sialyllactose
N-acetylneuraminoyllactose
Identification
| Name | sialyllactose |
| CAS Number | 35890-38-1 |
| FDA UNII | 3J7TAL60G3 |
| Molecular Formula | C23 H39 N O19 |
| Molecular Weight | 633.55563000 |
| MDL Number | MFCD00166999 |
| Nikkaji Number | J603.805K |
| Beilstein | 0075357 |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Soluble in | water, 1e+006 mg/L @ 25 °C (est) |
Cosmetic Information
| CosIng | cosmetic data |
| Cosmetic Uses | skin conditioning |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | cosmetic ingredient for skin conditioning |
| Recommendation for sialyllactose usage levels up to | not for fragrance use. |
| Recommendation for sialyllactose flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
N-
acetylneuraminoyllactose
D-
glucose, O-(N-acetyl-alpha-neuraminosyl)-(2-3)-O-beta-D-galactopyranosyl-(1-4)-
3-
sialyllactose
PubMed:
3'-Sialyllactose protects against osteoarthritic development by facilitating cartilage homeostasis.
PubMed:
Human milk oligosaccharide consumption by probiotic and human-associated bifidobacteria and lactobacilli.
PubMed:
Production of human milk oligosaccharides by enzymatic and whole-cell microbial biotransformations.
PubMed:
Dietary Human Milk Oligosaccharides but Not Prebiotic Oligosaccharides Increase Circulating Natural Killer Cell and Mesenteric Lymph Node Memory T Cell Populations in Noninfected and Rotavirus-Infected Neonatal Piglets.
PubMed:
Growth and Morbidity of Gambian Infants are Influenced by Maternal Milk Oligosaccharides and Infant Gut Microbiota.
PubMed:
Fucosyllactose and L-fucose utilization of infant Bifidobacterium longum and Bifidobacterium kashiwanohense.
PubMed:
Cell-Free Spent Media Obtained from Bifidobacterium bifidum and Bifidobacterium crudilactis Grown in Media Supplemented with 3'-Sialyllactose Modulate Virulence Gene Expression in Escherichia coli O157:H7 and Salmonella Typhimurium.
PubMed:
Structures of the Streptococcus sanguinis SrpA Binding Region with Human Sialoglycans Suggest Features of the Physiological Ligand.
PubMed:
Porcine Milk Oligosaccharides and Sialic Acid Concentrations Vary Throughout Lactation.
PubMed:
Characterization of porcine milk oligosaccharides during early lactation and their relation to the fecal microbiome.
PubMed:
It All Starts with a Sandwich: Identification of Sialidases with Trans-Glycosylation Activity.
PubMed:
Temporal Change of the Content of 10 Oligosaccharides in the Milk of Chinese Urban Mothers.
PubMed:
NMR analysis on the sialic acid-binding mechanism of an R-type lectin mutant by natural evolution-mimicry.
PubMed:
Galactooligosaccharide and Sialyllactose Content in Commercial Lactose Powders from Goat and Cow Milk.
PubMed:
Gut microbiota analysis reveals a marked shift to bifidobacteria by a starter infant formula containing a synbiotic of bovine milk-derived oligosaccharides and Bifidobacterium animalis subsp. lactisâ
CNCM I-3446.
PubMed:
Oligosaccharides in Urine, Blood, and Feces of Piglets Fed Milk Replacer Containing Galacto-oligosaccharides.
PubMed:
Short communication: Quantification of carbohydrates in whey permeate products using high-performance anion-exchange chromatography with pulsed amperometric detection.
PubMed:
Comparative transcriptomics reveals key differences in the response to milk oligosaccharides of infant gut-associated bifidobacteria.
PubMed:
Chemical characterization of milk oligosaccharides of the eastern quoll (Dasyurus viverrinus).
PubMed:
Attenuation of food allergy symptoms following treatment with human milk oligosaccharides in a mouse model.
PubMed:
Comparison of milk oligosaccharides pattern in colostrum of different horse breeds.
PubMed:
In vitro impact of human milk oligosaccharides on Enterobacteriaceae growth.
PubMed:
4-O-Acetyl-sialic acid (Neu4,5Ac2) in acidic milk oligosaccharides of the platypus (Ornithorhynchus anatinus) and its evolutionary significance.
PubMed:
Growth and safety evaluation of infant formulae containing oligosaccharides derived from bovine milk: a randomized, double-blind, noninferiority trial.
PubMed:
Functional role and mechanisms of sialyllactose and other sialylated milk oligosaccharides.
PubMed:
Can an ancestral condition for milk oligosaccharides be determined? Evidence from the Tasmanian echidna (Tachyglossus aculeatus setosus).
PubMed:
Select human milk oligosaccharides directly modulate peripheral blood mononuclear cells isolated from 10-d-old pigs.
PubMed:
Exposure of Bifidobacterium longum subsp. infantis to Milk Oligosaccharides Increases Adhesion to Epithelial Cells and Induces a Substantial Transcriptional Response.
PubMed:
Neutral and acidic milk oligosaccharides of the striped skunk (Mephitidae: Mephitis mephitis).
PubMed:
In vitro fermentation characteristics of select nondigestible oligosaccharides by infant fecal inocula.
PubMed:
Methodologies for screening of bacteria-carbohydrate interactions: anti-adhesive milk oligosaccharides as a case study.
PubMed:
Biotechnological production of human milk oligosaccharides.
PubMed:
Quantification of bovine milk oligosaccharides using liquid chromatography-selected reaction monitoring-mass spectrometry.
PubMed:
Chemical characterization of the oligosaccharides in Bactrian camel (Camelus bactrianus) milk and colostrum.
PubMed:
Neutral and acidic oligosaccharides in Holstein-Friesian colostrum during the first 3 days of lactation measured by high performance liquid chromatography on a microfluidic chip and time-of-flight mass spectrometry.
PubMed:
Permeate from cheese whey ultrafiltration is a source of milk oligosaccharides.
PubMed:
Determination of sialyl and neutral oligosaccharide levels in transition and mature milks of Samoan women, using anthranilic derivatization followed by reverse phase high performance liquid chromatography.
PubMed:
Genetic engineering of Escherichia coli for the economical production of sialylated oligosaccharides.
PubMed:
Sialyl oligosaccharides of human colostrum: changes in concentration during the first three days of lactation.
PubMed:
Sialyloligosaccharides in human and bovine milk and in infant formulas: variations with the progression of lactation.
PubMed:
Inhibition of Helicobacter pylori adhesion to human gastric mucus by a high-molecular-weight constituent of cranberry juice.