5-hydroxymethyl furfural

hydroxymethylfurfuralaldehyde

CAS: 67-47-0 C6 H6 O3 MW: 126.11142000 fatty herbal

Identification

Name5-hydroxymethyl furfural
IUPAC5-(hydroxymethyl)furan-2-carbaldehyde
CAS Number67-47-0
EINECS200-654-9
FDA UNII70ETD81LF0
Molecular FormulaC6 H6 O3
Molecular Weight126.11142000
MDL NumberMFCD00003234
Nikkaji NumberJ4.850J
Beilstein0110889
CoE Number11112
XlogP3-0.60 (est)

Regulatory

DG SANTE Food Flavourings13.139 hydroxymethylfurfuralaldehyde

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Specific Gravity 1.24300 @ 25.00 °C.
Refractive Index 1.56200 @ 20.00 °C.
Melting Point 32.00 to 35.00 °C. @ 760.00 mm Hg
Boiling Point 114.00 to 116.00 °C. @ 1.00 mm Hg, 291.00 to 292.00 °C. @ 760.00 mm Hg
Vapor Pressure 0.001000 mmHg @ 25.00 °C. (est)
Flash Point 175.00 °F. TCC ( 79.44 °C. )
logP (o/w) -0.778 (est)
Soluble in alcohol
Insoluble in water

Organoleptic Properties

Odor Description at 0.10 % in dipropylene glycol.
Taste Description herbal hay tobacco

Safety Information

Preferred SDSView
European informationMost important hazard(s):
Oral/Parenteral Toxicityoral-rat LD50 3100 mg/kg
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryflavoring agents
Recommendation for 5-hydroxymethyl furfural usage levels up tonot for fragrance use.
Maximised Survey-derived Daily Intakes (MSDI-EU)0.39 (μg/capita/day)
Modified Theoretical Added Maximum Daily Intake (mTAMDI)1600 (μg/person/day)
Threshold of Concern540 (μg/person/day)
Structure ClassII
Dairy products, excluding products of category 02.0 (01.0)3.00000
Fats and oils, and fat emulsions (type water-in-oil) (02.0)2.00000
Edible ices, including sherbet and sorbet (03.0)3.00000
Processed fruit (04.1)2.00000
Processed vegetables (incl. mushrooms & fungi, roots & tubers, pulses and legumes), and nuts & seeds (04.2)-
Confectionery (05.0)4.00000
Chewing gum (05.3)-
Cereals and cereal products, incl. flours & starches from roots & tubers, pulses & legumes, excluding bakery (06.0)2.00000
Bakery wares (07.0)5.00000
Meat and meat products, including poultry and game (08.0)1.00000
Fish and fish products, including molluscs, crustaceans and echinoderms (MCE) (09.0)1.00000
Eggs and egg products (10.0)-
Sweeteners, including honey (11.0)-
Salts, spices, soups, sauces, salads, protein products, etc. (12.0)2.00000
Foodstuffs intended for particular nutritional uses (13.0)3.00000
Non-alcoholic ("soft") beverages, excl. dairy products (14.1)2.00000
Alcoholic beverages, incl. alcohol-free and low-alcoholic counterparts (14.2)4.00000
Ready-to-eat savouries (15.0)5.00000
Composite foods (e.g. casseroles, meat pies, mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0)2.00000

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Potential Uses

FL bread FL fat FR honey FR tobacco waxy

Natural Occurrence

almond roasted almond - 9 mg/kg apple juice PMC barley roasted barley beer - up to 8 mg/kg PMC brandy - up to 11.6 mg/kg PMC bread wheat bread - up to 19.1 mg/kg PMC caulifiower chicory cichorium intybus l. root extract @ 4.27% Data cloudberry fruit - 0.2 mg/kg coffee - up to 35 mg/kg PbMd PMC cognac PMC fruit canned PMC honey PMC milk - 0.03 mg/kg PMC onion onion roasted onion pineapple fruit popcorn PMC prune - up to 450 mg/kg PMC sherry - up to 680 mg/kg PMC strawberry jam vanilla whiskey - up to 10.1 mg/kg wine - up to 27.3 mg/kg wine port wine - up to 63 mg/kg wine white wine wood smoke

