cryptochlorogenic acid
4-o-caffeoyl quinic acid
Identification
| Name | cryptochlorogenic acid |
| CAS Number | 905-99-7 |
| FDA UNII | F23DJ84IZ9 |
| Molecular Formula | C16 H18 O9 |
| Molecular Weight | 354.31226000 |
| MDL Number | MFCD10566638 |
| Nikkaji Number | J691.615E |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Soluble in | water, 4.047e+005 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for cryptochlorogenic acid usage levels up to | not for fragrance use. |
| Recommendation for cryptochlorogenic acid flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
4-o-
caffeoyl quinic acid
cinnamic acid, 3,4-dihydroxy-, 4-carboxy-2,4,6-trihydroxycyclohexyl ester
cyclohexanecarboxylic acid, 4-((3-(3,4-dihydroxyphenyl)-1-oxo-2-propenyl)oxy)-1,3,5-trihydroxy-, (1alpha,3R,4alpha,5R)-
(1alpha,3alpha,4alpha,5beta)-4-(3-(3,4-(
dihydroxyphenyl)-1-oxo-2-propenyl)oxy)-1,3,5-trihydroxycyclohexanecarboxylic acid
(3R,5R)-4-[(E)-3-(3,4-
dihydroxyphenyl)prop-2-enoyl]oxy-1,3,5-trihydroxycyclohexane-1-carboxylic acid
PubMed:
Simultaneous quantification of eight organic acid components in Artemisia capillaris Thunb (Yinchen) extract using high-performance liquid chromatography coupled with diode array detection and high-resolution mass spectrometry.
PubMed:
Comparison of Multiple Bioactive Constituents in Different Parts of Eucommia ulmoides Based on UFLC-QTRAP-MS/MS Combined with PCA.
PubMed:
Polyphenols in Kuding tea help prevent HCl/ethanol-induced gastric injury in mice.
PubMed:
NMR-driven identification of anti-amyloidogenic compounds in green and roasted coffee extracts.
PubMed:
The discovery of antibacterial natural compound based on peptide deformylase.
PubMed:
Simultaneous and fast separation of three chlorogenic acids and two flavonoids from bamboo leaves extracts using zirconia.
PubMed:
A validated UHPLC method for the determination of caffeoylquinic and di-caffeoylquinic acids in green coffee extracts using an RP-Amide fused-core column.
PubMed:
Anti-Inflammatory Effects of a Stauntonia hexaphylla Fruit Extract in Lipopolysaccharide-Activated RAW-264.7 Macrophages and Rats by Carrageenan-Induced Hind Paw Swelling.
PubMed:
[Pharmacokinetics of Mori Folium flavones and alkaloids in normal and diabetic rats].
PubMed:
[Chemical constituents from stems of Ilex asprella].
PubMed:
[Qualitative and quantitative analysis of Evodiae Fructus based on the UPLC technology].
PubMed:
[Difference of chemical constituents in Eucommiae Cortex from different habitats by LC-QTOF MS/MS].
PubMed:
Selective extraction and determination of chlorogenic acids as combined quality markers in herbal medicines using molecularly imprinted polymers based on a mimic template.
PubMed:
[Study on UHPLC fingerprint and determination of eight phenolic components of Tetrastigma hemsleyanum leaves].
PubMed:
Determination of chlorogenic acids and caffeine in homemade brewed coffee prepared under various conditions.
PubMed:
Compounds isolated from Eriobotrya deflexa leaves protect against ultraviolet radiation B-induced photoaging in human fibroblasts.
PubMed:
The hydro-alcoholic extracts of Sardinian wild thistles (Onopordum spp.) inhibit TNFα-induced IL-8 secretion and NF-κB pathway in human gastric epithelial AGS cells.
PubMed:
Mid-infrared and near-infrared spectroscopy for rapid detection of Gardeniae Fructus by a liquid-liquid extraction process.
PubMed:
Antioxidant activities of aqueous extract from Stevia rebaudiana stem waste to inhibit fish oil oxidation and identification of its phenolic compounds.
PubMed:
Intestinal transport and absorption of bioactive phenolic compounds from a chemically characterized aqueous extract of Athrixia phylicoides.
PubMed:
Pharmacokinetics and Disposition of Circulating Iridoids and Organic Acids in Rats Intravenously Receiving ReDuNing Injection.
PubMed:
[Degradation kinetics of chlorogenic acid, cryptochlorogenic acid, and neochlorogenic acid at neutral and alkaline pH values].
PubMed:
Multispectroscopic and docking studies on the binding of chlorogenic acid isomers to human serum albumin: Effects of esteryl position on affinity.
PubMed:
Comparative study of the antioxidative activities of caffeoylquinic and caffeic acids.
PubMed:
[HPLC specific chromatogram spectrum-effect relationship for Shuanghuanglian on MDCK cell injury induced by influenza A virus (H1N1)].
PubMed:
Polyphenolic profiles and antioxidant and antiradical activity of Italian berries from Vaccinium myrtillus L. and Vaccinium uliginosum L. subsp. gaultherioides (Bigelow) S.B. Young.
PubMed:
[Studies on chemical constituents of aqueous extract of Lonicera japonica flower buds].
PubMed:
[Study on Commercial Specification of Lonicerae Japonicae Flos].
PubMed:
Discovery of Anti-inflammatory Ingredients in Chinese Herbal Formula Kouyanqing Granule based on Relevance Analysis between Chemical Characters and Biological Effects.
