omega-pentadecalactone

exaltolide (Firmenich)

CAS: 106-02-5 C15 H28 O2 MW: 240.38656000 musk vanilla

Identification

Nameomega-pentadecalactone
IUPAC16-oxacyclohexadecan-1-one
CAS Number106-02-5
EINECS203-354-6
FDA UNIIOK17S3S98K
Molecular FormulaC15 H28 O2
Molecular Weight240.38656000
MDL NumberMFCD00039667
Nikkaji NumberJ4.546B
Beilstein0143710
CoE Number181

Regulatory

JECFA Food Flavoring239 omega-pentadecalactone
DG SANTE Food Flavourings10.004 pentadecano-1,15-lactone
FEMA Number2840
FDANo longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm (SATF)106-02-5 ; OMEGA-PENTADECALACTONE
FDA RegulationFDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION

Physical Properties

Appearance colorless solid (est)
Assay 98.00 to 100.00
Food Chemicals Codex Listed No
Melting Point 34.00 to 38.00 °C. @ 760.00 mm Hg
Boiling Point 137.00 °C. @ 2.00 mm Hg
Congealing Point 36.00 °C.
Flash Point > 220.00 °F. TCC ( > 104.44 °C. )
logP (o/w) 6.100
Shelf Life 36.00 month(s) or longer if stored properly.
Storage store in cool, dry place in tightly sealed containers, protected from heat and light.
Soluble in alcohol
Stability alcoholic solution: 0.5 - 5%

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesfragrance

Organoleptic Properties

Odor Strength high ,
Substantivity 400 hour(s) at 10.00 % in dipropylene glycol
Odor Description
at 10.00 % in dipropylene glycol.
Tobacco, coumarin, heliotropine, powdery, licorice and brown
This quality of EXALTOLIDE® is an extremely fine and elegant musk but more cost effective. EXALTOLIDE® TOTAL is one of the finest synthetic musk notes that possesses a very natural
An extremely fine and elegant musk. EXALTOLIDE® is one of the finest synthetic musk notes that possesses a very natural quality
warm, elegant, cosmetic and caring balsamic musk type with floral elements
fine, elegant macrocyclic musk lactone note with a high impact and animalic, balsamic notes
powerful musk, herbal note (angelica root- like)
An elegant, pleasant sweet animal musky note
sweet powdery musk woody powerful musk
sweet, musky-animal, rich, herbal
Odor sample from Firmenich Inc.
Taste Description
at 75.00 ppm.
sweet powdery soapy
Musk, Perfumistic, Soapy
sweet, soap, musk-pear like
musk

Safety Information

Preferred SDSView
European informationMost important hazard(s):
Human Experience10 % solution: no irritation or sensitization.
Oral/Parenteral Toxicityoral-rat LD50 > 5000 mg/kg
Dermal Toxicityskin-rabbit LD50 > 5000 mg/kg
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryflavor and fragrance agents
RIFM Fragrance Material Safety AssessmentSearch
IFRA Critical EffectDermal sensitization and systemic toxicity
IFRA RESTRICTION LIMITS IN THE FINISHED PRODUCT (%)Category 1: Products applied to the lips
NotesIFRA FLAVOR REQUIREMENTS:
Maximised Survey-derived Daily Intakes (MSDI-EU)73.00 (μg/capita/day)
baked goods-
beverages(nonalcoholic)-
beverages(alcoholic)-
breakfast cereal-
cheese-
chewing gum-
condiments / relishes-
confectionery froastings-
egg products-
fats / oils-
fish products-
frozen dairy-
fruit ices-
gelatins / puddings-
granulated sugar-
gravies-
hard candy-
imitation dairy-
instant coffee / tea-
jams / jellies-
meat products-
milk products-
nut products-
other grains-
poultry-
processed fruits-
processed vegetables-
reconstituted vegetables-
seasonings / flavors-
snack foods-
soft candy-
soups-
sugar substitutes-
sweet sauces-

Associate Allied Chemicals

Quality, Service and Values

Our aim is to become a reliable one-stop shop for our customers.

