2-tert-butyl-para-cresol

phenol, (1,1-dimethylethyl)-4-methyl-

CAS: 2409-55-4 C11 H16 O MW: 164.24772000 leathery

Identification

Name2-tert-butyl-para-cresol
IUPAC2-tert-butyl-4-methylphenol
CAS Number2409-55-4
EINECS219-314-6
FDA UNIIY9VVU7G7J4
Molecular FormulaC11 H16 O
Molecular Weight164.24772000
MDL NumberMFCD00002381
Nikkaji NumberJ48.502K
Beilstein1817645
XlogP33.60 (est)

Regulatory

Physical Properties

Appearance clear tan solid (est)
Assay 98.00 to 100.00
Food Chemicals Codex Listed No
Melting Point 51.00 to 52.00 °C. @ 760.00 mm Hg
Boiling Point 237.00 °C. @ 760.00 mm Hg
Vapor Pressure 0.030000 mmHg @ 25.00 °C. (est)
Flash Point 212.00 °F. TCC ( 100.00 °C. )
logP (o/w) 3.877 (est)
Soluble in alcohol
Insoluble in water

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesperfuming agents

Organoleptic Properties

Odor Strength high ,
Substantivity 400 hour(s) at 10.00 % in dipropylene glycol
Odor Description at 100.00 %.

Safety Information

Preferred SDSView
European informationMost important hazard(s):
Oral/Parenteral Toxicityoral-mouse LD50 700 mg/kg
Dermal Toxicityskin-rabbit LDLo 2200 mg/kg
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements', 'U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#03020', 'BEHAVIORAL: COMA\nBEHAVIORAL: TREMOR\nPERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE', 'PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE\nBEHAVIORAL: TREMOR\nBEHAVIORAL: COMA']

Safety in Use

Categorycosmetic and fragrance agents
RIFM Fragrance Material Safety AssessmentSearch
Recommendation for 2-tert-butyl-para-cresol usage levels up to0.0200 % in the fragrance concentrate.
Recommendation for 2-tert-butyl-para-cresol flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

not found in nature

Synonyms

2-tert- butyl-4-methoxyphenol 2-tert- butyl-4-methyl phenol 2-tert- butyl-4-methyl-1-phenol 2-tert- butyl-4-methyl-phenol 2-t- butyl-4-methylphenol 2-tert- butyl-4-methylphenol 2-t- butyl-p-cresol 2-tert- butyl-p-cresol o-tert- butyl-p-cresol tert- butyl-p-cresol o-tert- butyl-para-cresol ortho-tert- butyl-para-cresol 2-(tert- butyl)-4-methyl phenol 2-(tert- butyl)-4-methylphenol 4- cresol, 2-t-butyl- p- cresol, 2-tert-butyl- 2-(1,1- dimethyl ethyl)-4-methyl phenol 2-(1,1- dimethylethyl)-4-methyl-phenol 2-(1,1- dimethylethyl)-4-methylphenol 1- hydroxy-2-tert-butyl-4-methyl benzene 1- hydroxy-2-tert-butyl-4-methylbenzene 4- methyl-2-(1,1-dimethyl ethyl) phenol 4- methyl-2-(1,1-dimethylethyl)phenol 4- methyl-2-(2-methyl-2-propanyl)phenol 4- methyl-2-t-butylphenol 4- methyl-2-tert-butyl phenol 4- methyl-2-tert-butylphenol 4- methyl-6-t-butylphenol 4- methyl-6-tert-butyl phenol 4- methyl-6-tert-butylphenol phenol, (1,1-dimethylethyl)-4-methyl- phenol, 2- (1,1-dimethylethyl)-4-methyl- phenol, 2-(1,1-dimethylethyl)-4-methyl- PubMed: Pharmacological actions of thymol and an analogue at GABAB autoreceptors. PubMed: 2-Benzhydryl-6-tert-butyl-4-methyl-phenol. PubMed: Development and validation of HPLC methods for the determination of potential extractables from elastomeric stoppers in the presence of a complex surfactant vehicle used in the preparation of parenteral drug products. PubMed: Cytotoxicity and apoptosis induction by butylated hydroxyanisole (BHA) and butylated hydroxytoluene (BHT). PubMed: Interaction of 1-hydroxyethyl radical with antioxidant enzymes. PubMed: Capillary gas chromatographic assay of camphor and m-cresol in dermatological creams. PubMed: Effects of phenolic antioxidants in low dose combination on forestomach carcinogenesis in rats pretreated with N-methyl-N'-nitro-N-nitrosoguanidine. PubMed: Structure-activity relations in promotion of rat urinary bladder carcinogenesis by phenolic antioxidants. PubMed: Early proliferative responses of forestomach and glandular stomach of rats treated with five different phenolic antioxidants. PubMed: Free radical intermediates during peroxidase oxidation of 2-t-butyl-4-methoxyphenol, 2,6-di-t-butyl-4-methylphenol, and related phenol compounds. PubMed: Modification of N-methyl-N'-nitro-N-nitrosoguanidine-induced forestomach and glandular stomach carcinogenesis by phenolic antioxidants in rats. PubMed: Effects of subsequent antioxidant treatment on 7,12-dimethylbenz[a]anthracene-initiated carcinogenesis of the mammary gland, ear duct and forestomach in Sprague-Dawley rats. PubMed: Role of free radicals in the mode of action of anthralin. PubMed: Studies on antioxidants: their carcinogenic and modifying effects on chemical carcinogenesis. PubMed: Effect of monocyclic derivatives on DNA repair in human lymphocytes. PubMed: Comparison of the effects of 13 phenolic compounds in induction of proliferative lesions of the forestomach and increase in the labelling indices of the glandular stomach and urinary bladder epithelium of Syrian golden hamsters. PubMed: Pharmacologic and genetic studies on the modulatory effects of butylated hydroxytoluene on mouse lung adenoma formation.