galbanic acid
asacoumarin B
Identification
| Name | galbanic acid |
| CAS Number | 3566-55-0 |
| FDA UNII | 9OFS0HWC92 |
| Molecular Formula | C24 H30 O5 |
| Molecular Weight | 398.49910000 |
| Nikkaji Number | J417.959E |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Soluble in | water, 0.01312 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for galbanic acid usage levels up to | not for fragrance use. |
| Recommendation for galbanic acid flavor usage levels up to | not for flavor use. |
No supplier data available
Potential Uses
Natural Occurrence
Synonyms
asacoumarin B
2-
cyclohexene-1-butanoic acid, 6-(((2-oxo-2H-1-benzopyran-7-yl)oxy)methyl)-alpha,2,3,6-tetramethyl-
3-[(1S,2S,3S)-2,3-
dimethyl-2-[(2-oxochromen-7-yl)oxymethyl]-6-propan-2-ylidenecyclohexyl]propanoic acid
PubMed:
Anticancer Natural Coumarins as Lead Compounds for the Discovery of New Drugs.
PubMed:
Proposed binding mechanism of galbanic acid extracted from Ferula assa-foetida to DNA.
PubMed:
Combined spectroscopy and molecular modeling studies on the binding of galbanic acid and MMP9.
PubMed:
Formulation, characterization, and geno/cytotoxicity studies of galbanic acid-loaded solid lipid nanoparticles.
PubMed:
Apoptotic Effect of Galbanic Acid via Activation of Caspases and Inhibition of Mcl-1 in H460 Non-Small Lung Carcinoma Cells.
PubMed:
Galbanic acid inhibits HIF-1α expression via EGFR/HIF-1α pathway in cancer cells.
PubMed:
Evaluating the effects of galbanic acid on hydrogen peroxide-induced oxidative DNA damage in human lymphocytes.
PubMed:
Potent and selective inhibitors of class A β-lactamase: 7-prenyloxy coumarins.
PubMed:
Synthesis, biosynthesis and biological activities of galbanic acid - A review.
PubMed:
Cytotoxic activities of phytochemicals from Ferula species.
PubMed:
Farnesiferol A from Ferula persica and galbanic acid from Ferula szowitsiana inhibit P-glycoprotein-mediated rhodamine efflux in breast cancer cell lines.
PubMed:
Galbanic acid decreases androgen receptor abundance and signaling and induces G1 arrest in prostate cancer cells.
PubMed:
Methyl galbanate, a novel inhibitor of nitric oxide production in mouse macrophage RAW264.7 cells.
PubMed:
Galbanic acid isolated from Ferula assafoetida exerts in vivo anti-tumor activity in association with anti-angiogenesis and anti-proliferation.
PubMed:
Effect of galbanic Acid, a sesquiterpene coumarin from ferula szowitsiana, as an inhibitor of efflux mechanism in resistant clinical isolates of Staphylococcus aureus.
PubMed:
Galbanic acid, a cytotoxic sesquiterpene from the gum resin of Ferula asafoetida, blocks protein farnesyltransferase.
PubMed:
Evaluation of the effects of galbanic acid from Ferula szowitsiana and conferol from F. badrakema, as modulators of multi-drug resistance in clinical isolates of Escherichia coli and Staphylococcus aureus.
PubMed:
Total synthesis and structural confirmation of ent-galbanic acid and marneral.
PubMed:
Galbanic acid from Ferula szowitsiana enhanced the antibacterial activity of penicillin G and cephalexin against Staphylococcus aureus.
PubMed:
Sesquiterpene coumarins from Ferula szowitsiana and in vitro antileishmanial activity of 7-prenyloxycoumarins against promastigotes.
PubMed:
Sesquiterpene coumarins from the roots of Ferula assa-foetida.
PubMed:
[The effect of galbanic acid on the course of experimental hepatitis].
PubMed:
[The action of the sodium salt of galbanic acid in experimental erythrocyte hyperaggregation].
PubMed:
[Effect of the sodium salt of galbanic acid on thrombocyte aggregation].
PubMed:
[Changes in thrombocyte aggregation as affected by the sodium salt of galbanic acid in an experiment].
PubMed:
[Effect of the sodium salt of galbanic acid on erythrocyte aggregation in an experiment].
PubMed:
[Antibacterial activity of galbanic acid and of its conversion products].
PubMed:
[PREPARATION AND EXAMINATION OF SOME PRODUCTS IN THE CONVERSION OF GALBANIC ACID].
PubMed:
[On the problem of the isolation of galbanic acid from Ferula gumosa Boiss. roots].