tazarotene
3-pyridinecarboxylic acid, 6-[(3,4-dihydro-4,4-dimethyl-2H-1-benzothiopyran-6-yl)ethynyl]-, ethyl ester
Identification
| Name | tazarotene |
| IUPAC | ethyl 6-[2-(4,4-dimethyl-2,3-dihydrothiochromen-6-yl)ethynyl]pyridine-3-carboxylate |
| CAS Number | 118292-40-3 |
| FDA UNII | 81BDR9Y8PS |
| Molecular Formula | C21 H21 N O2 S |
| Molecular Weight | 351.46877000 |
| MDL Number | MFCD00867628 |
| Nikkaji Number | J679.813F |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Soluble in | water, 0.1085 mg/L @ 25 °C (est) |
Cosmetic Information
| CosIng | cosmetic data |
| Cosmetic Uses | skin conditioning |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | cosmetic ingredient for skin conditioning |
| Recommendation for tazarotene usage levels up to | not for fragrance use. |
| Recommendation for tazarotene flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
ethyl 6-((4,4-dimethylthiochroman-6-yl)ethynyl)nicotinate
ethyl 6-[2-(4,4-dimethyl-2,3-dihydrothiochromen-6-yl)ethynyl]pyridine-3-carboxylate
3-
pyridinecarboxylic acid, 6-[(3,4-dihydro-4,4-dimethyl-2H-1-benzothiopyran-6-yl)ethynyl]-, ethyl ester
PubMed:
Topical retinoids for acne.
PubMed:
Wrinkles.
PubMed:
A single center, pilot, double-blinded, randomized, comparative, prospective clinical study to evaluate improvements in the structure and function of facial skin with tazarotene 0.1% cream alone and in combination with GliSODin(®) Skin Nutrients Advanced Anti-Aging Formula.
PubMed:
Gene methylation in gastric cancer.
PubMed:
A status report on topical tazarotene in the management of acne vulgaris.
PubMed:
The only topical retinoid without a generic alternative: tazarotene.
PubMed:
Drug updates and approvals: 2012 in review.
PubMed:
Psoriasis (chronic plaque).
PubMed:
Wrinkles.
PubMed:
Discovery of novel regulatory peptides by reverse pharmacology: spotlight on chemerin and the RF-amide peptides metastin and QRFP.
PubMed:
An update on the safety and efficacy of topical retinoids.
PubMed:
Treatment of cutaneous T cell lymphoma: current status and future directions.
PubMed:
New treatments and therapeutic strategies for acne.