octyl salicylate
2-hydroxybenzoic acid octyl ester
Identification
| Name | octyl salicylate |
| IUPAC | octyl 2-hydroxybenzoate |
| CAS Number | 6969-49-9 |
| EINECS | 230-190-2 |
| FDA UNII | Search |
| Molecular Formula | C15 H22 O3 |
| Molecular Weight | 250.33794000 |
| Nikkaji Number | J36.461D |
| Beilstein | 2724636 |
| XlogP3 | 6.80 (est) |
Regulatory
Physical Properties
| Appearance | colorless to pale yellow clear oily liquid (est) |
| Assay | 97.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Specific Gravity | 1.00000 to 1.02000 @ 25.00 °C. |
| Pounds per Gallon - (est). | 8.321 to 8.487 |
| Refractive Index | 1.49000 to 1.51000 @ 20.00 °C. |
| Boiling Point | 336.00 to 337.00 °C. @ 760.00 mm Hg |
| Vapor Pressure | 0.000056 mmHg @ 25.00 °C. (est) |
| Flash Point | 267.00 °F. TCC ( 130.56 °C. ) |
| logP (o/w) | 6.089 (est) |
| Shelf Life | 24.00 month(s) or longer if stored properly. |
| Storage | store in cool, dry place in tightly sealed containers, protected from heat and light. |
| Soluble in | alcohol |
| Similar Items | note |
Cosmetic Information
| CosIng | cosmetic data |
| Cosmetic Uses | perfuming agents |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | parenteral-rabbit LD50 > 4000 mg/kg |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | fragrance agents |
| RIFM Fragrance Material Safety Assessment | Search |
| Recommendation for octyl salicylate flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
benzoic acid, 2-hydroxy-, octyl ester
benzoic acid, o-hydroxy-, octyl ester
2-
hydroxy-benzoic acid octyl ester
2-
hydroxybenzoic acid octyl ester
o-
hydroxybenzoic acid octyl ester
ortho-
hydroxybenzoic acid octyl ester
octyl 2-hydroxybenzoate
octyl o-hydroxybenzoate
N-
octyl o-hydroxybenzoate
octyl ortho-hydroxybenzoate
N-
octyl ortho-hydroxybenzoate
N-
octyl salicylate
octyl salicylate natural
octyl salicylate USP
salicylic acid octyl ester
salicylic acid, n-octyl ester
salicylic acid, octyl ester
PubMed:
Sunscreen protection against ultraviolet-induced oxidative stress: evaluation of reduced glutathione levels, metalloproteinase secretion, and myeloperoxidase activity.
PubMed:
Simultaneous determination of the UV-filters benzyl salicylate, phenyl salicylate, octyl salicylate, homosalate, 3-(4-methylbenzylidene) camphor and 3-benzylidene camphor in human placental tissue by LC-MS/MS. Assessment of their in vitro endocrine activity.
PubMed:
Evaluation of skin cancer chemoprevention potential of sunscreen agents using the Epstein-Barr virus early antigen activation in vitro assay.
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Influence of penetration enhancer on drug permeation from volatile formulations.
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Simultaneous determination of ultraviolet filters in aqueous samples by plunger-in-needle solid-phase microextraction with graphene-based sol-gel coating as sorbent coupled with gas chromatography-mass spectrometry.
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Effect of ultraviolet filters on skin superoxide dismutase activity in hairless mice after a single dose of ultraviolet radiation.
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Occurrence and profiles of organic sun-blocking agents in surface waters and sediments in Japanese rivers and lakes.
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A rapid High Performance Liquid Chromatographic (HPLC) method for the simultaneous determination of seven UV filters found in sunscreen and cosmetics.
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Oxybutynin permeation in skin: the influence of drug and solvent activity.
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The effect of drug concentration on solvent activity in silicone membranes.
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In vitro skin permeation evaluation: the only realistic option.
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Validation of a high performance liquid chromatography method for sunscreen determination in cosmetics.
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Dosage de l'octyl dimethyl PABA, de l'homosalate et de l'octyl salicylate dans les produits de protection solaire.
PubMed:
Validation of a HPLC method for simultaneous determination of five sunscreens in lotion preparation.
PubMed:
Fluorescence dynamics of three UV-B sunscreens.
PubMed:
Octyl salicylate: a new contact sensitivity.
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Fluorescence of sunscreens adsorbed to dielectric nanospheres: parallels to optical behavior on hacat cells and skin.
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Allergic contact dermatitis from octisalate and cis-3-hexenyl salicylate.
PubMed:
Preparation and characterization of chitosan/gelatin microcapsules containing triclosan.
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Evaluation of the photostability of different UV filter combinations in a sunscreen.
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Mechanisms of action of novel skin penetration enhancers: phospholipid versus skin lipid liposomes.
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Optical spectroscopy of hydrophobic sunscreen molecules adsorbed to dielectric nanospheres.
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Development and validation of a non-aqueous reversed-phase high-performance liquid chromatographic method for the determination of four chemical UV filters in suncare formulations.
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Active ingredients in sunscreens act as topical penetration enhancers for the herbicide 2,4-dichlorophenoxyacetic acid.
PubMed:
Safety assessment of Salicylic Acid, Butyloctyl Salicylate, Calcium Salicylate, C12-15 Alkyl Salicylate, Capryloyl Salicylic Acid, Hexyldodecyl Salicylate, Isocetyl Salicylate, Isodecyl Salicylate, Magnesium Salicylate, MEA-Salicylate, Ethylhexyl Salicylate, Potassium Salicylate, Methyl Salicylate, Myristyl Salicylate, Sodium Salicylate, TEA-Salicylate, and Tridecyl Salicylate.
PubMed:
Determination of the UV filters worldwide authorised in sunscreens by high-performance liquid chromatography. Use of cyclodextrins as mobile phase modifier.
PubMed:
Determination of UV-filters in sunscreens by HPLC.
PubMed:
[Determination of sunscreen agents in cosmetic products by reversed-phase high performance liquid chromatography].
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The Use of Human Keratinocytes in the EU/COLIPA International In Vitro Phototoxicity Test Validation Study and the ECVAM/COLIPA Study on UV Filter Chemicals.
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Enhanced skin permeation of sex hormones with novel topical spray vehicles.
PubMed:
Percutaneous penetration of octyl salicylate from representative sunscreen formulations through human skin in vitro.
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Percutaneous absorption of sunscreen agents from liquid paraffin: self-association of octyl salicylate and effects on skin flux.
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Prevention of UVB-induced immunosuppression in humans by a high sun protection factor sunscreen.
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Indoor and outdoor efficacy testing of a broad-spectrum sunscreen against ultraviolet A radiation in psoralen-sensitized subjects.
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Efficacy of a sunscreen containing butyl methoxydibenzoylmethane against ultraviolet A radiation in photosensitized subjects.
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Influence of sunscreening agents on color stability of tablets coated with certified dyes III: FD&C Yellow No. 6.