cuscohygrine
Identification
| Name | cuscohygrine |
| CAS Number | 454-14-8 |
| FDA UNII | 93FJ3823VL |
| Molecular Formula | C13 H24 N2 O |
| Molecular Weight | 224.34748000 |
| Nikkaji Number | J662.616E |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Soluble in | water, 7.576e+004 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for cuscohygrine usage levels up to | not for fragrance use. |
| Recommendation for cuscohygrine flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
(R*,S*)-1,3-bis(1-
methyl-2-pyrrolidinyl)-2-propanone
1-[(2S)-1-
methylpyrrolidin-2-yl]-3-[(2R)-1-methylpyrrolidin-2-yl]propan-2-one
2-
propanone, 1,3-bis(1-methyl-2-pyrrolidinyl)-, (R*,S*)-
PubMed:
Multi-analysis determination of tropane alkaloids in cereals and solanaceaes seeds by liquid chromatography coupled to single stage Exactive-Orbitrap.
PubMed:
Behaviour of hygrine and cuscohygrine in illicit cocaine production establishes their use as markers for chewing coca leaves in contrast with cocaine abuse.
PubMed:
Possibilities for discrimination between chewing of coca leaves and abuse of cocaine by hair analysis including hygrine, cuscohygrine, cinnamoylcocaine and cocaine metabolite/cocaine ratios.
PubMed:
Application of hygrine and cuscohygrine as possible markers to distinguish coca chewing from cocaine abuse on WDT and forensic cases.
PubMed:
Production of tropane alkaloids in Hyoscyamus niger (black henbane) hairy roots grown in bubble-column and spray bioreactors.
PubMed:
Multi-development-HPTLC method for quantitation of hyoscyamine, scopolamine and their biosynthetic precursors in selected solanaceae plants grown in natural conditions and as in vitro cultures.
PubMed:
Chemical composition and biological evaluation of Physalis peruviana root as hepato-renal protective agent.
PubMed:
Hygrine and cuscohygrine as possible markers to distinguish coca chewing from cocaine abuse in workplace drug testing.
PubMed:
Tropane and pyrrolidine alkaloids from Convolvulus lanatus Vahl.
PubMed:
Heterologous expression of Vitreoscilla hemoglobin (VHb) and cultivation conditions affect the alkaloid profile of Hyoscyamus muticus hairy roots.
PubMed:
Alkaloid content of the seeds from Erythroxylum Coca var. Coca.
PubMed:
Total synthesis of (+)-dihydrocuscohygrine and cuscohygrine.
PubMed:
1-Methylpyrrolidine-2-acetic Acid is not a Precursor of Tropane Alkaloids.
PubMed:
Toxicity of field bindweed (Convolvulus arvensis) to mice.
PubMed:
Tropane alkaloids and toxicity of Convolvulus arvensis.
PubMed:
Determination and in-depth chromatographic analyses of alkaloids in South American and greenhouse-cultivated coca leaves.
PubMed:
Biological activity of the alkaloids of Erythroxylum coca and Erythroxylum novogranatense.
PubMed:
Przewalskia tangutica - A tropane alkaloid-containing plant.
PubMed:
The role of hygrine in the biosynthesis of cuscohygrine and hyoscyamine.
PubMed:
[Studies on alkaloids of Scopolia lurida Dun. Assays of atropine, scopolamine and cuscohygrine].
PubMed:
Syntheses of hygrine and cuscohygrine.