withanolide B
lycium substance B
Identification
| Name | withanolide B |
| CAS Number | 56973-41-2 |
| FDA UNII | 9YU877VU8K |
| Molecular Formula | C28 H38 O5 |
| Molecular Weight | 454.60686000 |
| MDL Number | MFCD19053156 |
| Nikkaji Number | J1.712.385H |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Soluble in | water, 1.749 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for withanolide B usage levels up to | not for fragrance use. |
| Recommendation for withanolide B flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
ergosta-2,24-dien-26-oic acid, 6,7-epoxy-5,22-dihydroxy-1-oxo-, delta-lactone, (5alpha,6alpha,7alpha,22R)-
(5alpha,6alpha,7alpha,22R)-5-
hydroxy-6,7:22,26-diepoxyergosta-2,24-diene-1,26-dione
lycium substance B
PubMed:
Determination of Withanolides in
Withania somnifera
by Liquid Chromatography: Single-Laboratory Validation, First Action 2015.17.
PubMed:
Exploring neuroprotective potential of Withania somnifera phytochemicals by inhibition of GluN2B-containing NMDA receptors: An in silico study.
PubMed:
Evaluation of the bioavailability of major withanolides of Withania somnifera using an in vitro absorption model system.
PubMed:
Sonication, Vacuum Infiltration and Thiol Compounds Enhance the Agrobacterium-Mediated Transformation Frequency of Withania somnifera (L.) Dunal.
PubMed:
Effect of carbon and nitrogen sources on in vitro flower and fruit formation and withanolides production in Withania somnifera (L.) Dunal.
PubMed:
Lycium barbarum polysaccharide improves traumatic cognition via reversing imbalance of apoptosis/regeneration in hippocampal neurons after stress.
PubMed:
Enhanced biosynthesis of withanolides by elicitation and precursor feeding in cell suspension culture of Withania somnifera (L.) Dunal in shake-flask culture and bioreactor.
PubMed:
Withania somnifera attenuates acid production, acid tolerance and extra-cellular polysaccharide formation of Streptococcus mutans biofilms.
PubMed:
A promising approach on biomass accumulation and withanolides production in cell suspension culture of Withania somnifera (L.) Dunal.
PubMed:
Optimization of elicitation conditions with methyl jasmonate and salicylic acid to improve the productivity of withanolides in the adventitious root culture of Withania somnifera (L.) Dunal.
PubMed:
New withanolides from Mandragora officinarum: first report of withanolides from the Genus Mandragora.
PubMed:
Withanolide Z, a new chlorinated withanolide from Withania somnifera.
PubMed:
Analysis of withanolides in root and leaf of Withania somnifera by HPLC with photodiode array and evaporative light scattering detection.