2-aminopyrazine
pyrazin-2-ylamine
Identification
| Name | 2-aminopyrazine |
| IUPAC | pyrazin-2-amine |
| CAS Number | 5049-61-6 |
| EINECS | 225-748-7 |
| FDA UNII | Search |
| Molecular Formula | C4 H5 N3 |
| Molecular Weight | 95.10485000 |
| MDL Number | MFCD00006137 |
| Nikkaji Number | J80.944F |
| Beilstein | 107025 |
| XlogP3 | -0.10 (est) |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Boiling Point | 250.00 to 251.00 °C. @ 760.00 mm Hg (est) |
| Vapor Pressure | 0.246000 mmHg @ 20.00 °C. (est) |
| Flash Point | 264.00 °F. TCC ( 129.10 °C. ) (est) |
| logP (o/w) | -0.070 |
| Soluble in | alcohol |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | pharmaceuticals / chemical synthisis |
| Recommendation for 2-aminopyrazine usage levels up to | not for fragrance use. |
| Recommendation for 2-aminopyrazine flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
2-
amino pyrazine
aminopyrazine
pyrazin-2-amine
pyrazin-2-ylamine
2-
pyrazinamine
pyrazine-2-ylamine
pyrazine, 2-amino-
PubMed:
Identification of AKN-032, a novel 2-aminopyrazine tyrosine kinase inhibitor, with significant preclinical activity in acute myeloid leukemia.
PubMed:
Poly[bis(mu2-2-aminopyrazine-kappa2N1:N4)(mu2-nitrato-kappa2O:O)(nitrato-kappa2O,O')disilver(I)]: an achiral two-dimensional coordination polymer forming chiral crystals.
PubMed:
Synthesis of some new anils: part 1. Reaction of 2-hydroxy-benzaldehyde and 2-hydroxynaphthaldehyde with 2-aminopyridene and 2-aminopyrazine.
PubMed:
Mercapturic acid formation from 2-aminopyrazine in rats.
PubMed:
Poly[mu-2-aminopyrazine-kappa2N1:N4-mu-cyanido-copper(I)]: a three-dimensional network from laboratory powder diffraction data.
PubMed:
[Synthesis of the furan derivatives. XLVII. Synthesis of 5,6-bis(5-nitro-2-furyl)-2-aminopyrazine and its related compound].
PubMed:
Multiple hydrogen bonding in excited states of aminopyrazine in methanol solution: time-dependent density functional theory study.
PubMed:
Structure-activity-relationship studies around the 2-amino group and pyridine core of antimalarial 3,5-diarylaminopyridines lead to a novel series of pyrazine analogues with oral in vivo activity.
PubMed:
In vitro and in vivo activities of 2-aminopyrazines and 2-aminopyridines in experimental models of human African trypanosomiasis.
PubMed:
Spin canting and metamagnetism in 2D and 3D cobalt(II) coordination networks with alternating double end-on and double end-to-end azido bridges.
PubMed:
Water-induced reversible structural phase transformation with chromotropism in metal supramolecular frameworks containing aminopyrazine and sulfate anions.
PubMed:
Chemistry around imidazopyrazine and ibuprofen: discovery of novel fatty acid amide hydrolase (FAAH) inhibitors.
PubMed:
New discrete and polymeric supramolecular architectures derived from dinuclear (bis-beta-diketonato)copper(II) metallocycles.
PubMed:
Synthesis and spectroscopic characterization of copper(II) tetraazaiminooxime macrocyclic complexes--a tetragonal distortion analysis.
PubMed:
Antibacterial cobalt(II) and zinc(II) complexes of pyrazine-derived NNO and NNN donor Schiff-bases.
PubMed:
Catechol derivatives of aminopyrazine and cell protection against UVB-induced mortality.
PubMed:
Copper(I) cyanide networks: synthesis, luminescence behavior and thermal analysis. Part 1. Diimine ligands.
PubMed:
Chemistry of stable iminopropadienones, RN=C=C=C=O.
PubMed:
[Studies on pyrazine derivatives. XXVI. Synthesis and tuberculostatic activity of N-pyrazinylthiourea].