calcium cyclamate
sulfamic acid, N-cyclohexyl-, calcium salt (2:1)
Identification
| Name | calcium cyclamate |
| IUPAC | calcium;N-cyclohexylsulfamate |
| CAS Number | 139-06-0 |
| EINECS | 205-349-4 |
| FDA UNII | X12LMJ1WYL |
| Molecular Formula | C12 H24 Ca N2 O6 S2 |
| Molecular Weight | 396.54048000 |
| MDL Number | MFCD03939072 |
| Nikkaji Number | J55.433B |
Regulatory
| JECFA Food Additive | Calcium Cyclamate |
| GSFA Codex | Calcium cyclamate (952(ii)) |
| DG SANTE Food Additives | calcium cyclamate |
| FDA Mainterm (SATF) | 5897-16-5 ; CALCIUM CYCLAMATE--PROHIBITED |
| FDA Regulation | FDA PART 189 -- SUBSTANCES PROHIBITED FROM USE IN HUMAN FOOD |
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Soluble in | water, 11.38 mg/L @ 25 °C (est) |
Cosmetic Information
| CosIng | cosmetic data |
| Cosmetic Uses | fragrance |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | intravenous-mouse LDLo 3500 ug/kg |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | masking agents |
| Recommendation for calcium cyclamate usage levels up to | not for fragrance use. |
| Recommendation for calcium cyclamate flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
calcium bis (cyclohexylsulfamate)
calcium bis(cyclohexylsulfamate)
calcium cyclohexane sulphamate
calcium cyclohexylsulphamate
calcium;N-cyclohexylsulfamate
sulfamic acid, cyclohexyl-, calcium salt (2:1)
sulfamic acid, N-cyclohexyl-, calcium salt (2:1)
PubMed:
The metabolism of cyclamate to cyclohexylamine in humans during long-term administration.
PubMed:
Effects of a saccharin and cyclamate mixture on rat embryos.
PubMed:
Taste qualities of solutions preferred by hamsters.
PubMed:
Gustatory neural coding in the monkey cortex: the quality of sweetness.
PubMed:
The metabolism of cyclamate to cyclohexylamine and its cardiovascular consequences in human volunteers.
PubMed:
Assessment of the genotoxicity of calcium cyclamate and cyclohexylamine.
PubMed:
Myocardial effects of calcium cyclamate in the BIO F1D Alexander Syrian golden hamster.
PubMed:
No evidence found for induction of dominant lethal mutations and heritable translocations in male mice by calcium cyclamate.
PubMed:
Caffeine intensifies taste of certain sweeteners: role of adenosine receptor.
PubMed:
Sensory evaluation of soft drinks with various sweeteners.
PubMed:
Cytogenetic effects of cyclamates.
PubMed:
The mutagenic activity of 61 agents as determined by the micronucleus, Salmonella, and sperm abnormality assays.
PubMed:
Chemical induction of sperm abnormalities in mice.
PubMed:
A toxicity method with calcium cyclamate for chronic carcinogenesis experiments.
PubMed:
Cytogenetic studies on calcium cyclamate in Meriones unguiculatus (gerbil) in vivo.
PubMed:
In vitro cytogenetic investigation of calcium cyclamate, cyclohexylamine and triflupromazine.
PubMed:
Aspartylphenylalanine methyl ester: a low-calorie sweetener.
PubMed:
Effect of maternal calcium cyclamate intake on cellular development in the young rat.
PubMed:
Calcium cyclamate and renal tubular acidosis.
PubMed:
Photosensitive dermatitis and renal tubular acidosis after ingestion of calcium cyclamate.
PubMed:
Sugar substitute, sodium and calcium cyclamate.
PubMed:
Myocardial lesions: a reassessment of the toxicology of calcium cyclamate.
PubMed:
Cytogenetic effects of cyclamates on human cells in vitro.
PubMed:
[Effects on rat's intestinal mucosa of prolonged calcium cyclamate administration].
PubMed:
Feeding and reproduction of rats fed calcium cyclamate.