMed:
Effect of metformin on the urinary metabolites of diet-induced-obese mice studied by ultra performance liquid chromatography coupled to time-of-flight mass spectrometry (UPLC-TOF/MS).
PubMed:
L-carnosine modulates respiratory burst and reactive oxygen species production in neutrophil biochemistry and function: may oral dosage form of non-hydrolized dipeptide L-carnosine complement anti-infective anti-influenza flu treatment, prevention and self-care as an alternative to the conventional vaccination?
PubMed:
Preparation and use of poly(hydroxyethyl methacrylate) cryogels containing L-histidine for β-casein adsorption.
PubMed:
Characterization of ergothionase from Burkholderia sp. HME13 and its application to enzymatic quantification of ergothioneine.
PubMed:
Biogenic amine content, histamine-forming bacteria, and adulteration of pork in tuna sausage products.
PubMed:
Safety of a probiotic cheese containing Lactobacillus plantarum Tensia according to a variety of health indices in different age groups.
PubMed:
GC-MS based metabolomics for rapid simultaneous detection of Escherichia coli O157:H7, Salmonella Typhimurium, Salmonella Muenchen, and Salmonella Hartford in ground beef and chicken.
PubMed:
Olfactory dysfunction and cognitive impairment in age-related neurodegeneration: prevalence related to patient selection, diagnostic criteria and therapeutic treatment of aged clients receiving clinical neurology and community-based care.
PubMed:
Gelatin enhances 2-keto-L-gulonic acid production based on Ketogulonigenium vulgare genome annotation.
PubMed:
Sensory-guided identification of N-(1-methyl-4-oxoimidazolidin-2-ylidene)-alpha-amino acids as contributors to the thick-sour and mouth-drying orosensation of stewed beef juice.
PubMed:
The bioactive dipeptide anserine is transported by human proton-coupled peptide transporters.
PubMed:
Sensory-directed identification of beta-alanyl dipeptides as contributors to the thick-sour and white-meaty orosensation induced by chicken broth.
PubMed:
Identification of genetic and phenotypic differences associated with prevalent and non-prevalent Salmonella Enteritidis phage types: analysis of variation in amino acid transport.
PubMed:
Kokumi-active glutamyl peptides in cheeses and their biogeneration by Penicillium roquefortii.
PubMed:
Intestinal absorption and blood clearance of L-histidine-related compounds after ingestion of anserine in humans and comparison to anserine-containing diets.
PubMed:
L-histidine enhances learning in stressed zebrafish.
PubMed:
Protein properties of mackerel viscera extracted by supercritical carbon dioxide.
PubMed:
Iron (III) porphyrin bearing 2,6-di-tert-butylphenol pendants deposited onto gold electrodes for amperometric determination of L-histidine.
PubMed:
Carnosine [corrected] increases efficiency of DOPA therapy of Parkinson's disease: a pilot study.
PubMed:
Fast and simultaneous detection of heavy metals using a simple and reliable microchip-electrochemistry route: An alternative approach to food analysis.
PubMed:
Radical acetylation of 2'-deoxyguanosine and L-histidine coupled to the reaction of diacetyl with peroxynitrite in aerated medium.
PubMed:
Effects of Maillard reaction products on hilA expression in Salmonella typhimurium.
PubMed:
Nalpha-(1-deoxy-D-fructos-1-yl)-L-histidine ("D-Fructose-L-histidine"): a potent copper chelator from tomato powder.
PubMed:
Amino acid and carbohydrate preferences in C57BL/6ByJ and 129P3/J mice.
PubMed:
Fasting-induced changes in ECL cell gene expression.
PubMed:
Involvement of the histaminergic system on appetitive learning and its interaction with haloperidol in goldfish.
PubMed:
Carnosine concentration of ingested meat affects carnosine net release into the portal vein of minipigs.
PubMed:
Food components inhibiting recombinant human histidine decarboxylase activity.
PubMed:
Solubility and crystal structure of N-(1-deoxy-beta-D-fructopyranos-1-yl)-l-histidine monohydrate ('D-fructose-l-histidine').
PubMed:
Purification and characterization of a halotolerant intracellular protease from Bacillus subtilis strain FP-133.
