ilomastat

butanediamide, N4-hydroxy-N1-(1-(1H-indol-3-ylmethyl)-2-(methylamino)-2-oxoethyl)-2-(2-methylpropyl)-, (S-(R*,S*))- galardin (S-(R*,S*))-N(sup 4)- hydroxy-N(sup 1)-(1H-indol-3-ylmethyl)-2-(methylamino)-2-oxoethyl)-2-(2-methylopropyl)butanediamide (R)-N(sup 1)- hydroxy-N-((S)-2-indol-3-yl-1-(methylcarbamoyl)ethyl)-2-isobutylsuccinamide (2R)-N'- hydroxy-N-[(2S)-3-(1H-indol-3-yl)-1-(methylamino)-1-oxopropan-2-yl]-2-(2-methylpropyl)butanediamide PubMed: Association of MMP-8 with obesity, smoking and insulin resistance. PubMed: Selective non-zinc binding MMP-2 inhibitors: Novel benzamide Ilomastat analogs with anti-tumor metastasis. PubMed: ADAMTS13 and 15 are not regulated by the full length and N-terminal domain forms of TIMP-1, -2, -3 and -4. PubMed: Bisphenol A and Related Alkylphenols Exert Nongenomic Estrogenic Actions Through a G Protein-Coupled Estrogen Receptor 1 (Gper)/Epidermal Growth Factor Receptor (Egfr) Pathway to Inhibit Meiotic Maturation of Zebrafish Oocytes. PubMed: Sequential Therapy with Saratin, Bevacizumab and Ilomastat to Prolong Bleb Function following Glaucoma Filtration Surgery in a Rabbit Model. PubMed: Antibody-based exosite inhibitors of ADAMTS-5 (aggrecanase-2). PubMed: Involvement of epidermal growth factor receptors and mitogen-activated protein kinase in progestin-induction of sperm hypermotility in Atlantic croaker through membrane progestin receptor-alpha. PubMed: Reducing tumor growth and angiogenesis using a triple therapy measured with Contrast-enhanced ultrasound (CEUS). PubMed: Matrix metalloproteinases regulate extracellular levels of SDF-1/CXCL12, IL-6 and VEGF in hydrogen peroxide-stimulated human periodontal ligament fibroblasts. PubMed: Near-infrared triple-helical peptide with quenched fluorophores for optical imaging of MMP-2 and MMP-9 proteolytic activity in vivo. PubMed: Mesenchymal to amoeboid transition is associated with stem-like features of melanoma cells. PubMed: Extra-cellular matrix proteins induce matrix metalloproteinase-1 (MMP-1) activity and increase airway smooth muscle contraction in asthma. PubMed: Moderate inhibition of myocardial matrix metalloproteinase-2 by ilomastat is cardioprotective. PubMed: Molecular dynamic simulations of ocular tablet dissolution. PubMed: Proteolysis controls endogenous substance P levels. PubMed: Matrix metalloproteinase inhibition protects CyPD knockout mice independently of RISK/mPTP signalling: a parallel pathway to protection. PubMed: Initial characterization of a dually radiolabeled peptide for simultaneous monitoring of protein targets and enzymatic activity. PubMed: Functional characterization of the Mycobacterium tuberculosis zinc metallopeptidase Zmp1 and identification of potential substrates. PubMed: Characterisation of ilomastat for prolonged ocular drug release. PubMed: Concanavalin-A-induced autophagy biomarkers requires membrane type-1 matrix metalloproteinase intracellular signaling in glioblastoma cells. PubMed: Preparation and in vitro evaluation of an ilomastat microemulsion gel by a self-microemulsifying system. PubMed: Novel Gd(III)-based probes for MR molecular imaging of matrix metalloproteinases. PubMed: Matrix metalloproteinase inhibitor attenuates cochlear lateral wall damage induced by intratympanic instillation of endotoxin. PubMed: Effects of platelet-rich and -poor plasma on the reparative response of gingival fibroblasts. PubMed: Involvement of epidermal growth factor receptor signaling in estrogen inhibition of oocyte maturation mediated through the G protein-coupled estrogen receptor (Gper) in zebrafish (Danio rerio). PubMed: LIM kinase1 modulates function of membrane type matrix metalloproteinase 1: implication in invasion of prostate cancer cells. PubMed: Relative roles of doxycycline and cation chelation in endothelial glycan shedding and adhesion of leukocytes. PubMed: Sulfur mustard-induced pulmonary injury: therapeutic approaches to mitigating toxicity. PubMed: Development of a novel tumor-targeted vascular disrupting agent activated by membrane-type matrix metalloproteinases. PubMed: Role of iNOS and peroxynitrite-matrix metalloproteinase-2 signaling