2-methyl-2-thiazoline

2-thiazoline, 2-methyl-

CAS: 2346-00-1 C4 H7 N S MW: 101.17179000 sulfurous

Identification

Name2-methyl-2-thiazoline
IUPAC2-methyl-4,5-dihydro-1,3-thiazole
CAS Number2346-00-1
EINECS219-071-6
FDA UNII8Z6UA8V7WN
Molecular FormulaC4 H7 N S
Molecular Weight101.17179000
MDL NumberMFCD00005314
Nikkaji NumberJ37.314A
Beilstein0104274

Regulatory

DG SANTE Food Flavourings15.086 2-methyl-2-thiazoline

Physical Properties

Appearance pale yellow liquid to solid (est)
Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Melting Point 62.00 °C. @ 760.00 mm Hg
Boiling Point 144.00 °C. @ 760.00 mm Hg
Vapor Pressure 6.250000 mmHg @ 25.00 °C. (est)
Vapor Density 3.48 ( Air = 1 )
Flash Point 99.00 °F. TCC ( 37.22 °C. )
logP (o/w) 0.968 (est)
Soluble in alcohol
Insoluble in water

Organoleptic Properties

Odor Description at 0.10 % in propylene glycol.

Safety Information

Preferred SDSView
European informationMost important hazard(s):
Oral/Parenteral Toxicityintraperitoneal-mouse LD50 600 mg/kg
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryflavoring agents
Recommendation for 2-methyl-2-thiazoline usage levels up tonot for fragrance use.
Maximised Survey-derived Daily Intakes (MSDI-EU)0.012 (μg/capita/day)
Modified Theoretical Added Maximum Daily Intake (mTAMDI)160 (μg/person/day)
Threshold of Concern540 (μg/person/day)
Structure ClassII
Dairy products, excluding products of category 02.0 (01.0)0.40000
Fats and oils, and fat emulsions (type water-in-oil) (02.0)0.20000
Edible ices, including sherbet and sorbet (03.0)0.40000
Processed fruit (04.1)0.30000
Processed vegetables (incl. mushrooms & fungi, roots & tubers, pulses and legumes), and nuts & seeds (04.2)-
Confectionery (05.0)0.40000
Chewing gum (05.3)-
Cereals and cereal products, incl. flours & starches from roots & tubers, pulses & legumes, excluding bakery (06.0)0.20000
Bakery wares (07.0)0.40000
Meat and meat products, including poultry and game (08.0)0.10000
Fish and fish products, including molluscs, crustaceans and echinoderms (MCE) (09.0)0.10000
Eggs and egg products (10.0)-
Sweeteners, including honey (11.0)-
Salts, spices, soups, sauces, salads, protein products, etc. (12.0)0.20000
Foodstuffs intended for particular nutritional uses (13.0)0.40000
Non-alcoholic ("soft") beverages, excl. dairy products (14.1)0.20000
Alcoholic beverages, incl. alcohol-free and low-alcoholic counterparts (14.2)0.40000
Ready-to-eat savouries (15.0)1.00000
Composite foods (e.g. casseroles, meat pies, mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0)0.20000

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Robinson Brothers Limited

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R C Treatt and Co Ltd

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Potential Uses

None Found

Natural Occurrence

beef cooked beef PMC clam PMC tomato juice

Synonyms

4,5- dihydro-2-methyl thiazole 4,5- dihydro-2-methylthiazole 2- methyl-1,3-thiazoline methyl-2-thiazoline 2- methyl-4,5-dihydro-1,3-thiazole thiazole, 4,5-dihydro-2-methyl- 2- thiazoline, 2-methyl- PubMed: Formation of P-C bonds under unexpectedly mild conditions. Phosphoryl migration and metal coordination of diphenylphosphinomethyl-oxazolines and -thiazolines. PubMed: Effect of pH on the Maillard reaction of [13C5]xylose, cysteine, and thiamin. PubMed: Future chelation monotherapy and combination therapy strategies in thalassemia and other conditions. comparison of deferiprone, deferoxamine, ICL670, GT56-252, L1NAll and starch deferoxamine polymers. PubMed: A pyrazolyl-thiazole derivative causes antinociception in mice. PubMed: Advances in iron overload therapies. prospects for effective use of deferiprone (L1), deferoxamine, the new experimental chelators ICL670, GT56-252, L1NA11 and their combinations. PubMed: Hexa-mu-chloro-mu4-oxo-tetrakis[(4,5-dihydro-2-methyl-1,2-thiazole-kappaN)copper(II)]. PubMed: Effects of C-4 stereochemistry and C-4' hydroxylation on the iron clearing efficiency and toxicity of desferrithiocin analogues. PubMed: Site-specific dephosphorylation of tau of apolipoprotein E-deficient and control mice by M1 muscarinic agonist treatment. PubMed: M1 muscarinic agonist treatment reverses cognitive and cholinergic impairments of apolipoprotein E-deficient mice. PubMed: N-nitroso compounds and man: sources of exposure, endogenous formation and occurrence in body fluids. PubMed: [Nasal chemoreception in utero: preliminary experiences in fetal sheep]. PubMed: [Information from the Soviet Toxicology Center].