Identification

Namethaumatin
CAS Number53850-34-3
FDA UNIIKNC9Q0EE6G
Molecular Formulaunspecified
MDL NumberMFCD00132420

Regulatory

FDA/DG SANTE Petitions, Reviews, NoticesGRN 738
JECFA Food AdditiveThaumatin
GSFA CodexThaumatin (957)
DG SANTE Food Additivesthaumatin
FEMA Number3732
FDANo longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm (SATF)53850-34-3 ; THAUMATIN

Physical Properties

Appearance cream crystalline powder (est)
Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Soluble in water
Insoluble in acetone

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesperfuming agents

Organoleptic Properties

Odor Strength none
Odor Description at 100.00 %.
Taste Description very sweet

Safety Information

Preferred SDSView
Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorysweeteners, flavor enhancers
Recommendation for thaumatin usage levels up tonot for fragrance use.
baked goods-
beverages(nonalcoholic)-
beverages(alcoholic)-
breakfast cereal-
cheese-
chewing gum-
condiments / relishes-
confectionery froastings-
egg products-
fats / oils-
fish products-
frozen dairy-
fruit ices-
gelatins / puddings-
granulated sugar-
gravies-
hard candy-
imitation dairy-
instant coffee / tea-
jams / jellies-
meat products-
milk products-
nut products-
other grains-
poultry-
processed fruits-
processed vegetables-
reconstituted vegetables-
seasonings / flavors-
snack foods-
soft candy-
soups-
sugar substitutes-
sweet sauces-

