glycerol formal, alpha,alpha'
1,3-dioxolane-4-methanol
Identification
| Name | glycerol formal, alpha,alpha' |
| IUPAC | 1,3-dioxan-5-ol |
| CAS Number | 4740-78-7 |
| EINECS | 225-248-9 |
| FDA UNII | F6UP32GBII |
| Molecular Formula | C4 H8 O3 |
| Molecular Weight | 104.10536000 |
| MDL Number | MFCD10039829 |
| Nikkaji Number | J262.422B |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Soluble in | water, 1e+006 mg/L @ 25 °C (est) |
Cosmetic Information
| CosIng | cosmetic data |
| Cosmetic Uses | antimicrobial agents |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | antimicrobial agents |
| Recommendation for glycerol formal, alpha,alpha' usage levels up to | not for fragrance use. |
| Recommendation for glycerol formal, alpha,alpha' flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
1,3-
dioxan-5-ol
5-m-
dioxanol
1,3-
dioxolane-4-methanol
1,3-
formalglycerol
PubMed:
Synthesis of the Fatty Esters of Solketal and Glycerol-Formal: Biobased Specialty Chemicals.
PubMed:
Green acetylation of solketal and glycerol formal by heterogeneous acid catalysts to form a biodiesel fuel additive.
PubMed:
Evaluation of degradation kinetics for abamectin in formulations using a stability indicating method.
PubMed:
Neurotoxic effects of ivermectin administration in genetically engineered mice with targeted insertion of the mutated canine ABCB1 gene.
PubMed:
Multi-seasonal barnacle (Balanus improvisus) protection achieved by trace amounts of a macrocyclic lactone (ivermectin) included in rosin-based coatings.
PubMed:
The influence of co-solvents on the stability and bioavailability of rapamycin formulated in self-microemulsifying drug delivery systems.
PubMed:
Age, dose, and time-dependency of plasma and tissue distribution of deltamethrin in immature rats.
PubMed:
Delivery of resveratrol, a red wine polyphenol, from solutions and hydrogels via the skin.
PubMed:
Toxicokinetics and tissue distribution of deltamethrin in adult Sprague-Dawley rats.
PubMed:
Ivermectin (3.15%) long-acting formulations in cattle: absorption pattern and pharmacokinetic considerations.
PubMed:
Cardiovascular effects of selected water-miscible solvents for pharmaceutical injections and embolization materials: a comparative hemodynamic study using a sheep model.
PubMed:
Formulation-dependent toxicokinetics explains differences in the GI absorption, bioavailability and acute neurotoxicity of deltamethrin in rats.
PubMed:
Development and evaluation of emulsion-liposome blends for resveratrol delivery.
PubMed:
Ontogeny of hepatic and plasma metabolism of deltamethrin in vitro: role in age-dependent acute neurotoxicity.
PubMed:
Isotropic systems of medium-chain mono- and diglycerides for solubilization of lipophilic and hydrophilic drugs.
PubMed:
The effect of Calcicol as calcium tonic on delayed neurotoxicity induced by organophosphorus compounds.
PubMed:
Comparative hemolytic activity of undiluted organic water-miscible solvents for intravenous and intra-arterial injection.
PubMed:
Organic solvents for pharmaceutical parenterals and embolic liquids: a review of toxicity data.
PubMed:
Stable prodrugs of n-butyric acid: suppression of T cell alloresponses in vitro and prolongation of heart allograft survival in a fully allogeneic rat strain combination.
PubMed:
Bioequivalence of ivermectin formulations in pigs and cattle.
PubMed:
Protective effect of pralidoxime on muscle fiber necrosis induced by organophosphate compounds.
PubMed:
Potentiation of organophosphorus compound-induced delayed neurotoxicity (OPIDN) in the central and peripheral nervous system of the adult hen: distribution of axonal lesions.
PubMed:
Clastogenic and aneugenic effects of tamoxifen and some of its analogues in hepatocytes from dosed rats and in human lymphoblastoid cells transfected with human P450 cDNAs (MCL-5 cells).
PubMed:
Effect of omeprazole on sodium and potassium output in pentagastrin-stimulated equine gastric contents.
PubMed:
Vehicle and route dependent effects of a pyrethroid insecticide, deltamethrin, on motor function in the rat.
PubMed:
Viscoelastic properties of poly(ethylene oxide) solution.
PubMed:
Viscoelastic properties of polyacrylic acid gels in mixed solvents.
PubMed:
Inotropic and chronotropic effect of glycerol formal on the isolated rabbit heart.
PubMed:
Teratogenic assessment of four solvents using the Frog Embryo Teratogenesis Assay--Xenopus (FETAX).
PubMed:
Mixture experimental design in the development of a mucoadhesive gel formulation.
PubMed:
Effects of glycerolformal on sympathetic neurotransmission in the isolated rabbit heart.
PubMed:
Cardiovascular action of penta-O-ethylquercetin in the rat.
PubMed:
Topical application of penetration enhancers to the skin of nude mice: a histopathological study.
PubMed:
[Pharmacologic effects of glycerolformal on the central nervous system].
PubMed:
Bioavailability and tissue elimination of chloramphenicol following parenteral administration in the preruminant calf.
PubMed:
Anti-strongyle activity of a propylene glycol-glycerol formal formulation of ivermectin in horses (mares).
PubMed:
Inactivity of glycerol formal in a mouse micronucleus assay: relationship to its teratogenicity.
PubMed:
[Toxico-pharmacological study of glycerolformal].
PubMed:
Mass spectrometric techniques in solving drug metabolism problems.
PubMed:
[Action of glycerolformal on the cardiovascular system].
PubMed:
Separation and determination of the two components of glycerol formal by high-performance liquid chromatography.
PubMed:
Toxicological studies of deltamethrin.
PubMed:
Histopathologic features of canine heartworm microfilarial infection after treatment with ivermectin.
PubMed:
Gas-liquid chromatography-chemical ionization selected ion monitoring assay for glycerol formal in animal tissues.
PubMed:
Biochemical and biomedical applications of capillary column GLC using SIM.
PubMed:
Elevated cerebellar cyclic GMP levels during the deltamethrin-induced motor syndrome.
PubMed:
Morphogenesis of aortic arch malformations in rat embryos after maternal treatment with glycerol formal during pregnancy.
PubMed:
Effects of glycerol formal on embryonic development in the rat.
PubMed:
Cardiovascular malformations experimentally induced in the rat.
PubMed:
The loss of creatine phosphokinase (CK) from intramuscular injection sites in rabbits. A predictive tool for local toxicity.
PubMed:
[Effect of glycerol formal on the embryonic development of the rat].
PubMed:
Glycerol formal as a solvent for detoxification of isoniazid.
PubMed:
The dietary toxicity of glycerol formal in the rat.
PubMed:
A note on glycerol formal as a solvent in toxicity testing.