2-methyl thiazolidine
thiazolidine, 2-methyl-
Identification
| Name | 2-methyl thiazolidine |
| IUPAC | 2-methyl-1,3-thiazolidine |
| CAS Number | 24050-16-6 |
| FDA UNII | 938P672IFL |
| Molecular Formula | C4 H9 N S |
| Molecular Weight | 103.18773000 |
| MDL Number | MFCD00053110 |
| Nikkaji Number | J48.807K |
| Beilstein | 0102519 |
Regulatory
Physical Properties
| Appearance | colorless clear liquid (est) |
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Specific Gravity | 1.51900 to 1.52500 @ 25.00 °C. |
| Pounds per Gallon - (est). | 12.640 to 12.690 |
| Refractive Index | 1.52200 to 1.52800 @ 20.00 °C. |
| Boiling Point | 160.00 °C. @ 760.00 mm Hg |
| Vapor Pressure | 1.608000 mmHg @ 25.00 °C. (est) |
| Flash Point | 132.00 °F. TCC ( 55.56 °C. ) |
| logP (o/w) | -1.189 (est) |
| Soluble in | alcohol |
| Insoluble in | water |
Organoleptic Properties
| Odor Description | at 0.01 % in propylene glycol. |
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | intraperitoneal-mouse LD50 250 mg/kg |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | flavoring agents |
| Recommendation for 2-methyl thiazolidine usage levels up to | not for fragrance use. |
| Maximised Survey-derived Daily Intakes (MSDI-EU) | 0.024 (μg/capita/day) |
| Modified Theoretical Added Maximum Daily Intake (mTAMDI) | 160 (μg/person/day) |
| Threshold of Concern | 540 (μg/person/day) |
| Structure Class | II |
| Dairy products, excluding products of category 02.0 (01.0) | 0.40000 |
| Fats and oils, and fat emulsions (type water-in-oil) (02.0) | 0.20000 |
| Edible ices, including sherbet and sorbet (03.0) | 0.40000 |
| Processed fruit (04.1) | 0.30000 |
| Processed vegetables (incl. mushrooms & fungi, roots & tubers, pulses and legumes), and nuts & seeds (04.2) | - |
| Confectionery (05.0) | 0.40000 |
| Chewing gum (05.3) | - |
| Cereals and cereal products, incl. flours & starches from roots & tubers, pulses & legumes, excluding bakery (06.0) | 0.20000 |
| Bakery wares (07.0) | 0.40000 |
| Meat and meat products, including poultry and game (08.0) | 0.10000 |
| Fish and fish products, including molluscs, crustaceans and echinoderms (MCE) (09.0) | 0.10000 |
| Eggs and egg products (10.0) | - |
| Sweeteners, including honey (11.0) | - |
| Salts, spices, soups, sauces, salads, protein products, etc. (12.0) | 0.20000 |
| Foodstuffs intended for particular nutritional uses (13.0) | 0.40000 |
| Non-alcoholic ("soft") beverages, excl. dairy products (14.1) | 0.20000 |
| Alcoholic beverages, incl. alcohol-free and low-alcoholic counterparts (14.2) | 0.40000 |
| Ready-to-eat savouries (15.0) | 1.00000 |
| Composite foods (e.g. casseroles, meat pies, mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0) | 0.20000 |
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Potential Uses
Natural Occurrence
Synonyms
2-
methyl-1,3-thiazolidine
2-
methylthiazolidine
thiazolidine, 2-methyl-
PubMed:
The cysteine reaction with diacetyl under wine-like conditions: proposed mechanisms for mixed origins of 2-methylthiazole, 2-methyl-3-thiazoline, 2-methylthiazolidine, and 2,4,5-trimethyloxazole.
PubMed:
Acetaldehyde removal from indoor air through chemical absorption using L-cysteine.
PubMed:
Formulation and in-vivo evaluation of L-cysteine chewing gums for binding carcinogenic acetaldehyde in the saliva during smoking.
PubMed:
Synthesis of chiral pyrrolo[1,2-c]thiazoles via intramolecular dipolar cycloaddition of münchnones: an interesting rearrangement to pyrrolo[1,2-c]thiazines.
PubMed:
Formation of malonaldehyde and acetaldehyde from the oxidation of 2'-deoxyribonucleosides.
PubMed:
Quantitative analysis of acetaldehyde in whole blood from human and various animals by gas chromatography.
PubMed:
Prevention of naphthalene-induced cataract and hepatic glutathione loss by the L-cysteine prodrugs, MTCA and PTCA.
PubMed:
Selective modulation of non-protein sulfhydryl levels in Ehrlich ascites tumor bearing mice.
PubMed:
2-Methylthiazolidine and 4-ethylguaiacol, male sex pheromone components of the cockroachNauphoeta cinerea (dictyoptera, blaberidae): A reinvestigation.
PubMed:
Failure of glutathione and cysteine prodrugs to block the chlorpropamide-induced inhibition of aldehyde dehydrogenase in vivo.
PubMed:
Etiological research on gastric cancer and its precursor lesions in Shandong, China.
PubMed:
Seducin, male sex pheromone of the cockroachNauphoeta cinerea: Isolation, identification, and bioassay.
PubMed:
Effects of three cysteine pro-drugs on bleomycin-induced lung fibrosis in hamsters.
PubMed:
Influence of cysteine and nitrate on the endogenous formation of N-nitrosamino acids.
PubMed:
Urinary excretion of N-nitrosamino acids and nitrate by inhabitants in high- and low-risk areas for stomach cancer in northern Japan.
PubMed:
Effect of cigarette smoking and dietary factors on the amount of N-nitrosothiazolidine 4-carboxylic acid and N-nitroso-2-methyl-thiazolidine 4-carboxylic acid in human urine.
PubMed:
Roles of cysteine as both precursor of thiazolidine 4-carboxylic acids found in human urine and possible inhibitor of endogenous N-nitrosation.
PubMed:
Effects of cysteine pro-drugs on acetaminophen-induced hepatotoxicity.
PubMed:
Increased loss and decreased synthesis of hepatic glutathione after acute ethanol administration. Turnover studies.
PubMed:
Occurrence in human urine of new sulphur-containing N-nitrosamino acids N-nitrosothiazolidine 4-carboxylic acid and its 2-methyl derivative, and their formation.
PubMed:
Urinary excretion products after the administration of 14C-acetaldehyde to rats.
PubMed:
Prodrugs of L-cysteine as liver-protective agents. 2(RS)-Methylthiazolidine-4(R)-carboxylic acid, a latent cysteine.