rhododendrol
4-(p-hydroxyphenyl)butan-2-ol
Identification
| Name | rhododendrol |
| IUPAC | 4-(3-hydroxybutyl)phenol |
| CAS Number | 69617-84-1 |
| EINECS | 274-056-1 |
| FDA UNII | 12QWN45UL0 |
| Molecular Formula | C10 H14 O2 |
| Molecular Weight | 166.21998000 |
| MDL Number | MFCD01117650 |
| Nikkaji Number | J318.011E |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Soluble in | water, 1.559e+004 mg/L @ 25 °C (est) |
Cosmetic Information
| CosIng | cosmetic data |
| Cosmetic Uses | skin conditioning |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | cosmetic ingredient for skin conditioning |
| Recommendation for rhododendrol usage levels up to | not for fragrance use. |
Potential Uses
Natural Occurrence
Synonyms
benzenepropanol, 4-hydroxy-alpha-methyl-
4-(3-
hydroxybutyl)phenol
4-(p-
hydroxyphenyl)-2-butanol
4-(p-
hydroxyphenyl)butan-2-ol
raspberry ketone alcohol
PubMed:
Glutathione maintenance is crucial for survival of melanocytes after exposure to rhododendrol.
PubMed:
The effect of rhododendrol inhibition of NF-κB on melanocytes in the presence of tyrosinase.
PubMed:
The spectrophotometrical analysis of rhododendrol-induced leucoderma using a novel multispectral camera.
PubMed:
Biochemical effects of the flavanol-rich lychee fruit extract on the melanin biosynthesis and reactive oxygen species.
PubMed:
Rhododenol and raspberry ketone impair the normal proliferation of melanocytes through reactive oxygen species-dependent activation of GADD45.
PubMed:
NAD(P)H dehydrogenase, quinone 1 (NQO1), protects melanin-producing cells from cytotoxicity of rhododendrol.
PubMed:
[Leukoderma caused by chemicals: mechanisms underlying 4-alkyl/aryl-substituted phenols- and rhododendrol-induced melanocyte loss].
PubMed:
T-Cell Responses to Tyrosinase-Derived Self-Peptides in Patients with Leukoderma Induced by Rhododendrol: Implications for Immunotherapy Targeting Melanoma.
PubMed:
Rhododenol-induced leukoderma in a mouse model mimicking Japanese skin.
PubMed:
Different effects of five depigmentary compounds, rhododendrol, raspberry ketone, monobenzone, rucinol and AP736 on melanogenesis and viability of human epidermal melanocytes.
PubMed:
Rhododendrol glycosides as stereospecific tyrosinase inhibitors.
PubMed:
Effects of rhododendrol and its metabolic products on melanocytic cell growth.
PubMed:
A convenient screening method to differentiate phenolic skin whitening tyrosinase inhibitors from leukoderma-inducing phenols.
PubMed:
Rhododendrol-induced leukoderma accompanied by allergic contact dermatitis caused by a non-rhododendrol skin-lightening agent, 5,5'-dipropylbiphenyl-2,2'-diol.
PubMed:
The mechanism of melanocytes-specific cytotoxicity induced by phenol compounds having a prooxidant effect, relating to the appearance of leukoderma.
PubMed:
Possible involvement of CCR4+ CD8+ T cells and elevated plasma CCL22 and CCL17 in patients with rhododenol-induced leukoderma.
PubMed:
Biochemical, cytological, and immunological mechanisms of rhododendrol-induced leukoderma.
PubMed:
Melanocyte-specific cytotoxic T lymphocytes in patients with rhododendrol-induced leukoderma.
PubMed:
Tyrosinase-catalyzed metabolism of rhododendrol (RD) in B16 melanoma cells: production of RD-pheomelanin and covalent binding with thiol proteins.
PubMed:
4-(4-hydroroxyphenyl)-2-butanol (rhododendrol) activates the autophagy-lysosome pathway in melanocytes: insights into the mechanisms of rhododendrol-induced leukoderma.
PubMed:
An immune pathological and ultrastructural skin analysis for rhododenol-induced leukoderma patients.
PubMed:
[Phenolic compounds from Rhododendron phaeochrysum var. agglutinatum].
PubMed:
Human tyrosinase is able to oxidize both enantiomers of rhododendrol.
PubMed:
Depigmentation caused by application of the active brightening material, rhododendrol, is related to tyrosinase activity at a certain threshold.
PubMed:
Tyrosinase-catalyzed oxidation of rhododendrol produces 2-methylchromane-6,7-dione, the putative ultimate toxic metabolite: implications for melanocyte toxicity.
PubMed:
Rhododendrol, a depigmentation-inducing phenolic compound, exerts melanocyte cytotoxicity via a tyrosinase-dependent mechanism.
PubMed:
Chemical synthesis and tyrosinase inhibitory activity of rhododendrol glycosides.
PubMed:
Rhododendrin, an analgesic/anti-inflammatory arylbutanoid glycoside, from the leaves of Rhododendron aureum.
PubMed:
Osteogenic activity of diphenyl ether-type cyclic diarylheptanoids derived from Acer nikoense.
PubMed:
Melanogenesis inhibitory and free radical scavenging activities of diarylheptanoids and other phenolic compounds from the bark of Acer nikoense.
PubMed:
(+)-rhododendrol and epi-rhododendrin suppress the NO production by activated macrophages in vivo.