Synonyms

2- furaldehyde, 5-(hydroxymethyl)- 2- furaldehyde, 5-hydroxymethyl- 2- furancarboxaldehyde, 5-(hydroxymethyl)- 5- HMF 5- hydroxymethyl furaldehyde hydroxymethyl furfurole 5- hydroxymethyl-2-formyl furan 5- hydroxymethyl-2-formylfuran 5- hydroxymethyl-2-furaldehyde 5- hydroxymethyl-2-furancarboxaldehyde 5- hydroxymethyl-2-furfural 2- hydroxymethyl-5-furfural 5- hydroxymethyl-furfural 5-( hydroxymethyl) furfural 5-( hydroxymethyl)-2-furaldehyde 5-( hydroxymethyl)-2-furan carbonal 5-( hydroxymethyl)-2-furan carboxaldehyde 5-( hydroxymethyl)-2-furancarbonal 5-( hydroxymethyl)-2-furancarboxaldehyde 5-( hydroxymethyl)-2-furfural 5-( hydroxymethyl)-furfural 5-( hydroxymethyl)furan-2-carbaldehyde 5-( hydroxymethyl)furan-2-carboxaldehyde 5-( hydroxymethyl)furfural 5- hydroxymethylfuraldehyde 5- hydroxymethylfuran-2-aldehyde 5- hydroxymethylfurfural hydroxymethylfurfuralaldehyde hydroxymethylfurfurole 5-oxy methyl furfurole 5-oxy methylfurfurole PubMed: Non-targeted metabolomic reveals the effect of salt stress on global metabolite of halotolerant yeast Candida versatilis and principal component analysis. PubMed: Effect of roasting conditions on color and volatile profile including HMF level in sweet almonds (Prunus dulcis). PubMed: Honey collected from different floras of Chandigarh Tricity: a comparative study involving physicochemical parameters and biochemical activities. PubMed: Decrease of aged beer aroma by the reducing activity of brewing yeast. PubMed: Role of roasting conditions in the profile of volatile flavor chemicals formed from coffee beans. PubMed: 3-Hydroxy-4,5-dimethyl-2(5H)-furanone levels in fortified Madeira wines: relationship to sugar content. PubMed: Generation of Maillard compounds from inulin during the thermal processing of Agave tequilana Weber Var. azul. PubMed: Separation and determination of 4-methylimidazole, 2-methylimidazole and 5-hydroxymethylfurfural in beverages by amino trap column coupled with pulsed amperometric detection. PubMed: Tolerance of the Nanocellulose-Producing Bacterium Gluconacetobacter xylinus to Lignocellulose-Derived Acids and Aldehydes. PubMed: Advanced glycation end products, physico-chemical and sensory characteristics of cooked lamb loins affected by cooking method and addition of flavour precursors. PubMed: Non-targeted metabolomic reveals the effect of salt stress on global metabolite of halotolerant yeast Candida versatilis and principal component analysis. PubMed: Determination of caramel colorants' by-products in liquid foods by ultra-high-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). PubMed: Nutritional and physicochemical characteristic of commercial Spanish citrus juices. PubMed: Volatile profile of Madeira wines submitted to traditional accelerated ageing. PubMed: 5-HMF and carbohydrates content in stingless bee honey by CE before and after thermal treatment. PubMed: Properties and catalytic activity of magnetic and acidic ionic liquids: experimental and molecular simulation. PubMed: Validation of a HPLC method for determination of hydroxymethylfurfural in crude palm oil. PubMed: Tolerance of S. cerevisiae and Z. mobilis to inhibitors produced during dilute acid hydrolysis of soybean meal. PubMed: Enhancing the organoleptic and functional properties of jujube by a quick aging process. PubMed: Acrylamide, 5-hydroxymethylfurfural and N(ε)-carboxymethyl-lysine in coffee substitutes and instant coffees. PubMed: Kinetics of browning, phenolics, and 5-hydroxymethylfurfural in commercial sparkling wines. PubMed: Toxic compounds in honey. PubMed: Hydroxymethylfurfural: a possible emergent cause of honey bee mortality? PubMed: In vitro antioxidant and antiproliferative activities of 5-hydroxymethylfurfural. PubMed: Comparison of an HPTLC method with the Reflectoquant assay for rapid determination of 5-hydroxymethylfurfural in honey. PubMed: Application of a high-throughput process analytical technology metabolomics pipeline to Port wine forced ageing process. PubMed: New approaches to determination of HMF. PubMed: Developing an effective means to reduce 5-hydroxymethyl-2-furfural from caramel colour. PubMed: Isolation, structural elucidation, and biological evaluation of a 5-hydroxymethyl-2-furfural derivative, asfural, from enzyme-treated asparagus extract. PubMed: Impacts of selected dietary