PubMed:
Simultaneous determination of four phenolic acids and seven alkaloids in rat plasma after oral administration of traditional Chinese medicinal preparation Jinqi Jiangtang Tablet by LC-ESI-MS/MS.
PubMed:
On-line quantitative monitoring of liquid-liquid extraction of Lonicera japonica and Artemisia annua using near-infrared spectroscopy and chemometrics.
PubMed:
Phytochemistry, antioxidant capacity, total phenolic content and anti-inflammatory activity of Hibiscus sabdariffa leaves.
PubMed:
Study on the anaphylactoid of three phenolic acids in Honeysuckle.
PubMed:
[Determination of eleven major components and fingerprint chromatography for Reduning injection by UPLC].
PubMed:
Quantitative comparison of caffeoylquinic acids and flavonoids in Chrysanthemum morifolium flowers and their sulfur-fumigated products by three-channel liquid chromatography with electrochemical detection.
PubMed:
Caffeic acid derivatives from Bupleurum chinense.
PubMed:
Qualitative and quantitative analysis of the major constituents in Chinese medical preparation Lianhua-Qingwen capsule by UPLC-DAD-QTOF-MS.
PubMed:
[Caffeoylquinic acid derivatives from stems of Akebia trifoliata].
PubMed:
Pharmacokinetics screening for multi-components absorbed in the rat plasma after oral administration of traditional Chinese medicine Flos Lonicerae Japonicae-Fructus Forsythiae herb couple by sequential negative and positive ionization ultra-high-performance liquid chromatography/tandem triple quadrupole mass spectrometric detection.
PubMed:
Antioxidant activity of leaf extracts from different Hibiscus sabdariffa accessions and simultaneous determination five major antioxidant compounds by LC-Q-TOF-MS.
PubMed:
A systematic study on the influence of the main ingredients of an ivy leaves dry extract on the β2-adrenergic responsiveness of human airway smooth muscle cells.
PubMed:
UFLC/MS-IT-TOF guided isolation of anti-HBV active chlorogenic acid analogues from Artemisia capillaris as a traditional Chinese herb for the treatment of hepatitis.
PubMed:
The activity-integrated method for quality assessment of reduning injection by on-line DPPH-CE-DAD.
PubMed:
Simultaneous determination of neochlorogenic acid, chlorogenic acid, cryptochlorogenic acid and geniposide in rat plasma by UPLC-MS/MS and its application to a pharmacokinetic study after administration of Reduning injection.
PubMed:
Simultaneous determination of caffeic acid derivatives by UPLC-MS/MS in rat plasma and its application in pharmacokinetic study after oral administration of Flos Lonicerae-Fructus Forsythiae herb combination.
PubMed:
HPLC-PDA analysis and anti-inflammatory effects of Mori Cortex Radicis.
PubMed:
[Study on quality control of Houttuynia Cordata, a traditional Chinese medicine by fingerprint combined with quantitative analysis of multi-components by single marker].
PubMed:
Simultaneous determination of phenolic acids by UPLC-MS/MS in rat plasma and its application in pharmacokinetic study after oral administration of Flos Lonicerae preparations.
PubMed:
[Simultaneous determination of six organic acids in Lonicerae japonicae flos and Lonicerae flos in different habitats by HPLC].
PubMed:
New triterpenoid acyl derivatives and biological study of Manilkara zapota (L.) Van Royen fruits.
PubMed:
Simultaneous determination of 5 phenolic acids in fried Fructus xanthii from different production sites and its dispensing granules by using ultra-pressure liquid chromatography.
PubMed:
[A new method of calibration and positioning in quantitative analysis of multicomponents by single marker].
PubMed:
Antioxidant Constituents of Cotoneaster melanocarpus Lodd.
PubMed:
Polyphenol and glycoalkaloid contents in potato cultivars grown in Luxembourg.
PubMed:
[Screening based on response surface methodology of multi-fractions traditional Chinese medicine with anti-influenza virus neuraminidase activity: take shuanghuanglian injection as an example].
PubMed:
Phenolic constituents of Knautia arvensis aerial parts.
PubMed:
Technological characterization and stability of Ilex paraguariensis St. Hil. Aquifoliaceae (Maté) spray-dried powder.
PubMed:
[Simultaneous determination of 4 phenolic acids in cangerzi by ultra-performance liquid chromatography].
PubMed:
Extraction and identification of three major aldose reductase inhibitors from Artemisia montana.
PubMed:
[Simultaneous determination of chlorogenic acid, cryptochlorogenic acid, caffeic acid, naringin, hesperidin and linarin in xiao'erjinning oral liquid by an HPLC method].
PubMed:
Two new 3-benzylphthalides from Scorzonera veratrifolia Fenzl.
PubMed:
Composition of phenolic compounds and glycoalkaloids alpha-solanine and alpha-chaconine during commercial potato processing.
PubMed:
Effect of mash maceration on the polyphenolic content and visual quality attributes of cloudy apple juice.
PubMed:
Antioxidant constituents of almond [Prunus dulcis (Mill.) D.A. Webb] hulls.
PubMed:
LC/MS/MS characterization of phenolic constituents in dried plums.
PubMed:
Phenolic compounds from Hypericum perforatum.
PubMed:
Identification, quantitative determination, and antioxidative activities of chlorogenic acid isomers in prune (Prunus domestica L. ).