View All Website +91 22 2419 8800 aacipl@aacipl.com

Augustus Oils Ltd

The Premier Supplier

Augustus Oils Ltd, in harmony with nature - to present it at its best...

View All Website +44 (0)1420 590555 essentials@augustus-oils.ltd.uk

Azelis UK Ltd.

Chemical Distribution

Azelis is a leading global distributor of speciality chemicals.

View All Website +44 1858 545 837 fi@azelis.co.uk

Berje Inc.

Where the world comes to its senses

Where the world comes to its senses - Berjé is a global distributor of Essential Oils and Aromatic Chemicals.

View All Website 973-748-8980 tlauzurica@berjeinc.com

BOC Sciences

Best of Chemicals Supplier

Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecul...

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Charkit Chemical Corporation

The Specialty Chemical Specialists

Explore this website to discover the products and services that Charkit provides for your industry and please contact us directly to find out how we can be of service to you.

View All Website 203-299-3220 sales@charkit.com

Firmenich Inc.

We Create

We create perfumes and flavors for the World's most desirable brands.

View All Website +1 609 452 1000 Frederick.Keifer@firmenich.com

Indukern, S.A. F&F Ingredients Division

Commitment to quality

Idukern F&F Ingredients is your partner for the fragrance and flavor ingredients.

View All Website +34 93 506 91 00 info@indukern.es

Lluch Essence S.L.

A family company dedicated to sales and distribution

Flexibility, availability, price and quality.

View All Website 34 93 379 38 49 web@lluche.com

M&U International LLC

Steady supply & demand

Meeting customers increasing demands at home as well as abroad.

View All Website 908-359-9000 sales@mu-intel.com

Moellhausen S.P.A.

THE CHEMISTRY OF EMOTIONS

Innovation and commitment in the name of excellence.

View All Website +39 039.685.6262

Pell Wall Perfumes

Hand-made fragrances

Pell Wall maintains a broad palette of ingredients & in order to keep stocks fresh & the options wide we also sell from our own stock.

View All Website +44 (0) 20 3745 0887 https://pellwall.com/contact-us/

Penta International Corporation

Chemistry innovation

At Penta, our products and services help businesses do business better.

View All Website (973) 740-2300 lisaa@pentamfg.com

PerfumersWorld Ltd.

feeeel... the smell!

The one-stop resource for the creative perfumer.

View All Website +66(0)2-99-800-80 pwenquiries@perfumersworld.com

Sigma-Aldrich

Complete Supply Chain

The perfect blend of products and services that bring your creativity to life.

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Soda Aromatic Co., Ltd.

Depth of Experience

We guarantees product safety and quality.

View All Website +81-3-5645-7347 aromachemicals@soda.toray.co.jp

SRS Aromatics Ltd

For over 25 years

Bringing flavour and fragrance into your world.

View All Website +44 (0) 1284 704076 info@srsaromatics.co.uk

Symrise AG

Always Insiring More

Symrise aroma molecules & cosmetic ingredients for unique and innovative fragrances, flavors and cosmetics.

View All Website +49 5531 90 0 scentandcare@symrise.com

Synerzine, Inc.

Innovation. Customization. Aroma Ingredients.

Synerzine is a leading supplier of flavor and fragrance ingredients.

View All Website (404) 524-6744 info@synerzine.com

TCI AMERICA

Moving Your Chemistry Forward

We continuously strive to advance our technology.

View All Website 1-800-423-8616 Sales-US@TCIchemicals.com;

The John D. Walsh Company, Inc

Suppliers Since 1942

Supplying the fragrance and flavor industry with high quality products.

View All Website 973-962-1400 info@johndwalsh.com

The Lermond Company

Your Sourcing Resource

The Lermond family has been sourcing raw materials for the flavor and fragrance industry for nearly 7 decades.

