2,6-diisopropyl phenol

2,6-bis(1-methylethyl)phenol

CAS: 2078-54-8 C12 H18 O MW: 178.27466000

Identification

Name2,6-diisopropyl phenol
IUPAC2,6-di(propan-2-yl)phenol
CAS Number2078-54-8
EINECS218-206-6
FDA UNIIYI7VU623SF
Molecular FormulaC12 H18 O
Molecular Weight178.27466000
MDL NumberMFCD00008885
Nikkaji NumberJ102.606B
Beilstein1866484
XlogP33.80 (est)

Regulatory

Physical Properties

Appearance colorless to pale yellow clear liquid (est)
Assay 96.00 to 100.00
Food Chemicals Codex Listed No
Specific Gravity 0.96200 @ 25.00 °C.
Refractive Index 1.51400 @ 20.00 °C.
Melting Point 18.00 °C. @ 760.00 mm Hg
Boiling Point 254.00 to 256.00 °C. @ 764.00 mm Hg
Vapor Pressure 0.010000 mmHg @ 25.00 °C. (est)
Vapor Density 5.6 ( Air = 1 )
Flash Point 235.00 °F. TCC ( 112.78 °C. )
logP (o/w) 3.790
Soluble in alcohol
Insoluble in water

Organoleptic Properties

Odor Strength low
Odor Description at 100.00 %.

Safety Information

Preferred SDSView
European informationMost important hazard(s):
Oral/Parenteral Toxicityintravenous-dog LD50 30 mg/kg
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements', 'BEHAVIORAL: GENERAL ANESTHETIC\nBEHAVIORAL: ANALGESIA\nBEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)']

Safety in Use

Categoryflavor and fragrance agents
RIFM Fragrance Material Safety AssessmentSearch

Berje Inc.

Where the world comes to its senses

Where the world comes to its senses - Berjé is a global distributor of Essential Oils and Aromatic Chemicals.

View All Website 973-748-8980 tlauzurica@berjeinc.com

BOC Sciences

Best of Chemicals Supplier

Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecul...

View All Website 1-631-485-4226 account@bocsci.com

Penta International Corporation

Chemistry innovation

At Penta, our products and services help businesses do business better.

View All Website (973) 740-2300 lisaa@pentamfg.com

Synerzine, Inc.

Innovation. Customization. Aroma Ingredients.

Synerzine is a leading supplier of flavor and fragrance ingredients.

View All Website (404) 524-6744 info@synerzine.com

Vigon International

Passion for Simplicity

Manufacturer and supplier of high quality flavor and fragrance ingredients.

