rhododendrol

4-(p-hydroxyphenyl)butan-2-ol

CAS: 69617-84-1 C10 H14 O2 MW: 166.21998000

Identification

Namerhododendrol
IUPAC4-(3-hydroxybutyl)phenol
CAS Number69617-84-1
EINECS274-056-1
FDA UNII12QWN45UL0
Molecular FormulaC10 H14 O2
Molecular Weight166.21998000
MDL NumberMFCD01117650
Nikkaji NumberJ318.011E

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Soluble in water, 1.559e+004 mg/L @ 25 °C (est)

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesskin conditioning

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorycosmetic ingredient for skin conditioning
Recommendation for rhododendrol usage levels up tonot for fragrance use.

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Potential Uses

None Found

Natural Occurrence

found in nature

Synonyms

benzenepropanol, 4-hydroxy-alpha-methyl- 4-(3- hydroxybutyl)phenol 4-(p- hydroxyphenyl)-2-butanol 4-(p- hydroxyphenyl)butan-2-ol raspberry ketone alcohol PubMed: Glutathione maintenance is crucial for survival of melanocytes after exposure to rhododendrol. PubMed: The effect of rhododendrol inhibition of NF-κB on melanocytes in the presence of tyrosinase. PubMed: The spectrophotometrical analysis of rhododendrol-induced leucoderma using a novel multispectral camera. PubMed: Biochemical effects of the flavanol-rich lychee fruit extract on the melanin biosynthesis and reactive oxygen species. PubMed: Rhododenol and raspberry ketone impair the normal proliferation of melanocytes through reactive oxygen species-dependent activation of GADD45. PubMed: NAD(P)H dehydrogenase, quinone 1 (NQO1), protects melanin-producing cells from cytotoxicity of rhododendrol. PubMed: [Leukoderma caused by chemicals: mechanisms underlying 4-alkyl/aryl-substituted phenols- and rhododendrol-induced melanocyte loss]. PubMed: T-Cell Responses to Tyrosinase-Derived Self-Peptides in Patients with Leukoderma Induced by Rhododendrol: Implications for Immunotherapy Targeting Melanoma. PubMed: Rhododenol-induced leukoderma in a mouse model mimicking Japanese skin. PubMed: Different effects of five depigmentary compounds, rhododendrol, raspberry ketone, monobenzone, rucinol and AP736 on melanogenesis and viability of human epidermal melanocytes. PubMed: Rhododendrol glycosides as stereospecific tyrosinase inhibitors. PubMed: Effects of rhododendrol and its metabolic products on melanocytic cell growth. PubMed: A convenient screening method to differentiate phenolic skin whitening tyrosinase inhibitors from leukoderma-inducing phenols. PubMed: Rhododendrol-induced leukoderma accompanied by allergic contact dermatitis caused by a non-rhododendrol skin-lightening agent, 5,5'-dipropylbiphenyl-2,2'-diol. PubMed: The mechanism of melanocytes-specific cytotoxicity induced by phenol compounds having a prooxidant effect, relating to the appearance of leukoderma. PubMed: Possible involvement of CCR4+ CD8+ T cells and elevated plasma CCL22 and CCL17 in patients with rhododenol-induced leukoderma. PubMed: Biochemical, cytological, and immunological mechanisms of rhododendrol-induced leukoderma. PubMed: Melanocyte-specific cytotoxic T lymphocytes in patients with rhododendrol-induced leukoderma. PubMed: Tyrosinase-catalyzed metabolism of rhododendrol (RD) in B16 melanoma cells: production of RD-pheomelanin and covalent binding with thiol proteins. PubMed: 4-(4-hydroroxyphenyl)-2-butanol (rhododendrol) activates the autophagy-lysosome pathway in melanocytes: insights into the mechanisms of rhododendrol-induced leukoderma. PubMed: An immune pathological and ultrastructural skin analysis for rhododenol-induced leukoderma patients. PubMed: [Phenolic compounds from Rhododendron phaeochrysum var. agglutinatum]. PubMed: Human tyrosinase is able to oxidize both enantiomers of rhododendrol. PubMed: Depigmentation caused by application of the active brightening material, rhododendrol, is related to tyrosinase activity at a certain threshold. PubMed: Tyrosinase-catalyzed oxidation of rhododendrol produces 2-methylchromane-6,7-dione, the putative ultimate toxic metabolite: implications for melanocyte toxicity. PubMed: Rhododendrol, a depigmentation-inducing phenolic compound, exerts melanocyte cytotoxicity via a tyrosinase-dependent mechanism. PubMed: Chemical synthesis and tyrosinase inhibitory activity of rhododendrol glycosides. PubMed: Rhododendrin, an analgesic/anti-inflammatory arylbutanoid glycoside, from the leaves of Rhododendron aureum. PubMed: Osteogenic activity of diphenyl ether-type cyclic diarylheptanoids derived from Acer nikoense. PubMed: Melanogenesis inhibitory and free radical scavenging activities of diarylheptanoids and other phenolic compounds from the bark of Acer nikoense. PubMed: (+)-rhododendrol and epi-rhododendrin suppress the NO production by activated macrophages in vivo.