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Potential Uses

naturex carries FL sweet

Natural Occurrence

thaumatococcus daniellii fruit

Synonyms

proteins thaumatins talin natural thaumatin thaumatin 10% on gum arabic thaumatin 10% on maltodextrin thaumatin 5% in aqueous glycerol thaumatin 5% in aqueous propylene glycol thaumatins proteins PubMed: Natural sweeteners in a human diet. PubMed: Transcriptomic changes during maize roots development responsive to Cadmium (Cd) pollution using comparative RNAseq-based approach. PubMed: Cannabis Allergy: What do We Know Anno 2015. PubMed: Proteomic Analysis of Sauvignon Blanc Grape Skin, Pulp and Seed and Relative Quantification of Pathogenesis-Related Proteins. PubMed: Wine protein haze: mechanisms of formation and advances in prevention. PubMed: Study of combined effect of proteins and bentonite fining on the wine aroma loss. PubMed: In silico and experimental evaluation of DNA-based detection methods for the ability to discriminate almond from other Prunus spp. PubMed: Absolute quantification of protein NP24 in tomato fruit by liquid chromatography/tandem mass spectrometry using stable isotope-labelled tryptic peptide standard. PubMed: Quantitative RT-PCR analysis of differentially expressed genes in Quercus suber in response to Phytophthora cinnamomi infection. PubMed: Grease matrix as a versatile carrier of proteins for serial crystallography. PubMed: Atomic structure of recombinant thaumatin II reveals flexible conformations in two residues critical for sweetness and three consecutive glycine residues. PubMed: A thaumatin-like protein, Rj4, controls nodule symbiotic specificity in soybean. PubMed: The effect of kiwifruit (Actinidia deliciosa) cysteine protease actinidin on the occludin tight junction network in T84 intestinal epithelial cells. PubMed: The allergenic structure of the thaumatin-like protein Ole e 13 is degraded by processing of raw olive fruits. PubMed: The role of N-glycosylation in kiwi allergy. PubMed: Protocol for simultaneous isolation of three important banana allergens. PubMed: Immunotherapy and tolerance—cutting edge. PubMed: Identification and characterization of a basic thaumatin-like protein (TLP 2) as an allergen in sapodilla plum (Manilkara zapota). PubMed: Biochemical characterization of fruit-specific pathogenesis-related antifungal protein from basrai banana. PubMed: In silico analyses of structural and allergenicity features of sapodilla (Manilkara zapota) acidic thaumatin-like protein in comparison with allergenic plant TLPs. PubMed: Characterization and gene cloning of an acidic thaumatin-like protein (TLP 1), an allergen from sapodilla fruit (Manilkara zapota). PubMed: Identification of thaumatin-like protein and aspartyl protease as new major allergens in lettuce (Lactuca sativa). PubMed: Kiwifruit proteins and enzymes: actinidin and other significant proteins. PubMed: Five amino acid residues in cysteine-rich domain of human T1R3 were involved in the response for sweet-tasting protein, thaumatin. PubMed: Diversity and relative levels of actinidin, kiwellin, and thaumatin-like allergens in 15 varieties of kiwifruit (Actinidia). PubMed: Biomarker genes highlight intraspecific and interspecific variations in the responses of Pinus taeda L. and Pinus radiata D. Don to Sirex noctilio F. acid gland secretions. PubMed: Identification of avocado (Persea americana) pulp proteins by nano-LC-MS/MS via combinatorial peptide ligand libraries. PubMed: Roles of proteins, polysaccharides, and phenolics in haze formation in white wine via reconstitution experiments. PubMed: The involvement of thaumatin-like proteins in plant food cross-reactivity: a multicenter study using a specific protein microarray. PubMed: Comparative analyses of three legume species reveals conserved and unique root extracellular proteins. PubMed: Lipid transfer proteins and thaumatins as relevant allergens in melon peel allergy. PubMed: [Molecular aspects of allergy to plant products. Part III. Panallergens and breeding of hypoallergenic cultivars]. PubMed: Atomic structure of the sweet-tasting protein thaumatin I at pH 8.0 reveals the large disulfide-rich region in domain II to be sensitive to a pH change. PubMed: Plant bioreactors - the taste of sweet success. PubMed: Stability of white wine proteins: combined effect of pH, ionic strength, and temperature on their aggregation. PubMed: Identification of novel sweet protein for nutritional applications. PubMed: Identification of olive (Olea europaea) pulp proteins by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and nano-liquid chromatography tandem mass spectrometry. PubMed: Crystal structure of the sweet-tasting protein thaumatin II at 1.27Å. PubMed: High-resolution structure of the recombinant sweet-tasting protein thaumatin I. PubMed: A new approach to the isolation and characterization of wheat flour allergens. PubMed: Effects of ionic strength and sulfate upon thermal aggregation of grape chitinases and thaumatin-like proteins in a model system. PubMed: Sensitization profiles to purified plant food allergens among pediatric patients with allergy to banana. PubMed: Roles of grape thaumatin-like protein and chitinase in white wine haze formation. PubMed: Immunoglobulin-E reactivity to wine glycoproteins in heavy drinkers. PubMed: Noah's nectar: the proteome content of a glass of red wine. PubMed: Characterization of peach thaumatin-like proteins and their identification as major peach allergens. PubMed: Pseudomyrmex ants and Acacia host plants join efforts to protect their mutualism from microbial threats. PubMed: Variability in xylanase and xylanase inhibition activities in different cereals in the HEALTHGRAIN diversity screen and contribution of environment and genotype to this variability in common wheat. PubMed: Thaumatin-like protein and baker's respiratory allergy. PubMed: Thermal stability of thaumatin-like protein, chitinase, and invertase isolated from Sauvignon blanc and Semillon juice and their role in haze formation in wine. PubMed: Two-step purification of pathogenesis-related proteins from grape juice and crystallization of thaumatin-like proteins. PubMed: Aroma release from wines under dynamic conditions. PubMed: Interactions of the sweet-tasting proteins thaumatin and lysozyme with the human sweet-taste receptor. PubMed: