glycerol formal, alpha,alpha'

1,3-dioxolane-4-methanol

CAS: 4740-78-7 C4 H8 O3 MW: 104.10536000

Identification

Nameglycerol formal, alpha,alpha'
IUPAC1,3-dioxan-5-ol
CAS Number4740-78-7
EINECS225-248-9
FDA UNIIF6UP32GBII
Molecular FormulaC4 H8 O3
Molecular Weight104.10536000
MDL NumberMFCD10039829
Nikkaji NumberJ262.422B

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Soluble in water, 1e+006 mg/L @ 25 °C (est)

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesantimicrobial agents

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryantimicrobial agents
Recommendation for glycerol formal, alpha,alpha' usage levels up tonot for fragrance use.
Recommendation for glycerol formal, alpha,alpha' flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

not found in nature ulva rigida oil greece @ 11.80% Data PMC

Synonyms

1,3- dioxan-5-ol 5-m- dioxanol 1,3- dioxolane-4-methanol 1,3- formalglycerol PubMed: Synthesis of the Fatty Esters of Solketal and Glycerol-Formal: Biobased Specialty Chemicals. PubMed: Green acetylation of solketal and glycerol formal by heterogeneous acid catalysts to form a biodiesel fuel additive. PubMed: Evaluation of degradation kinetics for abamectin in formulations using a stability indicating method. PubMed: Neurotoxic effects of ivermectin administration in genetically engineered mice with targeted insertion of the mutated canine ABCB1 gene. PubMed: Multi-seasonal barnacle (Balanus improvisus) protection achieved by trace amounts of a macrocyclic lactone (ivermectin) included in rosin-based coatings. PubMed: The influence of co-solvents on the stability and bioavailability of rapamycin formulated in self-microemulsifying drug delivery systems. PubMed: Age, dose, and time-dependency of plasma and tissue distribution of deltamethrin in immature rats. PubMed: Delivery of resveratrol, a red wine polyphenol, from solutions and hydrogels via the skin. PubMed: Toxicokinetics and tissue distribution of deltamethrin in adult Sprague-Dawley rats. PubMed: Ivermectin (3.15%) long-acting formulations in cattle: absorption pattern and pharmacokinetic considerations. PubMed: Cardiovascular effects of selected water-miscible solvents for pharmaceutical injections and embolization materials: a comparative hemodynamic study using a sheep model. PubMed: Formulation-dependent toxicokinetics explains differences in the GI absorption, bioavailability and acute neurotoxicity of deltamethrin in rats. PubMed: Development and evaluation of emulsion-liposome blends for resveratrol delivery. PubMed: Ontogeny of hepatic and plasma metabolism of deltamethrin in vitro: role in age-dependent acute neurotoxicity. PubMed: Isotropic systems of medium-chain mono- and diglycerides for solubilization of lipophilic and hydrophilic drugs. PubMed: The effect of Calcicol as calcium tonic on delayed neurotoxicity induced by organophosphorus compounds. PubMed: Comparative hemolytic activity of undiluted organic water-miscible solvents for intravenous and intra-arterial injection. PubMed: Organic solvents for pharmaceutical parenterals and embolic liquids: a review of toxicity data. PubMed: Stable prodrugs of n-butyric acid: suppression of T cell alloresponses in vitro and prolongation of heart allograft survival in a fully allogeneic rat strain combination. PubMed: Bioequivalence of ivermectin formulations in pigs and cattle. PubMed: Protective effect of pralidoxime on muscle fiber necrosis induced by organophosphate compounds. PubMed: Potentiation of organophosphorus compound-induced delayed neurotoxicity (OPIDN) in the central and peripheral nervous system of the adult hen: distribution of axonal lesions. PubMed: Clastogenic and aneugenic effects of tamoxifen and some of its analogues in hepatocytes from dosed rats and in human lymphoblastoid cells transfected with human P450 cDNAs (MCL-5 cells). PubMed: Effect of omeprazole on sodium and potassium output in pentagastrin-stimulated equine gastric contents. PubMed: Vehicle and route dependent effects of a pyrethroid insecticide, deltamethrin, on motor function in the rat. PubMed: Viscoelastic properties of poly(ethylene oxide) solution. PubMed: Viscoelastic properties of polyacrylic acid gels in mixed solvents. PubMed: Inotropic and chronotropic effect of glycerol formal on the isolated rabbit heart. PubMed: Teratogenic assessment of four solvents using the Frog Embryo Teratogenesis Assay--Xenopus (FETAX). PubMed: Mixture experimental design in the development of a mucoadhesive gel formulation. PubMed: Effects of glycerolformal on sympathetic neurotransmission in the isolated rabbit heart. PubMed: Cardiovascular action of penta-O-ethylquercetin in the rat. PubMed: Topical application of penetration enhancers to the skin of nude mice: a histopathological study. PubMed: [Pharmacologic effects of glycerolformal on the central nervous system]. PubMed: Bioavailability and tissue elimination of chloramphenicol following parenteral administration in the preruminant calf. PubMed: Anti-strongyle activity of a propylene glycol-glycerol formal formulation of ivermectin in horses (mares). PubMed: Inactivity of glycerol formal in a mouse micronucleus assay: relationship to its teratogenicity. PubMed: [Toxico-pharmacological study of glycerolformal]. PubMed: Mass spectrometric techniques in solving drug metabolism problems. PubMed: [Action of glycerolformal on the cardiovascular system]. PubMed: Separation and determination of the two components of glycerol formal by high-performance liquid chromatography. PubMed: Toxicological studies of deltamethrin. PubMed: Histopathologic features of canine heartworm microfilarial infection after treatment with ivermectin. PubMed: Gas-liquid chromatography-chemical ionization selected ion monitoring assay for glycerol formal in animal tissues. PubMed: Biochemical and biomedical applications of capillary column GLC using SIM. PubMed: Elevated cerebellar cyclic GMP levels during the deltamethrin-induced motor syndrome. PubMed: Morphogenesis of aortic arch malformations in rat embryos after maternal treatment with glycerol formal during pregnancy. PubMed: Effects of glycerol formal on embryonic development in the rat. PubMed: Cardiovascular malformations experimentally induced in the rat. PubMed: The loss of creatine phosphokinase (CK) from intramuscular injection sites in rabbits. A predictive tool for local toxicity. PubMed: [Effect of glycerol formal on the embryonic development of the rat]. PubMed: Glycerol formal as a solvent for detoxification of isoniazid. PubMed: The dietary toxicity of glycerol formal in the rat. PubMed: A note on glycerol formal as a solvent in toxicity testing.