galbanic acid

asacoumarin B

CAS: 3566-55-0 C24 H30 O5 MW: 398.49910000

Identification

Namegalbanic acid
CAS Number3566-55-0
FDA UNII9OFS0HWC92
Molecular FormulaC24 H30 O5
Molecular Weight398.49910000
Nikkaji NumberJ417.959E

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Soluble in water, 0.01312 mg/L @ 25 °C (est)

No sensory data available

Safety Information

Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorynatural substances and extractives
Recommendation for galbanic acid usage levels up tonot for fragrance use.
Recommendation for galbanic acid flavor usage levels up tonot for flavor use.

No supplier data available

Potential Uses

None Found

Natural Occurrence

ferula gummosa

Synonyms

asacoumarin B 2- cyclohexene-1-butanoic acid, 6-(((2-oxo-2H-1-benzopyran-7-yl)oxy)methyl)-alpha,2,3,6-tetramethyl- 3-[(1S,2S,3S)-2,3- dimethyl-2-[(2-oxochromen-7-yl)oxymethyl]-6-propan-2-ylidenecyclohexyl]propanoic acid PubMed: Anticancer Natural Coumarins as Lead Compounds for the Discovery of New Drugs. PubMed: Proposed binding mechanism of galbanic acid extracted from Ferula assa-foetida to DNA. PubMed: Combined spectroscopy and molecular modeling studies on the binding of galbanic acid and MMP9. PubMed: Formulation, characterization, and geno/cytotoxicity studies of galbanic acid-loaded solid lipid nanoparticles. PubMed: Apoptotic Effect of Galbanic Acid via Activation of Caspases and Inhibition of Mcl-1 in H460 Non-Small Lung Carcinoma Cells. PubMed: Galbanic acid inhibits HIF-1α expression via EGFR/HIF-1α pathway in cancer cells. PubMed: Evaluating the effects of galbanic acid on hydrogen peroxide-induced oxidative DNA damage in human lymphocytes. PubMed: Potent and selective inhibitors of class A β-lactamase: 7-prenyloxy coumarins. PubMed: Synthesis, biosynthesis and biological activities of galbanic acid - A review. PubMed: Cytotoxic activities of phytochemicals from Ferula species. PubMed: Farnesiferol A from Ferula persica and galbanic acid from Ferula szowitsiana inhibit P-glycoprotein-mediated rhodamine efflux in breast cancer cell lines. PubMed: Galbanic acid decreases androgen receptor abundance and signaling and induces G1 arrest in prostate cancer cells. PubMed: Methyl galbanate, a novel inhibitor of nitric oxide production in mouse macrophage RAW264.7 cells. PubMed: Galbanic acid isolated from Ferula assafoetida exerts in vivo anti-tumor activity in association with anti-angiogenesis and anti-proliferation. PubMed: Effect of galbanic Acid, a sesquiterpene coumarin from ferula szowitsiana, as an inhibitor of efflux mechanism in resistant clinical isolates of Staphylococcus aureus. PubMed: Galbanic acid, a cytotoxic sesquiterpene from the gum resin of Ferula asafoetida, blocks protein farnesyltransferase. PubMed: Evaluation of the effects of galbanic acid from Ferula szowitsiana and conferol from F. badrakema, as modulators of multi-drug resistance in clinical isolates of Escherichia coli and Staphylococcus aureus. PubMed: Total synthesis and structural confirmation of ent-galbanic acid and marneral. PubMed: Galbanic acid from Ferula szowitsiana enhanced the antibacterial activity of penicillin G and cephalexin against Staphylococcus aureus. PubMed: Sesquiterpene coumarins from Ferula szowitsiana and in vitro antileishmanial activity of 7-prenyloxycoumarins against promastigotes. PubMed: Sesquiterpene coumarins from the roots of Ferula assa-foetida. PubMed: [The effect of galbanic acid on the course of experimental hepatitis]. PubMed: [The action of the sodium salt of galbanic acid in experimental erythrocyte hyperaggregation]. PubMed: [Effect of the sodium salt of galbanic acid on thrombocyte aggregation]. PubMed: [Changes in thrombocyte aggregation as affected by the sodium salt of galbanic acid in an experiment]. PubMed: [Effect of the sodium salt of galbanic acid on erythrocyte aggregation in an experiment]. PubMed: [Antibacterial activity of galbanic acid and of its conversion products]. PubMed: [PREPARATION AND EXAMINATION OF SOME PRODUCTS IN THE CONVERSION OF GALBANIC ACID]. PubMed: [On the problem of the isolation of galbanic acid from Ferula gumosa Boiss. roots].