apo-lactoferrin

apolactoferrin iron-depleted form of Lactoferrin PubMed: Potential of lactoferrin to prevent antibiotic-induced Clostridium difficile infection. PubMed: Combined effects of lactoferrin and lysozyme on Streptococcus pneumoniae killing. PubMed: Antiviral activities of whey proteins. PubMed: Lactoferrin-loaded contact lenses: eye protection against oxidative stress. PubMed: A Moraxella catarrhalis two-component signal transduction system necessary for growth in liquid media affects production of two lysozyme inhibitors. PubMed: The structure of lactoferrin-binding protein B from Neisseria meningitidis suggests roles in iron acquisition and neutralization of host defences. PubMed: Identification of unprecedented anticancer properties of high molecular weight biomacromolecular complex containing bovine lactoferrin (HMW-bLf). PubMed: Effect of bovine apo-lactoferrin on the growth and virulence of Actinobacillus pleuropneumoniae. PubMed: Structure of the iron-free true C-terminal half of bovine lactoferrin produced by tryptic digestion and its functional significance in the gut. PubMed: Lactoferrin directly scavenges hydroxyl radicals and undergoes oxidative self-degradation: a possible role in protection against oxidative DNA damage. PubMed: Retention of structure, antigenicity, and biological function of pneumococcal surface protein A (PspA) released from polyanhydride nanoparticles. PubMed: A high-throughput method for the quantification of iron saturation in lactoferrin preparations. PubMed: Selenium compound protects corneal epithelium against oxidative stress. PubMed: Human apo-lactoferrin as a physiological mimetic of hypoxia stabilizes hypoxia-inducible factor-1 alpha. PubMed: The transfer of iron between ceruloplasmin and transferrins. PubMed: Apo- and holo-lactoferrin stimulate proliferation of mouse crypt cells but through different cellular signaling pathways. PubMed: Apo- and holo-lactoferrin are both internalized by lactoferrin receptor via clathrin-mediated endocytosis but differentially affect ERK-signaling and cell proliferation in Caco-2 cells. PubMed: Lactoferrin inhibits neutrophil apoptosis via blockade of proximal apoptotic signaling events. PubMed: Serine protease PrtA from Streptococcus pneumoniae plays a role in the killing of S. pneumoniae by apolactoferrin. PubMed: Effect of apolactoferrin on experimental pneumococcal otitis media. PubMed: Effect of bovine lactoferrin addition to milk in yogurt manufacturing. PubMed: Use and endocytosis of iron-containing proteins by Entamoeba histolytica trophozoites. PubMed: 28-Day repeated dose oral toxicity of recombinant human apo-lactoferrin or recombinant human lysozyme in rats. PubMed: IsdA protects Staphylococcus aureus against the bactericidal protease activity of apolactoferrin. PubMed: Thiophilic interaction chromatography of mammalian and avian transferrins. PubMed: Apolactoferrin inhibits the catalytic domain of matrix metalloproteinase-2 by zinc chelation. PubMed: Amoebicidal activity of milk, apo-lactoferrin, sIgA and lysozyme. PubMed: Capsule does not block antibody binding to PspA, a surface virulence protein of Streptococcus pneumoniae. PubMed: Human hololactoferrin: endocytosis and use as an iron source by the parasite Entamoeba histolytica. PubMed: PspA protects Streptococcus pneumoniae from killing by apolactoferrin, and antibody to PspA enhances killing of pneumococci by apolactoferrin [corrected]. PubMed: Growth-promoting effects of lactoferrin on L. acidophilus and Bifidobacterium spp. PubMed: Lactoferrin and iron: structural and dynamic aspects of binding and release. PubMed: Human apo-lactoferrin enhances angiogenesis mediated by vascular endothelial growth factor A in vivo. PubMed: In vivo effects of bifidobacteria and lactoferrin on gut endotoxin concentration and mucosal immunity in Balb/c mice. PubMed: Tertiary structural changes associated with iron binding and release in hen serum transferrin: a