octyl salicylate

2-hydroxybenzoic acid octyl ester

CAS: 6969-49-9 C15 H22 O3 MW: 250.33794000

Identification

Nameoctyl salicylate
IUPACoctyl 2-hydroxybenzoate
CAS Number6969-49-9
EINECS230-190-2
FDA UNIISearch
Molecular FormulaC15 H22 O3
Molecular Weight250.33794000
Nikkaji NumberJ36.461D
Beilstein2724636
XlogP36.80 (est)

Regulatory

Physical Properties

Appearance colorless to pale yellow clear oily liquid (est)
Assay 97.00 to 100.00
Food Chemicals Codex Listed No
Specific Gravity 1.00000 to 1.02000 @ 25.00 °C.
Pounds per Gallon - (est). 8.321 to 8.487
Refractive Index 1.49000 to 1.51000 @ 20.00 °C.
Boiling Point 336.00 to 337.00 °C. @ 760.00 mm Hg
Vapor Pressure 0.000056 mmHg @ 25.00 °C. (est)
Flash Point 267.00 °F. TCC ( 130.56 °C. )
logP (o/w) 6.089 (est)
Shelf Life 24.00 month(s) or longer if stored properly.
Storage store in cool, dry place in tightly sealed containers, protected from heat and light.
Soluble in alcohol
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Cosmetic Information

CosIngcosmetic data
Cosmetic Usesperfuming agents

No sensory data available

Safety Information

Oral/Parenteral Toxicityparenteral-rabbit LD50 > 4000 mg/kg
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryfragrance agents
RIFM Fragrance Material Safety AssessmentSearch
Recommendation for octyl salicylate flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

not found in nature

Synonyms

benzoic acid, 2-hydroxy-, octyl ester benzoic acid, o-hydroxy-, octyl ester 2- hydroxy-benzoic acid octyl ester 2- hydroxybenzoic acid octyl ester o- hydroxybenzoic acid octyl ester ortho- hydroxybenzoic acid octyl ester octyl 2-hydroxybenzoate octyl o-hydroxybenzoate N- octyl o-hydroxybenzoate octyl ortho-hydroxybenzoate N- octyl ortho-hydroxybenzoate N- octyl salicylate octyl salicylate natural octyl salicylate USP salicylic acid octyl ester salicylic acid, n-octyl ester salicylic acid, octyl ester PubMed: Sunscreen protection against ultraviolet-induced oxidative stress: evaluation of reduced glutathione levels, metalloproteinase secretion, and myeloperoxidase activity. PubMed: Simultaneous determination of the UV-filters benzyl salicylate, phenyl salicylate, octyl salicylate, homosalate, 3-(4-methylbenzylidene) camphor and 3-benzylidene camphor in human placental tissue by LC-MS/MS. Assessment of their in vitro endocrine activity. PubMed: Evaluation of skin cancer chemoprevention potential of sunscreen agents using the Epstein-Barr virus early antigen activation in vitro assay. PubMed: Influence of penetration enhancer on drug permeation from volatile formulations. PubMed: Simultaneous determination of ultraviolet filters in aqueous samples by plunger-in-needle solid-phase microextraction with graphene-based sol-gel coating as sorbent coupled with gas chromatography-mass spectrometry. PubMed: Effect of ultraviolet filters on skin superoxide dismutase activity in hairless mice after a single dose of ultraviolet radiation. PubMed: Occurrence and profiles of organic sun-blocking agents in surface waters and sediments in Japanese rivers and lakes. PubMed: A rapid High Performance Liquid Chromatographic (HPLC) method for the simultaneous determination of seven UV filters found in sunscreen and cosmetics. PubMed: Oxybutynin permeation in skin: the influence of drug and solvent activity. PubMed: The effect of drug concentration on solvent activity in silicone membranes. PubMed: In vitro skin permeation evaluation: the only realistic option. PubMed: Validation of a high performance liquid chromatography method for sunscreen determination in cosmetics. PubMed: Dosage de l'octyl dimethyl PABA, de l'homosalate et de l'octyl salicylate dans les produits de protection solaire. PubMed: Validation of a HPLC method for simultaneous determination of five sunscreens in lotion preparation. PubMed: Fluorescence dynamics of three UV-B sunscreens. PubMed: Octyl salicylate: a new contact sensitivity. PubMed: Fluorescence of sunscreens adsorbed to dielectric nanospheres: parallels to optical behavior on hacat cells and skin. PubMed: Allergic contact dermatitis from octisalate and cis-3-hexenyl salicylate. PubMed: Preparation and characterization of chitosan/gelatin microcapsules containing triclosan. PubMed: Evaluation of the photostability of different UV filter combinations in a sunscreen. PubMed: Mechanisms of action of novel skin penetration enhancers: phospholipid versus skin lipid liposomes. PubMed: Optical spectroscopy of hydrophobic sunscreen molecules adsorbed to dielectric nanospheres. PubMed: Development and validation of a non-aqueous reversed-phase high-performance liquid chromatographic method for the determination of four chemical UV filters in suncare formulations. PubMed: Active ingredients in sunscreens act as topical penetration enhancers for the herbicide 2,4-dichlorophenoxyacetic acid. PubMed: Safety assessment of Salicylic Acid, Butyloctyl Salicylate, Calcium Salicylate, C12-15 Alkyl Salicylate, Capryloyl Salicylic Acid, Hexyldodecyl Salicylate, Isocetyl Salicylate, Isodecyl Salicylate, Magnesium Salicylate, MEA-Salicylate, Ethylhexyl Salicylate, Potassium Salicylate, Methyl Salicylate, Myristyl Salicylate, Sodium Salicylate, TEA-Salicylate, and Tridecyl Salicylate. PubMed: Determination of the UV filters worldwide authorised in sunscreens by high-performance liquid chromatography. Use of cyclodextrins as mobile phase modifier. PubMed: Determination of UV-filters in sunscreens by HPLC. PubMed: [Determination of sunscreen agents in cosmetic products by reversed-phase high performance liquid chromatography]. PubMed: The Use of Human Keratinocytes in the EU/COLIPA International In Vitro Phototoxicity Test Validation Study and the ECVAM/COLIPA Study on UV Filter Chemicals. PubMed: Enhanced skin permeation of sex hormones with novel topical spray vehicles. PubMed: Percutaneous penetration of octyl salicylate from representative sunscreen formulations through human skin in vitro. PubMed: Percutaneous absorption of sunscreen agents from liquid paraffin: self-association of octyl salicylate and effects on skin flux. PubMed: Prevention of UVB-induced immunosuppression in humans by a high sun protection factor sunscreen. PubMed: Indoor and outdoor efficacy testing of a broad-spectrum sunscreen against ultraviolet A radiation in psoralen-sensitized subjects. PubMed: Efficacy of a sunscreen containing butyl methoxydibenzoylmethane against ultraviolet A radiation in photosensitized subjects. PubMed: Influence of sunscreening agents on color stability of tablets coated with certified dyes III: FD&C Yellow No. 6.