gamma-fagarine

CAS: 524-15-2 C13 H11 N O3 MW: 229.23527000

Identification

Namegamma-fagarine
CAS Number524-15-2
FDA UNII0000524152
Molecular FormulaC13 H11 N O3
Molecular Weight229.23527000
Nikkaji NumberJ6.637K
Beilstein0212820

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Soluble in water, 8.779 mg/L @ 25 °C (est)

No sensory data available

Safety Information

Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorynatural substances and extractives
Recommendation for gamma-fagarine usage levels up tonot for fragrance use.
Recommendation for gamma-fagarine flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

aegle marmelos fruit dictamni radicis cortex

Synonyms

4,8- dimethoxyfuro[2,3-b]quinoline furo(2,3-b)quinoline, 4,8-dimethoxy- PubMed: A Novel Alkaloid Isolated from Spiranthera atlantica (Rutaceae). PubMed: Inhibition of hepatitis C virus replication by chalepin and pseudane IX isolated from Ruta angustifolia leaves. PubMed: A new quinoline alkaloid from the roots of Dictamnus angustifolius. PubMed: Secondary metabolites from the stem of Ravenia spectabilis Lindl. PubMed: Furoquinoline alkaloids isolated from Balfourodendron riedelianum as photosynthetic inhibitors in spinach chloroplasts. PubMed: 4,8-Dimeth-oxy-furo[2,3-b]quinoline (γ-fagarine). PubMed: Inhibitory alkaloids from Dictamnus dasycarpus root barks on lipopolysaccharide-induced nitric oxide production in BV2 cells. PubMed: A new quinoline epoxide from the Australian plant Drummondita calida. PubMed: Antileishmanial activity of furoquinolines and coumarins from Helietta apiculata. PubMed: Secondary metabolites and cytotoxic activities from the stem bark of Zanthoxylum nitidum. PubMed: Cytotoxic activity and cell cycle analysis of quinoline alkaloids isolated from Haplophyllum canaliculatum Boiss. PubMed: Biological activity of secondary metabolites from Peltostigma guatemalense. PubMed: Alkaloids from the roots of Zanthoxylum nitidum and their antiviral and antifungal effects. PubMed: Constituents of the root wood of Zanthoxylum wutaiense with antitubercular activity. PubMed: In vitro antiplasmodial activity of extract and constituents from Esenbeckia febrifuga, a plant traditionally used to treat malaria in the Brazilian Amazon. PubMed: In vitro and in vivo activities of Haplophyllum myrtifolium against Leishmania tropica. PubMed: Identification of Ruta graveolens L. metabolites accumulated in the presence of abiotic elicitors. PubMed: Effective biotic elicitation of Ruta graveolens L. shoot cultures by lysates from Pectobacterium atrosepticum and Bacillus sp. PubMed: Synthesis, structure and stereochemistry of quinoline alkaloids from Choisya ternata. PubMed: Isolation of limonoids and alkaloids from Phellodendron amurense and their multidrug resistance (MDR) reversal activity. PubMed: [Studies on chemical constituents in bark of dictamnus dasycarpus]. PubMed: Screening of 14 alkaloids isolated from Haplophyllum A. Juss. for their cytotoxic properties. PubMed: Two new sesquiterpenoids and anti-HIV principles from the root bark of Zanthoxylum ailanthoides. PubMed: Inhibitory effects of furoquinoline alkaloids from Melicope confusa and Dictamnus albus against human phosphodiesterase 5 (hPDE5A) in vitro. PubMed: New indolopyridoquinazoline, benzo[c]phenanthridines and cytotoxic constituents from Zanthoxylum integrifoliolum. PubMed: Antibacterial activity and cytotoxicity of extractives from Ravenia spectabilis. PubMed: A new prenylated arylnaphthalene lignan from Haplophyllum myrtifolium. PubMed: Plants traditionally prescribed to treat tazo (malaria) in the eastern region of Madagascar. PubMed: A new diprenyl coumarin and alkaloids from the bark of Zanthoxylum dimorphophyllum (Rutaceae). PubMed: Quinoline alkaloids from Acronychia laurifolia. PubMed: Mutagenic compounds in an extract from Rutae Herba (Ruta graveolens L.). II. UV-A mediated mutagenicity in the green alga Chlamydomonas reinhardtii by furoquinoline alkaloids and furocoumarins present in a commercial tincture from Rutae Herba. PubMed: The SCE-inducing potency of the furoquinoline alkaloid, gamma-fagarine, and a gamma-fagarine-containing tincture from Rutae Herba, in cultured human lymphocytes. PubMed: Mutagenicity of furoquinoline alkaloids in the Salmonella/microsome assay. Mutagenicity of dictamnine is modified by various enzyme inducers and inhibitors. PubMed: Mutagenic compounds in an extract from rutae herba (Ruta graveolens L.). I. Mutagenicity is partially caused by furoquinoline alkaloids. PubMed: Mutagenic activities of dictamnine and gamma-fagarine from dictamni radicis cortex (Rutaceae). PubMed: A Contribution to the Phytochemistry of Zanthoxylum tessmannii1. PubMed: Further alkaloids from bark of Fagara mayu. PubMed: Synthesis of dihydro-gamma-fagarine and edulitine.