crystallographic and spectroscopic study. PubMed: In vitro growth responses of bifidobacteria and enteropathogens to bovine and human lactoferrin. PubMed: In vitro characterization of lactoferrin aggregation and amyloid formation. PubMed: Lactoferrin in the preterm infants' diet attenuates iron-induced oxidation products. PubMed: Lactoferrin iron levels affect attachment of Actinobacillus actinomycetemcomitans to buccal epithelial cells. PubMed: Crystal structure of equine apolactoferrin at 303 K providing further evidence of closed conformations of N and C lobes. PubMed: Involvement of bovine lactoferrin metal saturation, sialic acid and protein fragments in the inhibition of rotavirus infection. PubMed: Protein intermediate trapped by the simultaneous crystallization process. Crystal structure of an iron-saturated intermediate in the Fe3+ binding pathway of camel lactoferrin at 2.7 a resolution. PubMed: Camel lactoferrin, a transferrin-cum-lactoferrin: crystal structure of camel apolactoferrin at 2.6 A resolution and structural basis of its dual role. PubMed: Inhibitory effect of lactoferrin on the adhesion of Prevotella nigrescens ATCC 25261 to hydroxyapatite. PubMed: Transferrins: iron release from lactoferrin. PubMed: Metal complexes of lactoferrin and their effect on the intracellular multiplication of Legionella pneumophila. PubMed: Structure of mare apolactoferrin: the N and C lobes are in the closed form. PubMed: Structure of human apolactoferrin at 2.0 A resolution. Refinement and analysis of ligand-induced conformational change. addendum PubMed: Structure of human apolactoferrin at 2.0 A resolution. Refinement and analysis of ligand-induced conformational change. PubMed: Growth responses of coliform bacteria to purified immunoglobulin G from cows immunized with ferric enterobactin receptor FepA. PubMed: Antiviral effect of bovine lactoferrin saturated with metal ions on early steps of human immunodeficiency virus type 1 infection. PubMed: Bovine lactoferrin and Lactoferricin inhibit tumor metastasis in mice. PubMed: Ligand-induced conformational change in transferrins: crystal structure of the open form of the N-terminal half-molecule of human transferrin. PubMed: Synergic antistaphylococcal properties of lactoferrin and lysozyme. PubMed: Transferrins--a mechanism for iron uptake by lactoferrin. PubMed: The pH-induced release of iron from transferrin investigated with a continuum electrostatic model. PubMed: Inhibition of in vitro growth of coliform bacteria by a monoclonal antibody directed against ferric enterobactin receptor FepA. PubMed: Antirotaviral activity of milk proteins: lactoferrin prevents rotavirus infection in the enterocyte-like cell line HT-29. PubMed: The antifungal effect of lactoferrin and lysozyme on Candida krusei and Candida albicans. PubMed: An estrogen inducible 104 kDa chaperone glycoprotein binds ferric iron containing proteins: a possible role in intracellular iron trafficking. PubMed: Human lactoferrin receptor activity in non-encapsulated Haemophilus influenzae. PubMed: Transferrin--interactions of lactoferrin with hydrogen carbonate. PubMed: Augmented inhibition of growth of Candida albicans by neutrophils in the presence of lactoferrin. PubMed: Relationship between antibacterial activity and cell surface binding of lactoferrin in species of genus Micrococcus. PubMed: Bovine lactoferrin and lactoferricin, a peptide derived from bovine lactoferrin, inhibit tumor metastasis in mice. PubMed: Lactoferrin as a suppressor of cell migration of gastrointestinal cell lines. PubMed: Compact growth of Staphylococcus haemolyticus in soft agar is not due to hydrophobic interaction between the cocci. PubMed: Antibacterial activity of peptides homologous to a loop region in human lactoferrin. PubMed: Immobilized metal ion affinity chromatography. PubMed: Growth inhibitory effects of bovine lactoferrin to Toxoplasma gondii parasites in murine somatic cells. PubMed: Preparation