N-feruloyl serotonin
2-propenamide, N-(2-(5-hydroxy-1H-indol-3-yl)ethyl)-3-(4-hydroxy-3-methoxyphenyl)-, (E)-
Identification
| Name | N-feruloyl serotonin |
| IUPAC | (E)-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-3-(4-hydroxy-3-methoxyphenyl)prop-2-enamide |
| CAS Number | 193224-22-5 |
| FDA UNII | 2PP8322487 |
| Molecular Formula | C20 H20 N2 O4 |
| Molecular Weight | 352.39020000 |
| Nikkaji Number | J1.973.598B |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Soluble in | water, 198.1 mg/L @ 25 °C (est) |
Cosmetic Information
| CosIng | cosmetic data |
| Cosmetic Uses | skin protecting agents |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | cosmetic ingredient for skin protecting |
| Recommendation for N-feruloyl serotonin usage levels up to | not for fragrance use. |
| Recommendation for N-feruloyl serotonin flavor usage levels up to | not for flavor use. |
BOC Sciences
Best of Chemicals Supplier
Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecul...
Potential Uses
Natural Occurrence
Synonyms
N-
feruloylserotonin
(E)-N-[2-(5-
hydroxy-1H-indol-3-yl)ethyl]-3-(4-hydroxy-3-methoxyphenyl)prop-2-enamide
moschamine
2-
propenamide, N-(2-(5-hydroxy-1H-indol-3-yl)ethyl)-3-(4-hydroxy-3-methoxyphenyl)-, (2E)-
2-
propenamide, N-(2-(5-hydroxy-1H-indol-3-yl)ethyl)-3-(4-hydroxy-3-methoxyphenyl)-, (E)-
PubMed:
Phytochemistry and Pharmacology of Carthamus tinctorius L.
PubMed:
On the pharmacology of oxidative burst of human neutrophils.
PubMed:
Preparative Separation of N-Feruloyl Serotonin and N-(p-Coumaroyl) Serotonin from Safflower Seed Meal Using High-Speed Counter-Current Chromatography.
PubMed:
N-feruloylserotonin in preventive combination therapy with methotrexate reduced inflammation in adjuvant arthritis.
PubMed:
Polyphenol derivatives - potential regulators of neutrophil activity.
PubMed:
Decreased activity and accelerated apoptosis of neutrophils in the presence of natural polyphenols.
PubMed:
Study on the hypochlolesterolemic and antioxidative effects of tyramine derivatives from the root bark of Lycium chenese Miller.
PubMed:
Synthesis, biological activities and bioavailability of moschamine, a safflomide-type phenylpropenoic acid amide found in Centaurea cyanus.
PubMed:
Naturally appearing N-feruloylserotonin isomers suppress oxidative burst of human neutrophils at the protein kinase C level.
PubMed:
Effect of N-(p-coumaroyl)serotonin and N-feruloylserotonin, major anti-atherogenic polyphenols in safflower seed, on vasodilation, proliferation and migration of vascular smooth muscle cells.
PubMed:
Methanol elicits the biosynthesis of 4-coumaroylserotonin and feruloylserotonin in rice seedlings.
PubMed:
Suppression of oxidative burst in human neutrophils with the naturally occurring serotonin derivative isomer from Leuzea carthamoides.
PubMed:
Effects of safflower seed extract on arterial stiffness.
PubMed:
Beta-D-glucosidase-catalyzed deglucosidation of phenylpropanoid amides of 5-hydroxytryptamine glucoside in safflower seed extracts optimized by response surface methodology.
PubMed:
Safflower seed polyphenols (N-(p-coumaroyl)serotonin and N-feruloylserotonin) ameliorate atherosclerosis and distensibility of the aortic wall in Kurosawa and Kusanagi-hypercholesterolemic (KHC) rabbits.
PubMed:
Protective effect of serotonin derivatives on glucose-induced damage in PC12 rat pheochromocytoma cells.
PubMed:
Inhibitory effect of serotonin derivatives on high glucose-induced adhesion and migration of monocytes on human aortic endothelial cells.
PubMed:
The selective effect of N-feruloylserotonins isolated from Leuzea carthamoides on nociception and anxiety in rats.
PubMed:
Serotonin derivatives, major safflower (Carthamus tinctorius L.) seed antioxidants, inhibit low-density lipoprotein (LDL) oxidation and atherosclerosis in apolipoprotein E-deficient mice.
PubMed:
Inhibitory effects of active compounds isolated from safflower (Carthamus tinctorius L.) seeds for melanogenesis.
PubMed:
Phenylpropanoid amides of serotonin accumulate in witches' broom diseased bamboo.
PubMed:
High-performance liquid chromatographic analysis and separation of N-feruloylserotonin isomers.