cis-6-hexadecenoic acid
sapienic acid
Identification
| Name | cis-6-hexadecenoic acid |
| IUPAC | (Z)-hexadec-6-enoic acid |
| CAS Number | 17004-51-2 |
| FDA UNII | 6460S1EJ28 |
| Molecular Formula | C16 H30 O2 |
| Molecular Weight | 254.41350000 |
| Nikkaji Number | J1.257.605F |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Soluble in | water, 0.1334 mg/L @ 25 °C (est) |
Cosmetic Information
| CosIng | cosmetic data |
| Cosmetic Uses | skin conditioning |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | emollients, skin conditioning |
| Recommendation for cis-6-hexadecenoic acid usage levels up to | not for fragrance use. |
| Recommendation for cis-6-hexadecenoic acid flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
(Z)-
hexadec-6-enoic acid
hexadecenoic acid
(6Z)-6-
hexadecenoic acid
(Z)-6-
hexadecenoic acid
6-
hexadecenoic acid, (6Z)-
lunac HD
16:1
omega10
sapienic acid
PubMed:
Hexadecenoic Fatty Acid Isomers in Human Blood Lipids and Their Relevance for the Interpretation of Lipidomic Profiles.
PubMed:
Quantification of Phytochemicals from Commercial Spirulina Products and Their Antioxidant Activities.
PubMed:
Palmitic acid (16:0) competes with omega-6 linoleic and omega-3 É-linolenic acids for FADS2 mediated Î6-desaturation.
PubMed:
Protein Analysis of Sapienic Acid-Treated Porphyromonas gingivalis Suggests Differential Regulation of Multiple Metabolic Pathways.
PubMed:
The effect of skin fatty acids on Staphylococcus aureus.
PubMed:
Synthesis of novel lipoamino acid conjugates of sapienic acid and evaluation of their cytotoxicity activities.
PubMed:
Bactericidal activity of the human skin fatty acid cis-6-hexadecanoic acid on Staphylococcus aureus.
PubMed:
Hexadecenoic fatty acid isomers: a chemical biology approach for human plasma biomarker development.
PubMed:
The roles of cutaneous lipids in host defense.
PubMed:
Oral mucosal lipids are antibacterial against Porphyromonas gingivalis, induce ultrastructural damage, and alter bacterial lipid and protein compositions.
PubMed:
Induction of the staphylococcal proteolytic cascade by antimicrobial fatty acids in community acquired methicillin resistant Staphylococcus aureus.
PubMed:
Host- and microbe determinants that may influence the success of S. aureus colonization.
PubMed:
Antibacterial activity of sphingoid bases and fatty acids against Gram-positive and Gram-negative bacteria.
PubMed:
Identification of Î6-monounsaturated fatty acids in human hair and nail samples by gas-chromatography-mass-spectrometry using ionic-liquid coated capillary column.
PubMed:
Chemometric approach for investigating the skin surface lipids (SSLs) composition: influence of geographical localization.
PubMed:
Biosynthesis of unusual moth pheromone components involves two different pathways in the navel orangeworm, Amyelois transitella.
PubMed:
Hyperproduction of sebaceous cis-6-hexadecenoic acid by esterase-reduced mutant of Rhodococcus sp. strain.
PubMed:
Thematic review series: skin lipids. Antimicrobial lipids at the skin surface.
PubMed:
Deficient production of hexadecenoic acid in the skin is associated in part with the vulnerability of atopic dermatitis patients to colonization by Staphylococcus aureus.
PubMed:
Production of isopropyl cis-6-hexadecenoate by regiospecific desaturation of isopropyl palmitate by a double mutant of a Rhodococcus strain.