polyphenols on caramelization in model systems. PubMed: Physicochemical properties of the Harenna forest honey, Bale, Ethiopia. PubMed: Identification of 5-hydroxymethyl-2-furfural (5-HMF) in Cava sparkling wines by LC-DAD-MS/MS and NMR spectrometry. PubMed: Study of hydroxymethylfurfural and furfural formation in cakes during baking in different ovens, using a validated multiple-stage extraction-based analytical method. PubMed: Changes of antioxidant activity and formation of 5-hydroxymethylfurfural in honey during thermal and microwave processing. PubMed: Impact of flavour solvent (propylene glycol or triacetin) on vanillin, 5-(hydroxymethyl)furfural, 2,4-decadienal, 2,4-heptadienal, structural parameters and sensory perception of shortcake biscuits over accelerated shelf life testing. PubMed: Identification of bitter compounds in whole wheat bread. PubMed: Indirect competitive ELISA based on monoclonal antibody for the detection of 5-hydroxymethyl-2-furfural in milk, compared with HPLC. PubMed: Effect of concentration temperature on some bioactive compounds and antioxidant proprieties of date syrup. PubMed: Effects of extrusion, infrared and microwave processing on Maillard reaction products and phenolic compounds in soybean. PubMed: Industrially applicable strategies for mitigating acrylamide, furan, and 5-hydroxymethylfurfural in food. PubMed: Effect of 5-hydroxymethylfurfural derived from processed Cornus officinalis on the prevention of high glucose-induced oxidative stress in human umbilical vein endothelial cells and its mechanism. PubMed: Congeners in sugar cane spirits aged in casks of different woods. PubMed: Rapid determination of 5-hydroxymethylfurfural by DART ionization with time-of-flight mass spectrometry. PubMed: Short communication: possible mechanism for inhibiting the formation of polymers originated from 5-hydroxymethyl-2-furaldehyde by sulfite groups in the dairy thermal process. PubMed: Jujube honey from China: physicochemical characteristics and mineral contents. PubMed: Physicochemical and antioxidant properties of Malaysian honeys produced by Apis cerana, Apis dorsata and Apis mellifera. PubMed: Reactivity of thermally treated α-dicarbonyl compounds. PubMed: Untangling the chemistry of port wine aging with the use of GC-FID, multivariate statistics, and network reconstruction. PubMed: Thermal stability of anthocyanins and colourless phenolics in pomegranate (Punica granatum L.) juices and model solutions. PubMed: Determination of metabolites of 5-hydroxymethylfurfural in human urine after oral application. PubMed: Impact of cooking and handling conditions on furanic compounds in breaded fish products. PubMed: Effect of adulteration versus storage on volatiles in unifloral honeys from different floral sources and locations. PubMed: A comparison of different dilute solution explosions pretreatment for conversion of distillers' grains into ethanol. PubMed: Controlling the Maillard reaction by reactant encapsulation: sodium chloride in cookies. PubMed: Physicochemical and antioxidant properties of Bangladeshi honeys stored for more than one year. PubMed: Reporter gene mutation in the livers of gpt delta mice treated with 5-(hydroxymethyl)-2-furfural, a contaminant of various foods. PubMed: Okara promoted acrylamide and carboxymethyl-lysine formation in bakery products. PubMed: Short communication: simultaneous analysis of reducing sugars and 5-hydroxymethyl-2-furaldehyde at a low concentration by high performance anion exchange chromatography with electrochemical detector, compared with HPLC with refractive index detector. PubMed: Identification and mode of action of 5-hydroxymethyl-2-furfural (5-hmf) and 1-methyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid (MTCA) as potent xanthine oxidase inhibitors in vinegars. PubMed: Riboflavin and lumichrome in Dalmatian sage honey and other unifloral honeys determined by LC-DAD technique. PubMed: Development and validation of an HPLC method to determine metabolites of 5-hydroxymethylfurfural (5-HMF). PubMed: Volatile constituents of roasted tigernut oil (Cyperus esculentus L.). PubMed: Micellar electrokinetic chromatography method for the simultaneous determination of furanic compounds in honey and vegetable oils. PubMed: In depth study of acrylamide formation in coffee during roasting: role of