lapachenole
Identification
| Name | lapachenole |
| CAS Number | 573-13-7 |
| FDA UNII | Search |
| Molecular Formula | C16 H16 O2 |
| Molecular Weight | 240.30192000 |
| Nikkaji Number | J11.530D |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Soluble in | water, 1.705 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for lapachenole usage levels up to | not for fragrance use. |
| Recommendation for lapachenole flavor usage levels up to | not for flavor use. |
No supplier data available
Potential Uses
Natural Occurrence
Synonyms
6-
methoxy-2,2-dimethylbenzo[h]chromene
2H-
naphtho(1,2-b)pyran, 6-methoxy-2,2-dimethyl-
PubMed:
Naphthochromenes and Related Constituents from the Tubers of Sinningia allagophylla.
PubMed:
Chemical Constituents from Sinningia canescens and S. warmingii.
PubMed:
Simultaneous synthesis of both rings of chromenes via a benzannulation/o-quinone methide formation/electrocyclization cascade.
PubMed:
Cysteine 98 in CYP3A4 contributes to conformational integrity required for P450 interaction with CYP reductase.
PubMed:
Photochromic agents as tools for protein structure study: lapachenole is a photoaffinity ligand of cytochrome P450 3A4.
PubMed:
Fluorescent photoaffinity labeling of cytochrome P450 3A4 by lapachenole: identification of modification sites by mass spectrometry.
PubMed:
The sensitizing capacity of naturally occurring quinones. Experimental studies in guinea pigs. I. Naphthoquinones and related compounds.