View All Website 570-476-6300 sales@vigon.com

Potential Uses

None Found

Natural Occurrence

cheese parmesan cheese PMC cheese romano cheese PMC

Synonyms

ampofol aquafol aquavan 2,6- di-iso-propylphenol 2,6- di-isopropylphenol 2,6- di(propan-2-yl)phenol 2,6- diiso propyl phenol diisopropyl-2 6 phenol 2,6- diisopropyl-phenol diisopropylphenol 2,6- diisopropylphenol dipravan diprivan 10 2,6- dipropan-2-ylphenol disoprivan disoprofol fresofol ivofol 2,6-bis(1- methylethyl)benzolol 2,6-bis( methylethyl)phenol 2,6-bis(1- methylethyl)phenol phenol, 2,6-bis(1-methylethyl)- phenol, 2,6-diisopropyl- 2,6-bis( propan-2-yl)phenol propofol propofolum 2,6-bis(iso propyl) phenol 2,6-bis(iso propyl)-phenol 2,6-bis(iso propyl)phenol rapinovet recofol PubMed: Propofol infusion associated metabolic acidosis in patients undergoing neurosurgical anesthesia: a retrospective study. PubMed: Protective effect of acetyl-L-carnitine on propofol-induced toxicity in embryonic neural stem cells. PubMed: Propofol administration is safe in adult eosinophilic esophagitis patients sensitized to egg, soy, or peanut. PubMed: Drugs and the death penalty. PubMed: Effects of propofol on expression of hippocampal neuronal nitric oxide synthase and carboxy-terminal PDZ ligand of neuronal nitric oxide synthase in stressed rats undergoing electroconvulsive shock. PubMed: Entropy correlates with Richmond Agitation Sedation Scale in mechanically ventilated critically ill patients. PubMed: Simultaneous determination of 11 related impurities in propofol by gas chromatography/tandem mass spectrometry coupled with pulsed splitless injection technique. PubMed: Acitretin exhibits inhibitory effects towards UDP-glucuronosyltransferase (UGT)1A9-mediated 4-methylumbelliferone (4-MU) and propofol glucuronidation reaction. PubMed: Anaesthetic considerations for endoscopic retrograde cholangio-pancreatography procedures. PubMed: US Propofol Drug Shortages: A Review of the Problem and Stakeholder Analysis. PubMed: Claw amphiphiles with a dendrimer core: nanoparticle stability and drug encapsulation are directly proportional to the number of digits. PubMed: Assessment of oxidative stress and antioxidant property using electron spin resonance (ESR) spectroscopy. PubMed: Evaluation of sigmoidal maturation and allometric models: prediction of propofol clearance in neonates and infants. PubMed: Self-administration of propofol is mediated by dopamine D1 receptors in nucleus accumbens in rats. PubMed: Effects of propofol on the activation of hippocampal CaMKIIα in depressed rats receiving electroconvulsive therapy. PubMed: Propofol allergy: assessing for patient risks. PubMed: [Fospropofol: A new prodrug of propofol]. PubMed: Dexmedetomidine: a guide to its use for sedation in the US. PubMed: Identification of UDP-glucuronosyltransferase isoforms involved in hepatic and intestinal glucuronidation of phytochemical carvacrol. PubMed: When one drug affects 2 patients: a review of medication for the management of nonlabor-related pain, sedation, infection, and hypertension in the hospitalized pregnant patient. PubMed: Safe injection practices for administration of propofol. PubMed: Dependence potential of propofol: behavioral pharmacology in rodents. PubMed: Potential hypersensitivity due to the food or food additive content of medicinal products in Spain. PubMed: Pharmacokinetics of ketamine and propofol combination administered as ketofol via continuous infusion in cats. PubMed: Propofol sedation for ERCP procedures: a dilemna? Observations from an anesthesia perspective. PubMed: Differential involvement of GABAA and GABAB receptors in propofol self-administration in rats. PubMed: Drug shortage. PubMed: Procedural sedation practices in Australian Emergency Departments. PubMed: Anaesthesia of three young grey seals (Halichoerus grypus) for fracture repair. PubMed: Non-anaesthesiologists should not be allowed to administer propofol for procedural sedation: a Consensus Statement of 21 European National Societies of Anaesthesia. PubMed: Anesthesia in the patient with multiple drug allergies: are all allergies the same? PubMed: Allergic reactions to propofol in egg-allergic children. PubMed: Computer-assisted personalized sedation. PubMed: My patient is allergic to eggs, can i use propofol? A case report and review. PubMed: Why are there so many drug shortages? PubMed: Administration of propofol. PubMed: The reality of drug shortages--the case of the injectable agent propofol. PubMed: Identification of the human UDP-glucuronosyltransferases involved in the glucuronidation of combretastatin A-4. PubMed: [Unexpected vomiting during anesthetic induction in a patient with a history of anterosternal esophageal reconstruction]. PubMed: Off-label medication use in an academic hospital pediatric critical care unit. PubMed: Schedule of controlled substances; placement of fospropofol into schedule IV. Final rule. PubMed: Fospropofol: a new sedative-hypnotic agent