Identification

Namephenyl salicylate
IUPACphenyl 2-hydroxybenzoate
CAS Number118-55-8
EINECS204-259-2
FDA UNII28A37T47QO
Molecular FormulaC13 H10 O3
Molecular Weight214.22030000
MDL NumberMFCD00002213
Nikkaji NumberJ5.300G
Beilstein0393969
CoE Number11814
XlogP33.80 (est)

Regulatory

JECFA Food Flavoring736 phenyl salicylate
DG SANTE Food Flavourings09.689 phenyl salicylate
FEMA Number3960
FDANo longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm (SATF)118-55-8 ; PHENYL SALICYLATE
FDA RegulationFDA PART 177 -- INDIRECT FOOD ADDITIVES: POLYMERS

Physical Properties

Appearance colorless crystalline solid (est)
Assay 99.00 to 100.00
Food Chemicals Codex Listed No
Melting Point 43.00 to 46.00 °C. @ 760.00 mm Hg
Boiling Point 172.00 to 173.00 °C. @ 12.00 mm Hg, 304.00 to 306.00 °C. @ 760.00 mm Hg
Acid Value 1.00 max. KOH/g
Vapor Pressure 0.000421 mmHg @ 25.00 °C. (est)
Flash Point > 212.00 °F. TCC ( > 100.00 °C. )
logP (o/w) 3.292 (est)
Soluble in alcohol
Insoluble in water
Similar Items note

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesantimicrobial agents

Organoleptic Properties

Odor Description at 100.00 %.

Safety Information

Preferred SDSView
European informationMost important hazard(s):
Oral/Parenteral Toxicityoral-rat LD50 3000 mg/kg
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryantimicrobial agents
RIFM Fragrance Material Safety AssessmentSearch
maximum skin levels for fine fragrances0.0200 % and are based on the assumption that the fragrance mixture is used at 20% in a consumer product (IFRA Use Level Survey).
Recommendation for phenyl salicylate usage levels up to2.0000 % in the fragrance concentrate.
use level in formulae for use in cosmetics0.0200 %
Dermal Systemic Exposure in Cosmetic Products0.0005 mg/kg/day
Maximised Survey-derived Daily Intakes (MSDI-EU)7.30 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA)8.00 (μg/capita/day)
baked goods40.00000
beverages(nonalcoholic)40.00000
beverages(alcoholic)40.00000
breakfast cereal40.00000
cheese-
chewing gum400.00000
condiments / relishes-
confectionery froastings40.00000
egg products-
fats / oils-
fish products-
frozen dairy-
fruit ices-
gelatins / puddings-
granulated sugar-
gravies-
hard candy40.00000
imitation dairy-
instant coffee / tea-
jams / jellies-
meat products-
milk products40.00000
nut products-
other grains-
poultry-
processed fruits-
processed vegetables-
reconstituted vegetables-
seasonings / flavors-
snack foods-
soft candy40.00000
soups-
sugar substitutes-
sweet sauces-

Berje Inc.

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Fleurchem, Inc.

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Potential Uses

antimicrobial agents FR balsam denaturants FR fruit FR herbal intensifier FR wintergreen

