americanin A
Identification
| Name | americanin A |
| CAS Number | 69506-79-2 |
| FDA UNII | Search |
| Molecular Formula | C18 H16 O6 |
| Molecular Weight | 328.32072000 |
| Nikkaji Number | J1.090.840J |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Soluble in | water, 5447 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for americanin A usage levels up to | not for fragrance use. |
| Recommendation for americanin A flavor usage levels up to | not for flavor use. |
No supplier data available
Potential Uses
Natural Occurrence
Synonyms
(E)-3-[(2S,3S)-2-(3,4-
dihydroxyphenyl)-3-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]prop-2-enal
PubMed:
Suppression of melanin synthesis by Americanin A in melan-a cells via regulation of microphthalmia-associated transcription factor.
PubMed:
Antitumor Activity of Americanin A Isolated from the Seeds of Phytolacca americana by Regulating the ATM/ATR Signaling Pathway and the Skp2-p27 Axis in Human Colon Cancer Cells.
PubMed:
Chemical composition of the endocarps of fruits of Styrax officinalis L.
PubMed:
Matrix metalloproteinase-1 inhibitory activities of Morinda citrifolia seed extract and its constituents in UVA-irradiated human dermal fibroblasts.
PubMed:
Inhibitory effects of Morinda citrifolia extract and its constituents on melanogenesis in murine B16 melanoma cells.
PubMed:
Inhibitory effects of constituents of Morinda citrifolia seeds on elastase and tyrosinase.
PubMed:
Identification of novel orosensory active molecules in cured vanilla Beans (Vanilla planifolia).
PubMed:
Lignans and anthraquinones from the fruits of Morinda citrifolia.
PubMed:
Americanin, a bioactive dibenzylbutyrolactone lignan, from the seeds of Centaurea americana.
PubMed:
Chemical constituents of the fruits of Morinda citrifolia (Noni) and their antioxidant activity.
PubMed:
Chemical constituents of Morinda citrifolia fruits inhibit copper-induced low-density lipoprotein oxidation.
PubMed:
Sesquineolignans and other constituents from the seeds of Joannesia princeps.
PubMed:
Isolation and characterization of americanin, a specific inhibitor of thrombin, from the salivary glands of the lone star tick Amblyomma americanum (L.).
PubMed:
Structures of americanol A and isoamericanol A having a neurotrophic property from the seeds of Phytolacca americana.
PubMed:
Total synthesis of neolignans, americanin A and isoamericanin A.