costus root oil

saussurea lappa root oil

CAS: 8023-88-9 animal orris

Identification

Namecostus root oil
IUPACsaussurea lappa root oil
CAS Number8023-88-9
FDA UNII2WF6750061
MDL NumberMFCD01771687

Regulatory

FEMA Number2336
FDANo longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm (SATF)8023-88-9 ; COSTUS ROOT, OIL (SAUSSUREA LAPPA CLARKE)
FDA RegulationFDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION

Physical Properties

Appearance pale yellow solid (est)
Food Chemicals Codex Listed No
Soluble in alcohol
Insoluble in water
Stability non-discoloring in most media

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesnot used anymore

Organoleptic Properties

Odor Strength medium
Substantivity 316 hour(s) at 100.00 %
Odor Description
at 100.00 %.
orris green hairy woody unripe melons
Odor sample from Berje Inc.
Taste Description
costus
Fatty metallic like herbal

Safety Information

Preferred SDSView
European informationMost important hazard(s):
Oral/Parenteral Toxicityoral-rat LD50 3400 mg/kg
Dermal Toxicityskin-rabbit LD50 > 5000 mg/kg
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryflavoring agents
IFRA Critical EffectDermal sensitization
Recommendation for costus root oil usage levels up toPROHIBITED: Should not be used as a fragrance ingredient.
baked goods-
beverages(nonalcoholic)-
beverages(alcoholic)-
breakfast cereal-
cheese-
chewing gum-
condiments / relishes-
confectionery froastings-
egg products-
fats / oils-
fish products-
frozen dairy-
fruit ices-
gelatins / puddings-
granulated sugar-
gravies-
hard candy-
imitation dairy-
instant coffee / tea-
jams / jellies-
meat products-
milk products-
nut products-
other grains-
poultry-
processed fruits-
processed vegetables-
reconstituted vegetables-
seasonings / flavors-
snack foods-
soft candy-
soups-
sugar substitutes-
sweet sauces-

CJ Latta & Associates, LLC

Extensive Line

Aromatic Chemicals and Organic Acids.

View All Website (630) 240-8079 chiplatta@msn.com

Excellentia International

Ingredients by Nature

Exceptional quality and excellence in meeting our customers requirements.

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Firmenich Inc.

We Create

We create perfumes and flavors for the World's most desirable brands.

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Fleurchem, Inc.

Have A Flavorful Day

A leading global manufacturer and supplier of ingredients for Flavors, Fragrances, AromaTherapy, Foods, Beverages, Personal Care Products, and other uses.

View All Website 845-341-2100 info@fleurchem.com

Lluch Essence S.L.

A family company dedicated to sales and distribution

Flexibility, availability, price and quality.

View All Website 34 93 379 38 49 web@lluche.com

Moellhausen S.P.A.

THE CHEMISTRY OF EMOTIONS

Innovation and commitment in the name of excellence.

View All Website +39 039.685.6262

Nanda Medicinal Plants Exports

Cultivator & Collector of Himalayan Medicinal Herbs

Company working and exporting under CITES Authority.

View All Website +91 98160 57660 info@saussurea-costus.com

Penta International Corporation

Chemistry innovation

At Penta, our products and services help businesses do business better.

View All Website (973) 740-2300 lisaa@pentamfg.com

Robertet, Inc.

HOME OF NATURE, SEED TO SCENT

HOME OF NATURE – natural ingredients from the source.

View All Website +1.201.337.7100 info@robertetUSA.com

Sigma-Aldrich

Complete Supply Chain

The perfect blend of products and services that bring your creativity to life.

View All Website 800-244-1173 ff@sial.com

Ultra International Limited

Driven by a mutual passion for excellence.

Ultra International is one of the leading company in the Flavors and Fragrance industry.

View All Website 0019143161580 ultra@ultrainternational.com

Vigon International

Passion for Simplicity

Manufacturer and supplier of high quality flavor and fragrance ingredients.

View All Website 570-476-6300 sales@vigon.com

Potential Uses

FR aldehydic FR animal bellodgia cachet FR chypre diffusion FR fern FR floral fur hair my sin FR narcissus FR oriental FR orris FR patchouli oil replacer presence scandal tabu topnotes FR tuberose FR vetiver FL violet vol de nuit FR woody

Natural Occurrence

costus root

Synonyms

aplotaxis lappa root oil aucklandia costus root oil auklandra costus root oil costus oil costus oil 100 costus root oil (saussurea lappa clarke) saussurea costus root oil saussurea lappa root oil spiral flag root oil (saussurea lappa clarke) PubMed: UPLC/MS/MS method for quantification and cytotoxic activity of sesquiterpene lactones isolated from Saussurea lappa. PubMed: Volatile constituents of Saussurea costus roots cultivated in Uttarakhand Himalayas, India. PubMed: Evaluation of anti-resistant activity of Auklandia (Saussurea lappa) root against some human pathogens. PubMed: Aqueous extract of Saussurea lappa root ameliorate oxidative myocardial injury induced by isoproterenol in rats. PubMed: Santamarin, a sesquiterpene lactone isolated from Saussurea lappa, represses LPS-induced inflammatory responses via expression of heme oxygenase-1 in murine macrophage cells. PubMed: Larvicidal activity of medicinal plant extracts and lignan identified in Phryma leptostachya var. asiatica roots against housefly (Musca domestica L.). PubMed: Matrix solid-phase dispersion extraction coupled with HPLC-diode array detection method for the analysis of sesquiterpene lactones in root of Saussurea lappa C.B.Clarke. PubMed: Dehydrocostus lactone prevents mitochondrial dysfunction in osteoblastic MC3T3-E1 cells. PubMed: A new sesquiterpene and other constituents from Saussurea lappa root. PubMed: Antihepatotoxic activity of Saussurea lappa extract on D-galactosamine and lipopolysaccharide-induced hepatitis in mice. PubMed: Apoptosis of DU145 human prostate cancer cells induced by dehydrocostus lactone isolated from the root of Saussurea lappa. PubMed: Authentication of Saussurea lappa, an endangered medicinal material, by ITS DNA and 5S rRNA sequencing. PubMed: Effects of Saussurea lappa roots extract in ethanol on leukocyte phagocytic activity, lymphocyte proliferation and interferon-gamma (IFN-gamma). PubMed: Presence of cholinergic and calcium antagonist constituents in Saussurea lappa explains its use in constipation and spasm. PubMed: Saussurea lappa induces G2-growth arrest and apoptosis in AGS gastric cancer cells. PubMed: Costunolide inhibits interleukin-1beta expression by down-regulation of AP-1 and MAPK activity in LPS-stimulated RAW 264.7 cells. PubMed: Cytotoxic sesquiterpene lactones from the root of Saussurea lappa. PubMed: Germacrenes from fresh costus roots. PubMed: Costunolide induces apoptosis by ROS-mediated mitochondrial permeability transition and cytochrome C release. PubMed: Inhibition of inducible nitric oxide synthesis by the herbal preparation Padma 28 in macrophage cell line. PubMed: Effect of dehydrocostus lactone and costunolide from Saussurea root on the central nervous system in mice. PubMed: Effect of polyols on heat inactivation of Aspergillus niger van Teighem inulinase. PubMed: Active compounds from Saussurea lappa Clarks that suppress hepatitis B virus surface antigen gene expression in human hepatoma cells. PubMed: Saussureamines A, B, C, D, and E, new anti-ulcer principles from Chinese Saussureae Radix. PubMed: Sesquiterpenoids from costum root oil (Saussurea lappa Clarke)