QTL-specific microarray gene expression analysis of wheat resistance to Fusarium head blight in Sumai-3 and two susceptible NILs. PubMed: Aroma evaluation of transgenic, thaumatin II-producing cucumber fruits. PubMed: Grape and wine proteins: their fractionation by hydrophobic interaction chromatography and identification by chromatographic and proteomic analysis. PubMed: The three classes of wheat xylanase-inhibiting proteins accumulate in an analogous way during wheat ear development and germination. PubMed: A quantitative portrait of three xylanase inhibiting protein families in different wheat cultivars using 2D-DIGE and multivariate statistical tools. PubMed: Oat (Avena sativa) seed extract as an antifungal food preservative through the catalytic activity of a highly abundant class I chitinase. PubMed: Immunoblot quantification of three classes of proteinaceous xylanase inhibitors in different wheat ( Triticum aestivum ) cultivars and milling fractions. PubMed: Biochemical and structural characterization of TLXI, the Triticum aestivum L. thaumatin-like xylanase inhibitor. PubMed: Characterization of Bet v 1-related allergens from kiwifruit relevant for patients with combined kiwifruit and birch pollen allergy. PubMed: Purification and characterisation of relevant natural and recombinant apple allergens. PubMed: Effects of gastrointestinal digestion and heating on the allergenicity of the kiwi allergens Act d 1, actinidin, and Act d 2, a thaumatin-like protein. PubMed: Mal d 2, the thaumatin-like allergen from apple, is highly resistant to gastrointestinal digestion and thermal processing. PubMed: Critical molecular regions for elicitation of the sweetness of the sweet-tasting protein, thaumatin I. PubMed: Quantification of the thaumatin-like kiwi allergen by a monoclonal antibody-based ELISA. PubMed: Airway disease and thaumatin-like protein in an olive-oil mill worker. PubMed: Variability of polymorphic families of three types of xylanase inhibitors in the wheat grain proteome. PubMed: Immunoglobulin E recognition patterns to purified Kiwifruit (Actinidinia deliciosa) allergens in patients sensitized to Kiwi with different clinical symptoms. PubMed: Xylanase inhibitors bind to nonstarch polysaccharides. PubMed: Effects of pre- and pro-sequence of thaumatin on the secretion by Pichia pastoris. PubMed: Cloning of the thaumatin I cDNA and characterization of recombinant thaumatin I secreted by Pichia pastoris. PubMed: Purification, cloning, and identification of two thaumatin-like protein isoforms in jelly fig (Ficus awkeotsang) Achenes. PubMed: Sulfate--a candidate for the missing essential factor that is required for the formation of protein haze in white wine. PubMed: TLXI, a novel type of xylanase inhibitor from wheat (Triticum aestivum) belonging to the thaumatin family. PubMed: Severe immediate allergic reactions to grapes: part of a lipid transfer protein-associated clinical syndrome. PubMed: Developments in biotechnological production of sweet proteins. PubMed: Mass spectrometry in the analysis of grape and wine proteins. PubMed: Crystallization and preliminary structure determination of the plant food allergen Pru av 2. PubMed: Natural and recombinant molecules of the cherry allergen Pru av 2 show diverse structural and B cell characteristics but similar T cell reactivity. PubMed: Pollen allergens are restricted to few protein families and show distinct patterns of species distribution. PubMed: Thirteen-week feeding study of thaumatin (a natural proteinaceous sweetener), sterilized by electron beam irradiation, in Sprague-Dawley rats. PubMed: IgE sensitization profiles toward green and gold kiwifruits differ among patients allergic to kiwifruit from 3 European countries. PubMed: In vitro and in vivo characterization of hazelnut skin prick test extracts. PubMed: Thaumatin-like proteins -- a new family of pollen and fruit allergens. PubMed: Cloning, expression and characterization of recombinant sweet-protein thaumatin II using the methylotrophic yeast Pichia pastoris. PubMed: Behavioral study in the gray mouse lemur (Microcebus murinus) using compounds considered sweet by humans. PubMed: [Allergies associated with both food and pollen]. PubMed: How accurate and safe is the diagnosis of hazelnut allergy by means of commercial skin prick test reagents? PubMed: Environmental conditions during vegetative growth determine the major proteins that accumulate in mature grapes. PubMed: Plant-based heterologous expression of Mal d 2, a thaumatin-like protein and allergen of apple (Malus domestica), and its characterization as an antifungal protein. PubMed: Identification of grape and wine allergens as an endochitinase 4, a lipid-transfer protein, and a thaumatin. PubMed: Pathogenesis-related (PR)-proteins identified as allergens. PubMed: Isolation and biochemical characterization of a thaumatin-like kiwi allergen. PubMed: Isolation and molecular analysis of six taproot expressed genes from sugar beet. PubMed: Sweetener preference of C57BL/6ByJ and 129P3/J mice. PubMed: Use of electrospray mass spectrometry for mass determination of grape (Vitis vinifera) juice pathogenesis-related proteins: a potential tool for varietal differentiation. PubMed: Sweetness of sweet protein thaumatin is more thermoresistant under acid conditions than under neutral or alkaline conditions. PubMed: Structure-sweetness relationship in thaumatin: importance of lysine residues. PubMed: Molecular and biochemical classification of plant-derived food allergens. PubMed: Thaumatin-like proteins and chitinases, the haze-forming proteins of wine, accumulate during ripening of grape (Vitis vinifera) berries and drought stress does not affect the final levels per berry at maturity. PubMed: Thaumatin: a natural flavour ingredient. PubMed: Heat-induced formation of intermolecular disulfide linkages between thaumatin molecules that do not contain cysteine residues. PubMed: Issues and advances in the use of transgenic organisms for the production of thaumatin, the intensely sweet protein from Thaumatococcus danielli. PubMed: Characteristics of antisweet substances, sweet proteins, and sweetness-inducing proteins. PubMed: Sweet taste receptor mechanisms. PubMed: Safety evaluation of thaumatin (Talin protein). PubMed: Sugar substitutes: reasons and indications for their use.