in myocardial late preconditioning in rats. PubMed: Matrix metalloproteinase inhibition enhances the rate of nerve regeneration in vivo by promoting dedifferentiation and mitosis of supporting schwann cells. PubMed: Airway smooth muscle remodels pericellular collagen fibrils: implications for proliferation. PubMed: Anti-inflammatory effects of formoterol and ipratropium bromide against acute cadmium-induced pulmonary inflammation in rats. PubMed: Inhibition of glycan shedding and leukocyte-endothelial adhesion in postcapillary venules by suppression of matrixmetalloprotease activity with doxycycline. PubMed: The role of an MMP inhibitor in the regulation of mechanical tension by Dupuytren's disease fibroblasts. PubMed: Matrix metalloprotease expressions in both reperfusion lung injury and oleic acid lung injury models and the protective effects of ilomastat. PubMed: Use of a three-dimensional cell culture model to study airway smooth muscle-mast cell interactions in airway remodeling. PubMed: Fibrillar collagen clamps lung mesenchymal cells in a nonproliferative and noncontractile phenotype. PubMed: Matrix metalloproteinase inhibition reduces contraction by dupuytren fibroblasts. PubMed: Matrix metalloproteinase inhibitors reduce collagen gel contraction and alpha-smooth muscle actin expression by periodontal ligament cells. PubMed: Evaluation of protease inhibitors and an antioxidant for treatment of sulfur mustard-induced toxic lung injury. PubMed: Protective effect of ilomastat on trinitrobenzenesulfonic acid-induced ulcerative colitis in rats. PubMed: Prostaglandin E2 exerts catabolic effects in osteoarthritis cartilage: evidence for signaling via the EP4 receptor. PubMed: Introduction of the 4-(4-bromophenyl)benzenesulfonyl group to hydrazide analogs of Ilomastat leads to potent gelatinase B (MMP-9) inhibitors with improved selectivity. PubMed: The effect of stress-deprivation and cyclic loading on the TIMP/MMP ratio in tendon cells: an in vitro experimental study. PubMed: CD44-epidermal growth factor receptor interaction mediates hyaluronic acid-promoted cell motility by activating protein kinase C signaling involving Akt, Rac1, Phox, reactive oxygen species, focal adhesion kinase, and MMP-2. PubMed: Dense collagen matrix accelerates osteogenic differentiation and rescues the apoptotic response to MMP inhibition. PubMed: Identification of MMP-12 inhibitors by using biosensor-based screening of a fragment library. PubMed: Bone sialoprotein binding to matrix metalloproteinase-2 alters enzyme inhibition kinetics. PubMed: C-FLIP promotes the motility of cancer cells by activating FAK and ERK, and increasing MMP-9 expression. PubMed: Human laminin-332 degradation by Candida proteinases. PubMed: Simultaneous presence of unsaturation and long alkyl chain at P'1 of Ilomastat confers selectivity for gelatinase A (MMP-2) over gelatinase B (MMP-9) inhibition as shown by molecular modelling studies. PubMed: A sequential, multiple-treatment, targeted approach to reduce wound healing and failure of glaucoma filtration surgery in a rabbit model (an American Ophthalmological Society thesis). PubMed: Matrix metalloproteinase inhibitors prevent a decrease in the mechanical properties of stress-deprived tendons: an in vitro experimental study. PubMed: MT1-MMP down-regulates the glucose 6-phosphate transporter expression in marrow stromal cells: a molecular link between pro-MMP-2 activation, chemotaxis, and cell survival. PubMed: Collagen I and thrombin activate MMP-2 by MMP-14-dependent and -independent pathways: implications for airway smooth muscle migration. PubMed: The role of matrix metalloproteinases in infant traumatic brain injury. PubMed: An inhaled matrix metalloprotease inhibitor prevents cigarette smoke-induced emphysema in the mouse. PubMed: Cooperation of matrix metalloproteinases with the RhoA/Rho kinase and mitogen-activated protein kinase kinase-1/extracellular signal-regulated kinase signaling pathways is required for the sphingosine-1-phosphate-induced mobilization of marrow-derived stromal cells. PubMed: Cell-cell contact activation of fibroblasts increases the expression of matrix