View All Website 201-896-3300 info@lermond.com

R C Treatt and Co Ltd

Innovative ingredient solutions

World-leading innovative ingredient solutions provider for the flavour, fragrance and FMCG industries.

View All Website +1 863 668 9500 enquiries@treatt.com

Qingdao Free Trade Zone United International Co Ltd

Quality Products

A partner in your supply chain solution.

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Ernesto Ventós S.A.

Leaders in essence

We employ our five senses to do our job well.

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Vigon International

Passion for Simplicity

Manufacturer and supplier of high quality flavor and fragrance ingredients.

View All Website 570-476-6300 sales@vigon.com

Potential Uses

FR abronia FR acacia FR amber FR ambergris FR ambrette oil replacer FL/FR angelica FR animal FR crabapple FR autumn FR azalea FR balsam FR bark FR bayberry FR beeswax absolute replacer FR blackberry FR blueberry FR boronia FR bouquet FR boysenberry cabochard FR cabreuva wood FR cassia blossom FR cedar FR cedar forest FR champaca chanel #5 FR cherry blossom FL chocolate cacao FR chypre FL/FR cistus FR citrus FR civet clean FR clover FR colonia FR country meadow FR cyclamen FR daffodil FR daphne FR dogwood dusty fantasy blends FR fern FR fig FR fir balsam FR fir needle oil replacer fixer FR floral FR flouve FR flouve blossom FR foliage FR frangipani plumeria FR freesia FR genet FR ginger white ginger FR gooseberry FL/FR guaiacwood FR guava FR gurjun balsam FR hawthorn FR hay new mown hay FR heather FR herbal FR hibiscus FR hinoki oil replacer FR hollyberry FR huckleberry FR hugonia FL/FR immortelle FR incense joy FR kewda FR kiwi FR kiwi blossom FR kumquat FR labdanum FR lavender FR leather FR lemon FL licorice red licorice FR lily FR lily of the valley FR lime FR loganberry FR lotus FR lychee FR mango FR millefleurs FR mimosa FR moss FR mulberry FR musk FR oakwood FR ocean sea FR orange FR orange blossom FR orchid FR oriental FR pansy FR papaya FR passion blossom FR passion fruit FR patchouli FR petunia FR phlox FR pine FR pine forest FR plum FR pomegranate FR poppy FR powder FR privet blossom FR rain FR raspberry FR reseda FR rhubarb FR rose FR rose d'orient FR rose red rose FR rose tea rose FR rose white rose rose wild rose FR sandalwood FR soapy sandalwood moss FR spearmint FR spice FR spring rain FR stephanotis FR sweet grass tabu FL tea timber FR tobacco FR toffee FR tonka bean FR tulip FR vanilla FR verbena FR wintergreen FR wisteria FR woodruff FR woody wool

Natural Occurrence

angelica root oil angelica root oil @ 0.85% Data angelica seed oil CO2 extract @ 7.70% Data