PubMed:
Interactions between carnosine and captopril on free radical scavenging activity and angiotensin-converting enzyme activity in vitro.
PubMed:
Histidine intake may negatively correlate with energy intake in human: a cross-sectional study in Japanese female students aged 18 years.
PubMed:
Pyrolytic acrylamide formation from purified wheat gluten and gluten-supplemented wheat bread rolls.
PubMed:
Effects of non-ionic surfactants on isotachophoretic separations of 2-arylpropionic acids.
PubMed:
Quantitation of carnosine in humans plasma after dietary consumption of beef.
PubMed:
Development of a whole-cell-based biosensor for detecting histamine as a model toxin.
PubMed:
Effect of central administration of carnosine and its constituents on behaviors in chicks.
PubMed:
Effects of cyclo (his-pro) plus zinc on glucose metabolism in genetically diabetic obese mice.
PubMed:
Inhibition of diphenolase activity of tyrosinase by vitamin b(6) compounds.
PubMed:
Neuronal storage of histamine in the brain and tele-methylimidazoleacetic acid excretion in portocaval shunted rats.
PubMed:
Histidine suppresses food intake through its conversion into neuronal histamine.
PubMed:
In vitro and in vivo inhibition of muscle lipid and protein oxidation by carnosine.
PubMed:
Role of central histaminergic system in lorazepam withdrawal syndrome in rats.
PubMed:
The histaminergic system in the brain: structural characteristics and changes in hibernation.
PubMed:
Influence of dietary β-alanine and histidine on the oxidative stability of pork.
PubMed:
Response of rainbow trout (Oncorhynchus mykiss) to supplements of individual essential amino acids in a semipurified diet, including an estimate of the maintenance requirement for essential amino acids.
PubMed:
[The characteristics of parenteral feeding in patients with kidney failure].
PubMed:
Long-term toxicity/carcinogenicity study of L-histidine monohydrochloride in F344 rats.
PubMed:
Studies on the formation of lysinomethylalanine and histidinomethylalanine in milk products.
PubMed:
The significance of apical K+ channels in mudpuppy feeding behavior.
PubMed:
[13-week subchronic toxicity study of L-histidine monohydrochloride in F344 rats].
PubMed:
Human urinary excretion of L-histidine-related compounds after ingestion of several meats and fish muscle.
PubMed:
Detection and identification of the cross-linking amino acids N tau- and N pi-(2'-amino-2'-carboxy-ethyl)-L-histidine ("histidinoalanine", HAL) in heated milk products.
PubMed:
Measurement and characterization of histamine and methylhistamine in human urine under histamine-rich and histamine-poor diets.
PubMed:
Interorgan transport and catabolism of carnosine and anserine in rainbow trout.
PubMed:
Changes in histamine metabolism in the brains of mice with streptozotocin-induced diabetes.
PubMed:
Comparative effects of individual amino acid excesses when added to a corn-soybean meal diet: effects on growth and dietary choice in the chick.
PubMed:
Differential effect of total food withdrawal and dietary protein restriction on brain content of free histidine in the rat.
PubMed:
Practical observations on the methodology for determining 3-methyl-l-histidine using fluorescamine derivatives.
PubMed:
Variations in the levels of 3-methyl-l-histidine of the myosins within the bovine carcass.
PubMed:
The effect of L-histidine on acute cobalt intoxication in rats.
PubMed:
Effect of zinc deficiency on histidine metabolism in rats.
PubMed:
Intestinal transport of amino acids in protein-deficient rats and the effect of rehabilitation using a casein diet.
PubMed:
Production of oxytetracycline by Streptomyces rimosus 12,907 as an animal feed supplement.
PubMed:
Failure of oral L-histidine to influence appetite or affect zinc metabolism in man: a double-blind study.
PubMed:
In-vitro studies on intestinal malabsorption of amino-acids in young chicks infected with Eimeria acervulina.
PubMed:
Further studies on intestinal active transport during semistarvation.
PubMed:
Olfactory dysfunction and cognitive impairment in age-related neurodegeneration: prevalence related to patient selection, diagnostic criteria and therapeutic treatment of aged clients receiving clinical neurology and community-based care.