sucrose decomposition and lipid oxidation. PubMed: Determination of very low levels of 5-(hydroxymethyl)-2-furaldehyde (HMF) in natural honey: comparison between the HPLC technique and the spectrophotometric white method. PubMed: 1,2-dicarbonyl compounds in commonly consumed foods. PubMed: Mutagenicity of 5-hydroxymethylfurfural in V79 cells expressing human SULT1A1: identification and mass spectrometric quantification of DNA adducts formed. PubMed: Effect of roasting conditions on color and volatile profile including HMF level in sweet almonds (Prunus dulcis). PubMed: Survey of 1,2-dicarbonyl compounds in commercial honey of different floral origin. PubMed: Effect of temperature and some added compounds on the stability of blood orange marmalade. PubMed: Kinetics of 3-deoxy-D-erythro-hexos-2-ulose in unifloral honeys. PubMed: Study of 5-hydroxymethylfurfural and its metabolite 5-sulfooxymethylfurfural on induction of colonic aberrant crypt foci in wild-type mice and transgenic mice expressing human sulfotransferases 1A1 and 1A2. PubMed: Optimization of furfural and 5-hydroxymethylfurfural production from wheat straw by a microwave-assisted process. PubMed: Simultaneous quantitation of 2-acetyl-4-tetrahydroxybutylimidazole, 2- and 4-methylimidazoles, and 5-hydroxymethylfurfural in beverages by ultrahigh-performance liquid chromatography-tandem mass spectrometry. PubMed: Analysis of roasted and unroasted Pistacia terebinthus volatiles using direct thermal desorption-GCxGC-TOF/MS. PubMed: The potential of biodetoxification activity as a probiotic property of Lactobacillus reuteri. PubMed: Degradation of 5-hydroxymethylfurfural during yeast fermentation. PubMed: Maillard reaction and protein cross-linking in relation to the solubility of milk powders. PubMed: Intestinal carcinogenesis of two food processing contaminants, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and 5-hydroxymethylfurfural, in transgenic FVB min mice expressing human sulfotransferases. PubMed: Development of an enzyme-linked immunosorbent assay for the determination of 5-hydroxymethyl-2-furfural in food. PubMed: Biological pretreatment with a cellobiose dehydrogenase-deficient strain of Trametes versicolor enhances the biofuel potential of canola straw. PubMed: Mead production: tradition versus modernity. PubMed: Thermal decomposition of 5-(hydroxymethyl)-2-furaldehyde (HMF) and its further transformations in the presence of glycine. PubMed: Hydroxymethyl-substituted furans: mutagenicity in Salmonella typhimurium strains engineered for expression of various human and rodent sulphotransferases. PubMed: Identification of H₂O₂ as a major antimicrobial component in coffee. PubMed: Fructo-oligosaccharide production from inulin through partial citric or phosphoric acid hydrolyses. PubMed: 5-Hydroxymethylfurfural content in foodstuffs determined by micellar electrokinetic chromatography. PubMed: Fast quantitation of 5-hydroxymethylfurfural in honey using planar chromatography. PubMed: Kinetic study of the thermal hydrolysis of Agave salmiana for mezcal production. PubMed: Reversible and covalent binding of 5-(hydroxymethyl)-2-furaldehyde (HMF) with lysine and selected amino acids. PubMed: Vitamin C and sugar levels as simple markers for discriminating Spanish honey sources. PubMed: Characterization of a wild strain of Alicyclobacillus acidoterrestris: heat resistance and implications for tomato juice. PubMed: Effect of antibrowning agents on browning and intermediate formation in the glucose-glutamic acid model. PubMed: Toxicology and risk assessment of 5-Hydroxymethylfurfural in food. PubMed: Effects of aldehydes on the growth and lipid accumulation of oleaginous yeast Trichosporon fermentans. PubMed: Thermal degradation characteristics and antioxidant activity of fructose solution with heating temperature and time. PubMed: nematicidal carboxylic acids and aldehydes from Melia azedarach fruits. PubMed: Use of green rooibos (Aspalathus linearis) extract and water-soluble nanomicelles of green rooibos extract encapsulated with ascorbic acid for enhanced aspalathin content in ready-to-drink iced teas. PubMed: Characterization of artisanal honey produced on the Northwest of Portugal by melissopalynological and physico-chemical data. PubMed: Optimization of extraction of apple pomace phenolics with