Natural Occurrence

not found in nature

Synonyms

benzoic acid, 2-hydroxy-, phenyl ester 2- hydroxybenzoic acid phenyl ester 2- hydroxybenzoic acid, phenyl ester musol phenol salicylate 2- phenoxycarbonyl phenol 2- phenoxycarbonylphenol phenyl 2-hydroxybenzoate phenyl-alpha-hydroxybenzoate salicylic acid phenyl ester salicylic acid, phenyl ester salol salphenyl seesorb 201 seesorb K 201 PubMed: Kinetics and Mechanism of the Flexible Nanoparticle-Catalyzed Piperidinolysis of Anionic Phenyl Salicylate. PubMed: Kinetics and mechanism of nanoparticles-catalyzed piperidinolysis of anionic phenyl salicylate. PubMed: A universal modified van der Waals equation of state. Part I: Polymer and mineral glass formers. PubMed: Transition from Arrhenius to non-Arrhenius temperature dependence of structural relaxation time in glass-forming liquids: continuous versus discontinuous scenario. PubMed: Study of the transformation of two salicylates used in personal care products in chlorinated water. PubMed: Screening alternative therapies to control Nosemosis type C in honey bee (Apis mellifera iberiensis) colonies. PubMed: Simultaneous determination of the UV-filters benzyl salicylate, phenyl salicylate, octyl salicylate, homosalate, 3-(4-methylbenzylidene) camphor and 3-benzylidene camphor in human placental tissue by LC-MS/MS. Assessment of their in vitro endocrine activity. PubMed: Phenyl salicylates - a new group of potential antituberculotics. PubMed: Synthesis of biologically active and photostable rigid poly(vinyl chloride). PubMed: Modeling dynamics of isotropic dielectrics in a laminar heterogeneous configuration. PubMed: The estrogenic potential of salicylate esters and their possible risks in foods and cosmetics. PubMed: Temperature dependence of the Landau-Placzek ratio in glass forming liquids. PubMed: Positron annihilation response and broadband dielectric spectroscopy: salol. PubMed: The role of nucleation in vitrification of supercooled liquids. PubMed: Kinetic and rheological measurements of the effects of inert 2-, 3- and 4-bromobenzoate ions on the cationic micellar-mediated rate of piperidinolysis of ionized phenyl salicylate. PubMed: A new semi-empirical kinetic method for the determination of ion exchange constants for the counterions of cationic micelles. PubMed: Determination of an ion exchange constant by the use of a kinetic probe: a new semiempirical kinetic approach involving the effects of 3-F- and 4-F-substituted benzoates on the rate of piperidinolysis of anionic phenyl salicylate in aqueous cationic micelles. PubMed: Infrared spectroscopy study of structural changes in glass-forming salol. PubMed: Density scaling and dynamic correlations in viscous liquids. PubMed: Kinetic evidence for the occurrence of independent ion-exchange processes in the cationic micellar-mediated reaction of piperidine with anionic phenyl salicylate. PubMed: The temperature dependence of free volume in phenyl salicylate and its relation to structural dynamics: a positron annihilation lifetime and pressure-volume-temperature study. PubMed: A direct test of the correlation between elastic parameters and fragility of ten glass formers and their relationship to elastic models of the glass transition. PubMed: Facilitation, complexity growth, mode coupling, and activated dynamics in supercooled liquids. PubMed: Preparation of lipophilic alkyl (hydroxy)benzoates by solvent-free lipase-catalyzed esterification and transesterification. PubMed: Mass spectrometric identification of covalent adducts of the skin allergen 2,4-dinitro-1-chlorobenzene and model skin proteins. PubMed: Fragrance material review on phenyl salicylate. PubMed: Degradation kinetics of hydrolytically susceptible drugs in O/W emulsions--effects of interfacial area and lecithin. PubMed: Investigating protein haptenation mechanisms of skin sensitisers using human serum albumin as a model protein. PubMed: Depolarized light scattering versus optical Kerr effect spectroscopy of supercooled liquids: comparative analysis. PubMed: Cole-Cole law for critical dynamics in glass-forming liquids. PubMed: Pharmaceutical quality control of acid and neutral drugs based on competitive self-assembly in amphiphilic systems. PubMed: Interfacial effects on vitrification of confined glass-forming liquids. PubMed: Slow dynamics of salol: a pressure- and temperature-dependent light scattering study. PubMed: Brillouin scattering study of salol: exploring the effects of rotation-translation coupling. PubMed: Can experiments select the configurational component of excess entropy? PubMed: Viscosity at the dynamic crossover in o-terphenyl and salol under high pressure. PubMed: Nearly logarithmic decay of correlations in glass-forming liquids. PubMed: Effect of ultraviolet light absorbers on photostabilization of azadirachtin-A in solution (part: II). PubMed: [Determination of 4 antiseptics and 6 sunscreen agents in cosmetic products by reversed-phase high performance liquid chromatography]. PubMed: