2-aminopyrazine

pyrazin-2-ylamine

CAS: 5049-61-6 C4 H5 N3 MW: 95.10485000

Identification

Name2-aminopyrazine
IUPACpyrazin-2-amine
CAS Number5049-61-6
EINECS225-748-7
FDA UNIISearch
Molecular FormulaC4 H5 N3
Molecular Weight95.10485000
MDL NumberMFCD00006137
Nikkaji NumberJ80.944F
Beilstein107025
XlogP3-0.10 (est)

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Boiling Point 250.00 to 251.00 °C. @ 760.00 mm Hg (est)
Vapor Pressure 0.246000 mmHg @ 20.00 °C. (est)
Flash Point 264.00 °F. TCC ( 129.10 °C. ) (est)
logP (o/w) -0.070
Soluble in alcohol

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorypharmaceuticals / chemical synthisis
Recommendation for 2-aminopyrazine usage levels up tonot for fragrance use.
Recommendation for 2-aminopyrazine flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

not found in nature

Synonyms

2- amino pyrazine aminopyrazine pyrazin-2-amine pyrazin-2-ylamine 2- pyrazinamine pyrazine-2-ylamine pyrazine, 2-amino- PubMed: Identification of AKN-032, a novel 2-aminopyrazine tyrosine kinase inhibitor, with significant preclinical activity in acute myeloid leukemia. PubMed: Poly[bis(mu2-2-aminopyrazine-kappa2N1:N4)(mu2-nitrato-kappa2O:O)(nitrato-kappa2O,O')disilver(I)]: an achiral two-dimensional coordination polymer forming chiral crystals. PubMed: Synthesis of some new anils: part 1. Reaction of 2-hydroxy-benzaldehyde and 2-hydroxynaphthaldehyde with 2-aminopyridene and 2-aminopyrazine. PubMed: Mercapturic acid formation from 2-aminopyrazine in rats. PubMed: Poly[mu-2-aminopyrazine-kappa2N1:N4-mu-cyanido-copper(I)]: a three-dimensional network from laboratory powder diffraction data. PubMed: [Synthesis of the furan derivatives. XLVII. Synthesis of 5,6-bis(5-nitro-2-furyl)-2-aminopyrazine and its related compound]. PubMed: Multiple hydrogen bonding in excited states of aminopyrazine in methanol solution: time-dependent density functional theory study. PubMed: Structure-activity-relationship studies around the 2-amino group and pyridine core of antimalarial 3,5-diarylaminopyridines lead to a novel series of pyrazine analogues with oral in vivo activity. PubMed: In vitro and in vivo activities of 2-aminopyrazines and 2-aminopyridines in experimental models of human African trypanosomiasis. PubMed: Spin canting and metamagnetism in 2D and 3D cobalt(II) coordination networks with alternating double end-on and double end-to-end azido bridges. PubMed: Water-induced reversible structural phase transformation with chromotropism in metal supramolecular frameworks containing aminopyrazine and sulfate anions. PubMed: Chemistry around imidazopyrazine and ibuprofen: discovery of novel fatty acid amide hydrolase (FAAH) inhibitors. PubMed: New discrete and polymeric supramolecular architectures derived from dinuclear (bis-beta-diketonato)copper(II) metallocycles. PubMed: Synthesis and spectroscopic characterization of copper(II) tetraazaiminooxime macrocyclic complexes--a tetragonal distortion analysis. PubMed: Antibacterial cobalt(II) and zinc(II) complexes of pyrazine-derived NNO and NNN donor Schiff-bases. PubMed: Catechol derivatives of aminopyrazine and cell protection against UVB-induced mortality. PubMed: Copper(I) cyanide networks: synthesis, luminescence behavior and thermal analysis. Part 1. Diimine ligands. PubMed: Chemistry of stable iminopropadienones, RN=C=C=C=O. PubMed: [Studies on pyrazine derivatives. XXVI. Synthesis and tuberculostatic activity of N-pyrazinylthiourea].