alpha-arbutin

4-hydroxyphenyl a-D-glucopyranoside

CAS: 84380-01-8 C12 H16 O7 MW: 272.25392000

Identification

Namealpha-arbutin
IUPAC(2R,3S,4S,5R,6R)-2-(hydroxymethyl)-6-(4-hydroxyphenoxy)oxane-3,4,5-triol
CAS Number84380-01-8
FDA UNII72VUP07IT5
Molecular FormulaC12 H16 O7
Molecular Weight272.25392000
MDL NumberMFCD09838262
Nikkaji NumberJ593.405B
Beilstein89675

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Soluble in water, 9.591e+005 mg/L @ 25 °C (est)

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesantioxidants

No sensory data available

Safety Information

Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryantioxidant, bleaching, skin conditioning
Recommendation for alpha-arbutin usage levels up tonot for fragrance use.
Recommendation for alpha-arbutin flavor usage levels up tonot for flavor use.

BOC Sciences

Best of Chemicals Supplier

Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecul...

View All Website 1-631-485-4226 account@bocsci.com

ECSA Chemicals

Human Chemistry

ECSA Chemicals has been active since 1913 in the trading and international commerce of raw materials. With an organisation divided into industrial segments managed by specialists, it has become one of...

View All Website +41 91 695 88 00 marketing@ecsa.ch

Glentham Life Sciences Ltd

The Chemical, Biochemical & Research Essentials Supplier

Glentham Life Sciences is a supplier of fine chemicals and raw materials with warehousing, laboratories and packaging facilities in the UK.

View All Website +44 (0) 1225 667798 info@glentham.com

Jiangyin Healthway International Trade Co., Ltd

Independent Ingredients Supplier

We provide custom synthesis and contract manufacturing from milligrams to metric tonnes.

View All Website 86-510-86023169 info@healthwaychem.com

Potential Uses

None Found

Natural Occurrence

not found in nature

Synonyms

a-D- glucopyranoside, 4-hydroxyphenyl (2R,3S,4S,5R,6R)-2-( hydroxymethyl)-6-(4-hydroxyphenoxy)oxane-3,4,5-triol 4- hydroxyphenyl a-D-glucopyranoside 4- hydroxyphenyl-alpha-D-glucopyranoside PubMed: Assessment of a Novel Anti-Aging Hand Cream. PubMed: Opinion of the Scientific Committee on Consumer safety (SCCS) - Opinion on the safety of the use of α-arbutin in cosmetic products. PubMed: Comparative studies on the chemical and enzymatic stability of alpha- and beta-arbutin. PubMed: Quantitative Determination of α-Arbutin, β-Arbutin, Kojic Acid, Nicotinamide, Hydroquinone, Resorcinol, 4-Methoxyphenol, 4-Ethoxyphenol, and Ascorbic Acid from Skin Whitening Products by HPLC-UV. PubMed: Dual effects of alpha-arbutin on monophenolase and diphenolase activities of mushroom tyrosinase. PubMed: Penetration depth, concentration and efficiency of transdermal α-arbutin delivery after ultrasound treatment with albumin-shelled microbubbles in mice. PubMed: Triterpenoids from Fragaria ananassa calyx and their inhibitory effects on melanogenesis in B16-F10 mouse melanoma cells. PubMed: Feeding strategies for the enhanced production of α-arbutin in the fed-batch fermentation of Xanthomonas maltophilia BT-112. PubMed: [Properties of sucrose phosphorylase from recombinant Escherichia coli and enzymatic synthesis of alpha-arbutin]. PubMed: Isolation of α-arbutin from Xanthomonas CGMCC 1243 fermentation broth by macroporous resin adsorption chromatography. PubMed: Screening of high α-arbutin producing strains and production of α-arbutin by fermentation. PubMed: Biotechnological production of arbutins (α- and β-arbutins), skin-lightening agents, and their derivatives. PubMed: High-yield enzymatic bioconversion of hydroquinone to α-arbutin, a powerful skin lightening agent, by amylosucrase. PubMed: Sucrose isomerase and its mutants from Erwinia rhapontici can synthesise α-arbutin. PubMed: Experimental study on cross-reactivity of alpha-arbutin toward p-phenylenediamine and hydroquinone in guinea pigs. PubMed: Treatment of refractory melasma with the MedLite C6 Q-switched Nd:YAG laser and alpha arbutin: a prospective study. PubMed: [Determination of alpha-arbutin, beta-arbutin and niacinamide in cosmetics by high performance liquid chromatography]. PubMed: Treatment of refractory dermal melasma with the MedLite C6 Q-switched Nd:YAG laser: two case reports. PubMed: High cell density cultivation of Escherichia coli with surface anchored transglucosidase for use as whole-cell biocatalyst for alpha-arbutin synthesis. PubMed: Modulating effects of a novel skin-lightening agent, alpha-lipoic acid derivative, on melanin production by the formation of DOPA conjugate products. PubMed: Surface display of transglucosidase on Escherichia coli by using the ice nucleation protein of Xanthomonas campestris and its application in glucosylation of hydroquinone. PubMed: A new synthesis of alpha-arbutin via Lewis acid catalyzed selective glycosylation of tetra-O-benzyl-alpha-D-glucopyranosyl trichloroacetimidate with hydroquinone. PubMed: Syntheses of alpha-arbutin-alpha-glycosides and their inhibitory effects on human tyrosinase. PubMed: Enzymatic synthesis of alpha-arbutin by alpha-anomer-selective glucosylation of hydroquinone using lyophilized cells of Xanthomonas campestris WU-9701. PubMed: Inhibitory effects of alpha-arbutin on melanin synthesis in cultured human melanoma cells and a three-dimensional human skin model. PubMed: Syntheses of arbutin-alpha-glycosides and a comparison of their inhibitory effects with those of alpha-arbutin and arbutin on human tyrosinase. PubMed: Effects of alpha- and beta-arbutin on activity of tyrosinases from mushroom and mouse melanoma.