water by response surface methodology. PubMed: Determination of some chemical parameters and antimicrobial activity of traditional food: mesir paste. PubMed: High 5-hydroxymethylfurfural concentrations are found in Malaysian honey samples stored for more than one year. PubMed: Glucose reversion reaction kinetics. PubMed: Determination of furan precursors and some thermal damage markers in baby foods: ascorbic acid, dehydroascorbic acid, hydroxymethylfurfural and furfural. PubMed: Does the pelleting process affect the nutritive value of a pre-starter diet for suckling piglets? Ex vivo studies on mineral absorption. PubMed: Quantitative determination of caffeine, formic acid, trigonelline and 5-(hydroxymethyl)furfural in soluble coffees by 1H NMR spectrometry. PubMed: Decrease of aged beer aroma by the reducing activity of brewing yeast. PubMed: Analysis, distribution, and dietary exposure of glyoxal and methylglyoxal in cookies and their relationship with other heat-induced contaminants. PubMed: Sucrose: A prospering and sustainable organic raw material. PubMed: Estimation of dietary intake of 5-hydroxymethylfurfural and related substances from coffee to Spanish population. PubMed: In vitro antioxidant activity of 5-HMF isolated from marine red alga Laurencia undulata in free-radical-mediated oxidative systems. PubMed: Physico-chemical studies on adulteration of honey in Nigeria. PubMed: Genotoxic activities of the food contaminant 5-hydroxymethylfurfural using different in vitro bioassays. PubMed: Effect of L-asparaginase on acrylamide mitigation in a fried-dough pastry model. PubMed: Simultaneous determination of melamine and 5-hydroxymethylfurfural in milk by capillary electrophoresis with diode array detection. PubMed: Assessment of hydroxymethylfurfural intake in the Spanish diet. PubMed: [Studies on chemical constituents from bee-collected rape pollen]. PubMed: Role of roasting conditions in the profile of volatile flavor chemicals formed from coffee beans. PubMed: 5-Hydroxymethylfurfural and 5-sulfooxymethylfurfural increase adenoma and flat ACF number in the intestine of Min/+ mice. PubMed: Improved method to measure aldehyde adducts to N-terminal valine in hemoglobin using 5-hydroxymethylfurfural and 2,5-furandialdehyde as model compounds. PubMed: Identification of an interfering substrate in apple juice and improvement for determination of patulin with high-performance liquid chromatography analyses. PubMed: Determination of 5-hydroxymethylfurfural using derivatization combined with polymer monolith microextraction by high-performance liquid chromatography. PubMed: Conversion of the common food constituent 5-hydroxymethylfurfural into a mutagenic and carcinogenic sulfuric acid ester in the mouse in vivo. PubMed: Development and validation of an HPLC method to quantify 3,4-dideoxyglucosone-3-ene in peritoneal dialysis fluids. PubMed: Evaluation of the DNA damaging effect of the heat-induced food toxicant 5-hydroxymethylfurfural (HMF) in various cell lines with different activities of sulfotransferases. PubMed: Influence of roasting on the antioxidant activity and HMF formation of a cocoa bean model systems. PubMed: Wheat straw autohydrolysis: process optimization and products characterization. PubMed: Evaluation of antioxidant activity, colour and some nutritional characteristics of pomegranate (Punica granatum L.) juice and its sour concentrate processed by conventional evaporation. PubMed: Degradation of 5-hydroxymethylfurfural in honey. PubMed: Simple gas chromatographic method for furfural analysis. PubMed: Dietary exposure to 5-hydroxymethylfurfural from Norwegian food and correlations with urine metabolites of short-term exposure. PubMed: Quality evaluation of different honey samples produced in Peshawar valley. PubMed: Isotope labeling studies on the formation of 5-(hydroxymethyl)-2-furaldehyde (HMF) from sucrose by pyrolysis-GC/MS. PubMed: Changes in the chemical composition of reduced cooked musts during the heating process. PubMed: Impact of caramelization on the glass transition temperature of several caramelized sugars. Part II: Mathematical modeling. PubMed: Comparative study of pulsed electric field and thermal processing of apple juice with particular consideration of juice quality and enzyme deactivation. PubMed: Estimation of hydroxymethylfurfural