arborinine
Identification
| Name | arborinine |
| CAS Number | 5489-57-6 |
| FDA UNII | 16XG8UE639 |
| Molecular Formula | C16 H15 N O4 |
| Molecular Weight | 285.29935000 |
| Nikkaji Number | J13.628J |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Soluble in | water, 53.21 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for arborinine usage levels up to | not for fragrance use. |
| Recommendation for arborinine flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
9(10H)-
acridinone, 1-hydroxy-2,3-dimethoxy-10-methyl- (9CI)
1-
hydroxy-2,3-dimethoxy-10-methyl-9(10h)-acridinone
1-
hydroxy-2,3-dimethoxy-10-methylacridin-9-one
PubMed:
Phytochemical investigations and evaluation of antimutagenic activity of the alcoholic extract of Glycosmis pentaphylla and Tabernaemontana coronaria by Ames test.
PubMed:
Chalepin: isolated from Ruta angustifolia L. Pers induces mitochondrial mediated apoptosis in lung carcinoma cells.
PubMed:
Cytotoxic compounds from the fruits of Uapaca togoensis towards multifactorial drug-resistant cancer cells.
PubMed:
Inhibition of hepatitis C virus replication by chalepin and pseudane IX isolated from Ruta angustifolia leaves.
PubMed:
Ethyl acetate extract from Glycosmis parva leaf induces apoptosis and cell-cycle arrest by decreasing expression of COX-2 and altering BCL-2 family gene expression in human colorectal cancer HT-29 cells.
PubMed:
Secondary metabolites from the stem of Ravenia spectabilis Lindl.
PubMed:
Activity of selected phytochemicals against Plasmodium falciparum.
PubMed:
Synthesis of novel heme-interacting acridone derivatives to prevent free heme-mediated protein oxidation and degradation.
PubMed:
The flavonoid rutin but not the alkaloid arborinine induces apoptosis in a B-cell hybridoma cell line.
PubMed:
In silico target fishing for rationalized ligand discovery exemplified on constituents of Ruta graveolens.
PubMed:
Antitumour properties of acridone alkaloids on a murine lymphoma cell line.
PubMed:
Acridone and furoquinoline alkaloids from Teclea gerrardii (Rutaceae: Toddalioideae) of southern Africa.
PubMed:
Investigation of cytotoxic activity on human cancer cell lines of arborinine and furanoacridones isolated from Ruta graveolens.
PubMed:
Different effects of arborinine alkaloid obtained from Brazilian Erthela baihensis on spleen and thymus cells stimulated in vitro with different mitogens.
PubMed:
Antibacterial activity and cytotoxicity of extractives from Ravenia spectabilis.
PubMed:
Isolation and in vitro antiplasmodial activities of alkaloids from Teclea trichocarpa: in vivo antimalarial activity and X-ray crystal structure of normelicopicine.
PubMed:
Antifeedant constituents from Fagara macrophylla.
PubMed:
Interactions of flavonoids and other phytochemicals with adenosine receptors.
PubMed:
Acridones from Vepris fitoravina and Vepris macrophylla.
PubMed:
Antispasmogenic effect of rutamarin and arborinine on isolated smooth muscle organs.
PubMed:
[Biosynthesis of the acridine alkaloid arborinine].
PubMed:
Norarborinine, a demethylation product of arborinine.