of apolactoferrin with a very low iron saturation. PubMed: Modulation of the anti-Candida activity of apo-lactoferrin by dietary sucrose and tunicamycin in vitro. PubMed: The effect of antifungal agents on the in vitro susceptibility of Candida albicans to apo-lactoferrin. PubMed: Acquisition of iron from transferrin and lactoferrin by the protozoan Leishmania chagasi. PubMed: Iron-induced conformational change in human lactoferrin: demonstration by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and analysis of effects of iron binding to the N and C lobes of the molecule. PubMed: Protein-binding Properties of two Antitumour Ru(III) Complexes to Human Apotransferrin and Apolactoferrin. PubMed: Kinetic parameters for the heat denaturation of bovine lactoferrin in milk, and its effect on interaction with monocytes. PubMed: A comparison of the three-dimensional structures of human lactoferrin in its iron free and iron saturated forms. PubMed: Antimicrobial peptides of lactoferrin. PubMed: Three-dimensional structure of lactoferrin in various functional states. PubMed: Proposed mechanisms for the involvement of lactoferrin in the hydrolysis of nucleic acids. PubMed: The fungicidal effect of human lactoferrin on Candida albicans and Candida krusei. PubMed: Thermal behavior of bovine lactoferrin in water and its relation to bacterial interaction and antibacterial activity. PubMed: Iron binding to human lactoferrin alters reactivity of the protein with plant lectins. PubMed: Forms of lactoferrin: their antibacterial effect on enterotoxigenic Escherichia coli. PubMed: Effect of heat treatment and other milk proteins on the interaction of lactoferrin with monocytes. PubMed: Influence of lactoferrin on the entry process of Escherichia coli HB101 (pRI203) in HeLa cells. PubMed: Agglutination of Streptococcus mutans serotype C cells but inhibition of Porphyromonas gingivalis autoaggregation by human lactoferrin. PubMed: Nitric oxide interaction with lactoferrin and its production by macrophage cells studied by EPR and spin trapping. PubMed: Preliminary crystallographic studies of the amino terminal half of human lactoferrin in its iron-saturated and iron-free forms. PubMed: Interaction of lactoferrin and lipopolysaccharide (LPS): effects on the antioxidant property of lactoferrin and the ability of LPS to prime human neutrophils for enhanced superoxide formation. PubMed: High-performance liquid chromatographic separation of human apolactoferrin and monoferric and diferric lactoferrins. PubMed: Different profiles of induced cotton effects of human and bovine lactoferrin by cibacron blue F3GA binding. PubMed: Effect of transferrin, lactoferrin and chelated iron on human T-lymphocytes. PubMed: Apotransferrins from several species promote thyroid hormone-dependent rat pituitary tumor cell growth in iron-restricted serum-free defined culture. PubMed: Fungicidal effect of human lactoferrin against Candida albicans. PubMed: Uptake of lactoferrin by mononuclear phagocytes inhibits their ability to form hydroxyl radical and protects them from membrane autoperoxidation. PubMed: Binding and endocytosis of apo- and holo-lactoferrin by isolated rat hepatocytes. PubMed: Molecular replacement solution of the structure of apolactoferrin, a protein displaying large-scale conformational change. PubMed: Lactoferrin inhibits or promotes Legionella pneumophila intracellular multiplication in nonactivated and interferon gamma-activated human monocytes depending upon its degree of iron saturation. Iron-lactoferrin and nonphysiologic iron chelates reverse monocyte activation against Legionella pneumophila. PubMed: Pseudomonas and neutrophil products modify transferrin and lactoferrin to create conditions that favor hydroxyl radical formation. PubMed: Structure, function and flexibility of human lactoferrin. PubMed: Metal ligand-induced alterations in the surface structures of lactoferrin and transferrin probed by interaction with