for monitored anesthesia care. PubMed: Fospropofol disodium, a water-soluble prodrug of the intravenous anesthetic propofol (2,6-diisopropylphenol). PubMed: Effect of administration of propofol and xylazine hydrochloride on recovery of horses after four hours of anesthesia with desflurane. PubMed: Anesthesia or sedation for gastroenterologic endoscopies. PubMed: The effect of postoperative fasting on vomiting in children and their assessment of pain. PubMed: Self-limited febrile syndromes temporally associated with the use of propofol for sedation in gastrointestinal endoscopic procedures. PubMed: Fospropofol approved for monitored anesthesia care. PubMed: Delirium at the end of life. PubMed: Use of propofol in patients with food allergies. PubMed: Questions unanswered: propofol use in the pediatric intensive care unit. PubMed: [Elective colon resection in Germany. A survey of the perioperative anesthesiological management]. PubMed: Use of anesthetic agents in neonates and young children. PubMed: Delirium at the end of life. PubMed: Respiratory failure due to morbid obesity in a patient with Prader-Willi syndrome: an experience of long-term mechanical ventilation. PubMed: Reports of death with use of propofol (Diprivan) for nonprocedural (long-term) sedation and literature review. PubMed: Nurse-administered propofol sedation: a review of current evidence. PubMed: Electroconvulsive therapy (ECT) in a six-year-old girl suffering from major depressive disorder with catatonic features. PubMed: The propofol controversy. PubMed: The propofol debate continues. PubMed: Sedation and analgesia for gastrointestinal endoscopy during pregnancy. PubMed: The major role of clinicians in the discovery of off-label drug therapies. PubMed: Use of intravenous steroids at induction of anaesthesia for adult tonsillectomy to reduce post-operative nausea and vomiting and pain: a double-blind randomized controlled trial. PubMed: Propofol 6% as sedative in children under 2 years of age following major craniofacial surgery. PubMed: Droperidol and dolasetron alone or in combination for prevention of postoperative nausea and vomiting after vitrectomy. PubMed: Safety of sodium phosphate tablets in patients receiving propofol-based sedation for colonoscopy. PubMed: Efficacy and safety of endoscopic dilation of esophageal strictures in epidermolysis bullosa. PubMed: Glucuronidation as a mechanism of intrinsic drug resistance in human colon cancer: reversal of resistance by food additives. PubMed: The FDA warning against prolonged sedation with propofol in children remains warranted. PubMed: Pediatric drug labeling: improving the safety and efficacy of pediatric therapies. PubMed: [Caloric overload in critically ill patients treated with parenteral nutrition]. PubMed: Differential role of leptin receptors at the hypothalamic paraventricular nucleus in tonic regulation of food intake and cardiovascular functions. PubMed: Propofol syndrome in children. PubMed: Possible anaphylaxis after propofol in a child with food allergy. PubMed: Gastroenterologist-administered propofol versus meperidine and midazolam for advanced upper endoscopy: a prospective, randomized trial. PubMed: Propofol does not modify the hemodynamic status of children with intracardiac shunts undergoing cardiac catheterization. PubMed: Microchip vagal pacing reduces food intake and body mass. PubMed: The effect of propofol administered intravenously on appetite stimulation in dogs. PubMed: Enhanced intestinal motility influences absorption in anaesthetized rat. PubMed: Propofol improves recovery from paraquat acute toxicity in vitro and in vivo. PubMed: 'Diprivan': a change of formulation. PubMed: Comparison of the intravenous reinforcing effects of propofol and methohexital in baboons. PubMed: Propofol containing sulfite-potential for injury. PubMed: Antioxidant effects of propofol in human hepatic microsomes: concentration effects and clinical relevance. PubMed: "Preservatives" in propofol. PubMed: Effect of enteral versus parenteral feeding on hepatic blood flow and steady state propofol pharmacokinetics in ICU patients. PubMed: Muscimol-like discriminative stimulus effects of GABA agonists in rats. PubMed: [Ban of the use of metomidate (Hypnodil) in swine. Background, consequences and alternatives]. PubMed: Pharmacologic influence on nutrition support therapy: use of propofol in a patient receiving combined enteral and parenteral nutrition support. PubMed: The publication of commercially supported supplements statement. PubMed: How do anesthesiologists select patients when introducing a new drug into practice? PubMed: The initial clinical experience of 1819 physicians in maintaining anesthesia with propofol: characteristics associated with prolonged time to awakening. PubMed: Endogenous Candida endophthalmitis after intravenous anesthesia with propofol. PubMed: A method for quantitative analysis of flavor-tainting alkylphenols and aromatic thiols in fish.