1,4,5,6-tetrahydro-2-methyl-4-pyrimidinecarboxylic acid

CAS: 96702-03-3 C6 H10 N2 O2 MW: 142.15810000

Identification

Nameectoin
IUPAC(6S)-2-methyl-1,4,5,6-tetrahydropyrimidine-6-carboxylic acid
CAS Number96702-03-3
FDA UNII7GXZ3858RY
Molecular FormulaC6 H10 N2 O2
Molecular Weight142.15810000
MDL NumberMFCD03419286
Nikkaji NumberJ659.626F
Beilstein7288977

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Soluble in water, 2.048e+004 mg/L @ 25 °C (est)

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesskin conditioning

No sensory data available

Safety Information

Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorycosmetic ingredient for skin conditioning
Recommendation for ectoin usage levels up tonot for fragrance use.
Recommendation for ectoin flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

not found in nature

Synonyms

(6S)-2- methyl-1,4,5,6-tetrahydropyrimidine-6-carboxylic acid 4- pyrimidinecarboxylic acid, 1,4,5,6,-tetrahydro-2-methyl-, (4S)- 1,4,5,6- tetrahydro-2-methyl-4-pyrimidinecarboxylic acid Google Patents: Ectoin and ectoin derivatives as moisturizers in cosmetics PubMed: Reduction of neutrophilic lung inflammation by inhalation of the compatible solute ectoine: a randomized trial with elderly individuals. PubMed: Serum-free non-toxic freezing solution for cryopreservation of human adipose tissue-derived mesenchymal stem cells. PubMed: Actinobacteria from Arid and Desert Habitats: Diversity and Biological Activity. PubMed: Genomic analysis of the nitrate-respiring Sphingopyxis granuli (formerly Sphingomonas macrogoltabida) strain TFA. PubMed: Cryopreservation of hMSCs seeded silk nanofibers based tissue engineered constructs. PubMed: Challenges to design and develop of DNA aptamers for protein targets. I. Optimization of asymmetric PCR for generation of a single stranded DNA library. PubMed: Stability of lysozyme in aqueous extremolyte solutions during heat shock and accelerated thermal conditions. PubMed: Effects of non-toxic cryoprotective agents on the viability of cord blood derived MNCs. PubMed: The active natural anti-oxidant properties of chamomile, milk thistle, and halophilic bacterial components in human skin in vitro. PubMed: [Production and characterization of Methylomicrobium alcaliphilum 20Z knockout mutants, which has sucrose and ectoin synthesis defective genes]. PubMed: A prospective, controlled study of SNS01 (ectoine nasal spray) compared to BNO-101 (phytotherapeutic dragées) in patients with acute rhinosinusitis. PubMed: Video analysis of osmotic cell response during cryopreservation. PubMed: Systematic parameter optimization of a Me(2)SO- and serum-free cryopreservation protocol for human mesenchymal stem cells. PubMed: Alternatives to dimethylsulfoxide for serum-free cryopreservation of human mesenchymal stem cells. PubMed: [Biosynthesis of the bioprotectant ectoin by aerobic methylotrophic bacteria from methanol]. PubMed: The compatible solute ectoine protects against nanoparticle-induced neutrophilic lung inflammation. PubMed: Genotoxicity of visible light (400-800 nm) and photoprotection assessment of ectoin, L-ergothioneine and mannitol and four sunscreens. PubMed: In vivo assessment of Ectoin: a randomized, vehicle-controlled clinical trial. PubMed: [Vitamin B12-independent strains of Methylophaga marina isolated from Red Sea algae]. PubMed: Screening of novel excipients for improving the stability of retroviral and adenoviral vectors. PubMed: [Biotechnological potential of methylotrophic bacteria: a review of current status and future prospects]. PubMed: Ectoin: an effective natural substance to prevent UVA-induced premature photoaging. PubMed: Detection of ectoin biosynthesis genes in halotolerant aerobic methylotrophic bacteria.