metalloproteinases. PubMed: Oxygen radicals and matrix metalloproteinases mediate reperfusion liver injury. PubMed: Metalloproteinase inhibitors, nonantimicrobial chemically modified tetracyclines, and ilomastat block Bacillus anthracis lethal factor activity in viable cells. PubMed: Hyperlipidemia attenuates the infarct size-limiting effect of ischemic preconditioning: role of matrix metalloproteinase-2 inhibition. PubMed: In vitro evaluation of the angiostatic potential of drugs using an endothelialized tissue-engineered connective tissue. PubMed: Prolonged antiscarring effects of ilomastat and MMC after experimental glaucoma filtration surgery. PubMed: Cardiac morphogenesis: matrix metalloproteinase coordination of cellular mechanisms underlying heart tube formation and directionality of looping. PubMed: Inflammatory proteases in chronic otitis externa. PubMed: Poly(ADP-ribose) polymerase-1 promotes microglial activation, proliferation, and matrix metalloproteinase-9-mediated neuron death. PubMed: Evidence for disulfide involvement in the regulation of intramolecular autolytic processing by human adamalysin19/ADAM19. PubMed: Flavonoids promote cell migration in nontumorigenic colon epithelial cells differing in Apc genotype: implications of matrix metalloproteinase activity. PubMed: Activity-based probes for the proteomic profiling of metalloproteases. PubMed: MMP inhibition prevents human lens epithelial cell migration and contraction of the lens capsule. PubMed: A novel strategy for designing specific gelatinase A inhibitors: potential use to control tumor progression. PubMed: Hyaluronan cell surface binding is induced by type I collagen and regulated by caveolae in glioma cells. PubMed: MMPs inhibitors: new succinylhydroxamates with selective inhibition of MMP-2 over MMP-3. PubMed: Galardin (GM 6001), a broad-spectrum matrix metalloproteinase inhibitor, blocks bombesin- and LPA-induced EGF receptor transactivation and DNA synthesis in rat-1 cells. PubMed: Protease inhibitors alpha1-antitrypsin and ilomastat are not ototoxic in the chinchilla. PubMed: Enhancement by neutrophils of collagen degradation by corneal fibroblasts. PubMed: Effects of matrix metalloproteinase inhibitors on bone resorption and orthodontic tooth movement. PubMed: Alpha 1-antitrypsin and ilomastat inhibit inflammatory proteases present in human middle ear effusions. PubMed: Matrix metalloproteinase regulation of sphingosine-1-phosphate-induced angiogenic properties of bone marrow stromal cells. PubMed: Matrix metalloproteinase inhibition modulates fibroblast-mediated matrix contraction and collagen production in vitro. PubMed: Matrix metalloproteinase inhibition modulates postoperative scarring after experimental glaucoma filtration surgery. PubMed: Human corneal epithelial cells require MMP-1 for HGF-mediated migration on collagen I. PubMed: Metalloproteinase shedding of Fas ligand regulates beta-amyloid neurotoxicity. PubMed: Shedding of kidney injury molecule-1, a putative adhesion protein involved in renal regeneration. PubMed: The electrical resistance breakdown assay determines the role of proteinases in tumor cell invasion. PubMed: Membrane-type matrix metalloproteinases mediate curcumin-induced cell migration in non-tumorigenic colon epithelial cells differing in Apc genotype. PubMed: Involvement of matrix metalloproteinases in the adipose conversion of 3T3-L1 preadipocytes. PubMed: Topical synthetic inhibitor of matrix metalloproteinases delays epidermal regeneration of human wounds. PubMed: Mutation analysis of membrane type-1 matrix metalloproteinase (MT1-MMP). The role of the cytoplasmic tail Cys(574), the active site Glu(240), and furin cleavage motifs in oligomerization, processing, and self-proteolysis of MT1-MMP expressed in breast carcinoma cells. PubMed: Matrix metalloproteinases and their inhibitors regulate in vitro ureteric bud branching morphogenesis. PubMed: Determination of matrix metalloproteinase activity using biotinylated gelatin. PubMed: Tissue inhibitor of metalloproteinase-2 stimulates mesenchymal growth and regulates epithelial branching during morphogenesis of the rat metanephros.