availability in breakfast cereals. Studies in Caco-2 cells. PubMed: Liquid chromatography multi-stage mass spectrometry for the analysis of 5-hydroxymethylfurfural in foods. PubMed: Evolution of hydroxymethylfurfural content of honeys from different climates: influence of induced granulation. PubMed: Investigation of acrylamide in curries made from coconut milk. PubMed: SULT1C3, an orphan sequence of the human genome, encodes an enzyme activating various promutagens. PubMed: The effect of various drying techniques on apricot volatiles analysed using direct thermal desorption-GC-TOF/MS. PubMed: Determination of patulin in commercial apple juice by micellar electrokinetic chromatography. PubMed: The potential antimutagenic and antioxidant effects of Maillard reaction products used as "natural antibrowning" agents. PubMed: Formation of 5-hydroxymethyl-2-furfural (HMF) and 5-hydroxymethyl-2-furoic acid during roasting of coffee. PubMed: Inhibition of polyphenoloxidase activity by mixtures of heated cysteine derivatives with carbonyl compounds. PubMed: Isolation and identification of potential cancer chemopreventive agents from methanolic extracts of green onion (Allium cepa). PubMed: Maillard reaction indicators in diets usually consumed by adolescent population. PubMed: Analysis of 5-hydroxymethylfurfural in foods by gas chromatography-mass spectrometry. PubMed: Analysis of 5-hydroxymethylfurfual in coffee, dried fruits and urine. PubMed: Study on fluorescence of Maillard reaction compounds in breakfast cereals. PubMed: Relationship between acrylamide and thermal-processing indexes in commercial breakfast cereals: a survey of Spanish breakfast cereals. PubMed: Identification and urinary excretion of metabolites of 5-(hydroxymethyl)-2-furfural in human subjects following consumption of dried plums or dried plum juice. PubMed: Diets rich in Maillard reaction products affect protein digestibility in adolescent males aged 11-14 y. PubMed: Improved method for the determination of hydroxymethylfurfural in baby foods using liquid chromatography-mass spectrometry. PubMed: Analysis of amino acids and carbohydrates in green coffee. PubMed: 5-(Hydroxymethyl)-2-furfural: a selective inhibitor of DNA polymerase lambda and terminal deoxynucleotidyltransferase. PubMed: Browning of model orange juice solution: factors affecting the formation of decomposition products. PubMed: Amla (Emblica officinalis Gaertn.) extracts reduce oxidative stress in streptozotocin-induced diabetic rats. PubMed: Honey in combination with vacuum impregnation to prevent enzymatic browning of fresh-cut apples. PubMed: Effect of storage period under variable conditions on the chemical and physical composition and colour of Spanish refrigerated orange juices. PubMed: Single laboratory validation of a method for the determination of hydroxymethylfurfural in honey by using solid-phase extraction cleanup and liquid chromatography. PubMed: Quality evaluation of honey harvested from selected areas in Tanzania with special emphasis on hydroxymethyl furfural (HMF) levels. PubMed: 3-Hydroxy-4,5-dimethyl-2(5H)-furanone levels in fortified Madeira wines: relationship to sugar content. PubMed: A benzenoid from the stem of Acanthopanax senticosus. PubMed: 1H NMR studies on Italian balsamic and traditional balsamic vinegars. PubMed: Browning and decomposed products of model orange juice. PubMed: Influence of distillation system, oak wood type, and aging time on composition of cider brandy in phenolic and furanic compounds. PubMed: 2-Furoylmethyl amino acids and hydroxymethylfurfural as indicators of honey quality. PubMed: Influence of seasonal variation on kinetics of time temperature integrators for thermally processed milk. PubMed: Thermal decomposition of specifically phosphorylated D-glucoses and their role in the control of the Maillard reaction. PubMed: Kinetics of hydroxymethylfurfural, lactulose and furosine formation in milk with different fat content. PubMed: Phytochemical composition and antioxidant stability of fortified yellow passion fruit (Passiflora edulis). PubMed: Identification and quantification of antioxidant components of honeys from various floral sources. PubMed: Interactions between cyanidin 3-O-glucoside and furfural derivatives and their impact on food color changes. PubMed: Role of aldehydic