Synonyms

15- angelica lactone cyclo penta decanolide 16-oxa cyclohexadecan-1-one oxa cyclohexadecan-2-one 1-oxa-2- cyclohexadecanone exaltex exaltolide (Firmenich) hexaltolide 15- hydroxypentadecanoic acid e-lactone 15- hydroxypentadecanoic acid lactone 15- hydroxypentadecanoic acid omega-lactone 15- hydroxypentadecanoic acid, lactone macrolide (Symrise) macrolide non-FEMA macrolide supra (Symrise) muscolactone muskalactone muskolactone 2- pentadecalone pentadecan-15-olide pentadecane-15-olide pentadecano-1,15-lactone 15- pentadecanolactone pentadecanolid 1,15- pentadecanolide 15- pentadecanolide pentalide (Bedoukian) pentalide (cyclopentadecanolide) 14-oxy tetradecane carbonic acid lactone thibetolide Google Patents: Preparation of cyclopentadecanolide PubMed: Exploring the Solid State Properties of Enzymatic Poly(amine-co-ester) Terpolymers to Expand their Applications in Gene Transfection. Google Patents: Process for the preparation of cyclopentadecanolide PubMed: Method for preparation, programming, and characterization of miniaturized particulate shape-memory polymer matrices. PubMed: Micelles of enzymatically synthesized PEG-poly(amine-co-ester) block copolymers as pH-responsive nanocarriers for docetaxel delivery. PubMed: Evaluation of PEG and mPEG-co-(PGA-co-PDL) microparticles loaded with sodium diclofenac. PubMed: Characterization of CpdC, a large-ring lactone-hydrolyzing enzyme from Pseudomonas sp. strain HI-70, and its use as a fusion tag facilitating overproduction of proteins in Escherichia coli. PubMed: Multifunctional hybrid nanocomposites with magnetically controlled reversible shape-memory effect. PubMed: Evaluation of biodegradable polyester-co-lactone microparticles for protein delivery. PubMed: Treatment of lung cancer using nanoparticle drug delivery systems. PubMed: Dry powder inhalation of macromolecules using novel PEG-co-polyester microparticle carriers. PubMed: Upscaling the synthesis of biodegradable multiblock copolymers capable of a shape-memory effect. PubMed: Fragrance material review on ω-pentadecalactone. PubMed: Biodegradation, biocompatibility, and drug delivery in poly(ω-pentadecalactone-co-p-dioxanone) copolyesters. PubMed: Poly(glycerol adipate-co-ω-pentadecalactone) spray-dried microparticles as sustained release carriers for pulmonary delivery. PubMed: Lipase-catalyzed copolymerization of dialkyl carbonate with 1,4-butanediol and ω-pentadecalactone: synthesis of poly(ω-pentadecalactone-co-butylene-co-carbonate). PubMed: One-way and reversible dual-shape effect of polymer networks based on polypentadecalactone segments. PubMed: Electrospun scaffolds of a polyhydroxyalkanoate consisting of omega-hydroxylpentadecanoate repeat units: fabrication and in vitro biocompatibility studies. PubMed: Synthesis of omega-hydroxy carboxylic acids and alpha,omega-dimethyl ketones using alpha,omega-diols as alkylating agents. PubMed: Preparation and evaluation of microspheres prepared from novel polyester-ibuprofen conjugates blended with non-conjugated ibuprofen. PubMed: Poly(omega-pentadecalactone-co-butylene-co-succinate) nanoparticles as biodegradable carriers for camptothecin delivery. PubMed: Scaffold for tissue engineering fabricated by non-isothermal supercritical carbon dioxide foaming of a highly crystalline polyester. PubMed: Lipase-catalyzed synthesis of aliphatic polyesters via copolymerization of lactone, dialkyl diester, and diol. PubMed: Synthesis and evaluation of novel polyester-ibuprofen conjugates for modified drug release. PubMed: New oxa-bridged macrocycles. PubMed: Encapsulation and release of alpha-chymotrypsin from poly(glycerol adipate-co-omega-pentadecalactone) microparticles. PubMed: Lipase catalyzed HEMA initiated ring-opening polymerization: in situ formation of mixed polyester methacrylates by transesterification. PubMed: Humicola insolens cutinase-catalyzed lactone ring-opening polymerizations: kinetic and mechanistic studies. PubMed: Lipase-catalyzed copolymerization of omega-pentadecalactone with p-dioxanone and characterization of copolymer thermal and crystalline properties. PubMed: Enzymatic synthesis and evaluation of new novel omega-pentadecalactone polymers for the production of biodegradable microspheres. PubMed: [Analysis of omega-pentadecalactone by thin-layer chromatography]. PubMed: Cocrystallization of random copolymers of omega-pentadecalactone and epsilon-caprolactone synthesized by lipase catalysis. PubMed: Human olfactory contrast changes during the menstrual cycle. PubMed: Macrocyclic musk compounds--an absence of genotoxicity in the Ames test and the in vivo Micronucleus assay. PubMed: Estrogenic activity of musk fragrances detected by the E-screen assay using human mcf-7 cells.