immobilized copper(II) ions. PubMed: Prooxidant activity of transferrin and lactoferrin. PubMed: Iron is not required in the lactoferrin stimulation of thymidine incorporation into the DNA of rat crypt enterocytes. PubMed: Apolactoferrin structure demonstrates ligand-induced conformational change in transferrins. PubMed: Differential interaction of peptides and protein surface structures with free metal ions and surface-immobilized metal ions. PubMed: Growth of gram-negative bacteria in dry cow secretion. PubMed: Interaction of lactoferrin with Escherichia coli cells and correlation with antibacterial activity. PubMed: Rapid purification of porcine colostral whey lactoferrin by affinity chromatography on single-stranded DNA-agarose. Characterization, amino acid composition and N-terminal amino acid sequence. PubMed: Interaction of human lactoferrin with DNA: one-step purification by affinity chromatography on single-stranded DNA-agarose. PubMed: Preliminary crystallographic studies on human apo-lactoferrin in its native and deglycosylated forms. PubMed: Growth and adsorption of Streptococcus mutans 6715-13 to hydroxyapatite in the presence of lactoferrin. PubMed: The superoxide-dependent transfer of iron from ferritin to transferrin and lactoferrin. PubMed: Characterization of the human transferrin and lactoferrin receptors in Haemophilus influenzae. PubMed: Identification and characterization of the human lactoferrin-binding protein from Neisseria meningitidis. PubMed: Susceptibilities of lactoferrin and transferrin to myeloperoxidase-dependent loss of iron-binding capacity. PubMed: Iron metabolism in BeWo chorion carcinoma cells. Transferrin-mediated uptake and release of iron. PubMed: Superoxide-dependent and ascorbate-dependent formation of hydroxyl radicals from hydrogen peroxide in the presence of iron. Are lactoferrin and transferrin promoters of hydroxyl-radical generation? PubMed: Bactericidal effect of lactoferrin on Legionella pneumophila. PubMed: In vitro growth of mastitis-associated streptococci in bovine mammary secretions. PubMed: Effect of iron chelators on the transferrin receptor in K562 cells. PubMed: Evidence for a role of hydroxyl radical in immune-complex-induced vasculitis. PubMed: Inhibition of mastitic bacteria by bovine milk apo-lactoferrin evaluated by in vitro microassay of bacterial growth. PubMed: Kinetic effect of human lactoferrin on the growth of Escherichia coli 0111. PubMed: Supplementation of milk with iron bound to lactoferrin using weanling mice: L. Effects on hematology and tissue iron. PubMed: The effect of trypsin and chymotrypsin on the in vitro antimicrobial and iron-binding properties of lactoferrin in human milk and bovine colostrum. Unusual resistance of human apolactoferrin to proteolytic digestion. PubMed: Evidence for role of hydroxyl radical in complement and neutrophil-dependent tissue injury. PubMed: Suppression of mouse myelopoiesis by administration of human lactoferrin in vivo and the comparative action of human transferrin. PubMed: Spectroscopic studies on copper (II) complexes of human lactoferrin. PubMed: Transferrin receptors of human fibroblasts. Analysis of receptor properties and regulation. PubMed: Bactericidal activity of human lactoferrin: differentiation from the stasis of iron deprivation. PubMed: Studies on human lactoferrin by electron paramagnetic resonance, fluorescence, and resonance Raman spectroscopy. PubMed: Lactoferrin turnover in man. PubMed: A bactericidal effect for human lactoferrin. PubMed: In vitro growth inhibition of mastitis-causing coliform bacteria by bovine apo-lactoferrin and reversal of inhibition by citrate and high concentrations of apo-lactoferin. PubMed: The effect of trypsin on bovine transferrin and lactoferrin. PubMed: The involvement of lactoferrin in the hyposideremia of acute inflammation. PubMed: Association of lactoferrin with other proteins, as demonstrated by changes in electrophoretic mobility.