derivatives in the condensation of phenolic compounds with emphasis on the sensorial properties of fruit-derived foods. PubMed: Antioxidant effects of isorhamnetin 3,7-di-O-beta-D-glucopyranoside isolated from mustard leaf (Brassica juncea) in rats with streptozotocin-induced diabetes. PubMed: Erythritol attenuates the diabetic oxidative stress through modulating glucose metabolism and lipid peroxidation in streptozotocin-induced diabetic rats. PubMed: Generation of Maillard compounds from inulin during the thermal processing of Agave tequilana Weber Var. azul. PubMed: Formation kinetics of hydroxymethylfurfural, lactulose and furosine in milk heated under isothermal and non-isothermal conditions. PubMed: Supercritical fluid extraction of 5-hydroxymethyl-2-furaldehyde from raisins. PubMed: Derivative spectrophotometric determination of 5-(hydroxymethyl)-2-furaldehyde (HMF) and furfural in Locust bean extract. PubMed: Effects of some hydrocolloids and water activity on nonenzymic browning of concentrated orange juice. PubMed: Study of the reactions between (+)-catechin and furfural derivatives in the presence or absence of anthocyanins and their implication in food color change. PubMed: Use of 2-furoylmethyl derivatives of GABA and arginine as indicators of the initial steps of maillard reaction in orange juice. PubMed: 5-Hydroxymethylfurfural: assessment of mutagenicity, DNA-damaging potential and reactivity towards cellular glutathione. PubMed: Effects of Ca(OH)(2) treatments ("overliming") on the composition and toxicity of bagasse hemicellulose hydrolysates. PubMed: Confirmation of patulin and 5-hydroxymethylfurfural in apple juice by gas chromatography/mass spectrometry. PubMed: Effect of hexanal and iron on color development in a glucose/phenylalanine model system. PubMed: Hydroxymethylfurfural and furosine reaction kinetics in tomato products. PubMed: Study of the formation mechanisms of some volatile compounds during the aging of sweet fortified wines. PubMed: Effects of L-cysteine and N-acetyl-L-cysteine on 4-hydroxy-2, 5-dimethyl-3(2H)-furanone (furaneol), 5-(hydroxymethyl)furfural, and 5-methylfurfural formation and browning in buffer solutions containing either rhamnose or glucose and arginine. PubMed: Phenolic constituents, furans, and total antioxidant status of distilled spirits. PubMed: Analysis of furanone, pyranone, and new heterocyclic colored compounds from sugar-glycine model Maillard systems. PubMed: Effect of selected aldehydes on the growth and fermentation of ethanologenic Escherichia coli. PubMed: Simultaneous determination of 5-hydroxymethylfurfural and patulin in apple juice by reversed-phase liquid chromatography. PubMed: Distribution and metabolism of (5-hydroxymethyl)furfural in male F344 rats and B6C3F1 mice after oral administration. PubMed: Rapid reversed-phase liquid chromatographic determination of patulin in apple juice. PubMed: Bioactivation of 5-hydroxymethyl-2-furaldehyde to an electrophilic and mutagenic allylic sulfuric acid ester. PubMed: Semiautomatic determination of furanic aldehydes in food and pharmaceutical samples by a stopped-flow injection analysis method. PubMed: Detection and determination of interfering 5-hydroxymethylfurfural in the analysis of caramel-coloured pharmaceutical syrups. PubMed: Toxicity potential of compounds found in parenteral solutions with rubber stoppers. PubMed: Reversed-phase high-performance liquid chromatographic method for the quantification of 5-hydroxymethylfurfural as the major degradation product of glucose in infusion fluids. PubMed: Influence of water activity and reaction temperature of ribose-lysine and glucose-lysine Maillard systems on mutagenicity, absorbance and content of furfurals. PubMed: [Formation of hydroxymethylfurfural during the storage and processing of food products]. PubMed: Desmutagenic effect of alpha-dicarbonyl and alpha-hydroxycarbonyl compounds against mutagenic heterocyclic amines. PubMed: Rapid and complete urinary elimination of [14C]-5-hydroxymethyl-2-furaldehyde administered orally or intravenously to rats. PubMed: High performance liquid chromatography of furfural and hydroxymethylfurfural in spirits and honey. PubMed: Hydroxymethylfurfural and honey adulteration. PubMed: [Hygienic significance of patulin in foods. 1. Analytical detection of patulin].