Effect of some ultraviolet light absorbers on photo-stabilization of azadirachtin-A. PubMed: Temperature and pressure dependence of the alpha relaxation and configurational entropy of a prototype glass former. PubMed: [Determination of sunscreen agents in cosmetic products by reversed-phase high performance liquid chromatography]. PubMed: Orientational dynamics in supercooled liquids near T(c) and comparison with ideal mode-coupling theory PubMed: Effects of PubMed: Effects of Nonionic, Cationic, and Mixed Nonionic-Cationic Surfactants on the Acid-Base Behavior of Phenyl Salicylate. PubMed: Effects of [NaOH] and [KBr] on Intramolecular General Base-Catalyzed Methanolysis of Ionized Phenyl Salicylate in the Presence of Cationic Micelles. PubMed: Screening of antiadherent activity on Streptococcus sobrinus culture. PubMed: Neighboring group catalysis in the design of nucleotide prodrugs. PubMed: The effectiveness of benzyl benzoate and different chemicals as acaricides. PubMed: [Stability of phenyl salicylate in alcoholic-aqueous solution]. PubMed: Biologic testing of leachable aromatic compounds from denture base materials. PubMed: Tc of the mode coupling theory evaluated from impulsive stimulated light scattering on salol. PubMed: Leaching from denture base materials in vitro. PubMed: Reply to "Comment on 'Light-scattering investigation of alpha and beta relaxation near the liquid-glass transition of the molecular glass Salol' " and "Reexamination of the depolarized-light-scattering spectra of glass-forming liquids" PubMed: Comment on "Light-scattering investigation of alpha and beta relaxation near the liquid-glass transition of the molecular glass Salol" PubMed: Leaching of additives and degradation products from cold-cured orthodontic resins. PubMed: Light-scattering spectroscopy of the liquid-glass transition in CaKNO3 and in the molecular glass Salol: Extended-mode-coupling-theory analysis. PubMed: Brillouin scattering in salol: Determining Tc of the mode coupling theory. PubMed: Light-scattering investigation of alpha and beta relaxation near the liquid-glass transition of the molecular glass Salol. PubMed: Cross-sensitivity between resorcinol, resorcinol monobenzoate and phenyl salicylate. PubMed: Specific-heat spectroscopy and dielectric susceptibility measurements of salol at the glass transition. PubMed: Contact dermatitis from phenyl salicylate in a galenic cream. PubMed: Direct observation of microbubbles in directional solidification of salol. PubMed: Synthesis and evaluation of the analgesic and antiinflammatory activities of N,N'-bis(2-hydroxybenzoyl)-diaminoalkanes. PubMed: Light scattering study of the glass transition in salol. PubMed: Synthesis and evaluation of the analgesic and antiinflammatory activities of N-substituted salicylamides. PubMed: Spectrophotometric determination of alkyl salicylate from the mixture of phenyl and alkyl salicylates by the use of the selective reactivity of phenyl salicylate toward secondary amines. PubMed: Bile salt roles in bile-salt-stimulated lipase activity. PubMed: Dermatitis from phenyl salicylate in safety spectacle frames. PubMed: [Novel N-pyrazolylsalicylamides with antifungal activity]. PubMed: Transesterification: an analytical and formulation problem. PubMed: High-performance liquid chromatographic analysis of iodochlorhydroxyquin and hydrocortisone in ointments and creams. PubMed: Allergic contact dermatitis to various salols (phenyl salicylates). A structure-activity relationship study in man and in animal (guinea pig). PubMed: Allergy to phenyl salicylate. PubMed: In vitro transformation of hamster embryo cells by 3-(N-salicyloyl)amino-1,2,4-triazole. PubMed: Phenyl salicylate (Salol) in a lip salve. PubMed: Potassium hydroxide solution 10% for the fast hydrolysis of esters for analysis. PubMed: Elevated urinary phenol levels in beagle dogs treated with salol. PubMed: Elevated urinary phenol levels not related to benzene exposure. PubMed: Reactions to aspirin and food additives in patients with chronic urticaria, including the physical urticarias. PubMed: Fluroescence of phenyl salicylate. PubMed: [Aluminiumlactate and salol for the prevention of periodontal diseases, AGEPHA oral hygiene drugs]. PubMed: [Assays of sodium noraminophenazone methanesulphonate, phenyl salicylate and papaverine hydrochloride in compound prescription forms]. PubMed: Experimental production of malformations due to acetyl salicylate and phenyl salicylate in rats. PubMed: [Effect of additional components and of the granulation method on some properties of salol tablets]. PubMed: [Effect of aspirin and salol on gastrointestinal secretion in normal conditions and in experimental fever]. PubMed: [Possibilities of determination of salol in combination with thymol and chloride of pilocarpine in combination with chloride of novocaine]. PubMed: The salol reaction. PubMed: THE INFLUENCE OF BILE ON METABOLISM. PubMed: The Treatment of Small-Pox by Salol. PubMed: Salol Calculi.