eupha-8,24-dienol

CAS: 514-47-6 C30 H50 O MW: 426.72770000

Identification

Nameeuphol
CAS Number514-47-6
FDA UNIISearch
Molecular FormulaC30 H50 O
Molecular Weight426.72770000
Nikkaji NumberJ14.838E
Beilstein3596105

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Soluble in water, 4.105e-006 mg/L @ 25 °C (est)

No sensory data available

Safety Information

Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorynatural substances and extractives
Recommendation for euphol usage levels up tonot for fragrance use.
Recommendation for euphol flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

vitellaria paradoxa seed oil

Synonyms

eupha-8,24-dienol 13-alpha,14-beta,17-beta-H- lanosta-8,24-dien-3-beta-ol (7CI,8CI) (3S,5R,10S,13S,14S,17S)-4,4,10,13,14- pentamethyl-17-[(2R)-6-methylhept-5-en-2-yl]-2,3,5,6,7,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-ol PubMed: Comparative Transcriptome Analysis Identifies Putative Genes Involved in Steroid Biosynthesis in Euphorbia tirucalli. PubMed: [Acute toxicity of Euphorbiae Pekinensis Radix and vinegar-processing Euphorbiae Pekinensis Radix on zebrafish embryo]. PubMed: Anti-HIV activity of southern African plants: Current developments, phytochemistry and future research. PubMed: Euphorbia neriifolia L.: Review on botany, ethnomedicinal uses, phytochemistry and biological activities. PubMed: Antibacterial activities of the methanol extract, fractions and compounds from Elaeophorbia drupifera (Thonn.) Stapf. (Euphorbiaceae). PubMed: Cytotoxic biomonitored study of Euphorbia umbellata (Pax) Bruyns. PubMed: Euphol from Euphorbia tirucalli Negatively Modulates TGF-β Responsiveness via TGF-β Receptor Segregation inside Membrane Rafts. PubMed: The antinociceptive effects of the tetracyclic triterpene euphol in inflammatory and neuropathic pain models: The potential role of PKCε. PubMed: Chemical Constituents from the Leaves of Euphorbia ammak Growing in Saudi Arabia. PubMed: [Chemical constituents from Euphorbia lunulata]. PubMed: Quantitative determination of euphol in rat plasma by LC-MS/MS and its application to a pharmacokinetic study. PubMed: Chemical and pharmacological investigation of the stem bark of Synadenium grantii. PubMed: Minor ent-abietane diterpenoids from Euphorbia guyoniana. PubMed: Antitumoural effect of Synadenium grantii Hook f. (Euphorbiaceae) latex. PubMed: Euphol arrests breast cancer cells at the G1 phase through the modulation of cyclin D1, p21 and p27 expression. PubMed: Non-toxic melanin production inhibitors from Garcinia livingstonei (Clusiaceae). PubMed: Bio-guided isolation of the cytotoxic terpenoids from the roots of Euphorbia kansui against human normal cell lines L-O2 and GES-1. PubMed: The role of PKC/ERK1/2 signaling in the anti-inflammatory effect of tetracyclic triterpene euphol on TPA-induced skin inflammation in mice. PubMed: [Optimization of vinegar processing technique of Euphorbia pekinensis by multi-index orthogonal test]. PubMed: Euphol from Euphorbia tirucalli selectively inhibits human gastric cancer cell growth through the induction of ERK1/2-mediated apoptosis. PubMed: Euphol, a tetracyclic triterpene produces antinociceptive effects in inflammatory and neuropathic pain: the involvement of cannabinoid system. PubMed: Euphol prevents experimental autoimmune encephalomyelitis in mice: evidence for the underlying mechanisms. PubMed: Preventive and therapeutic euphol treatment attenuates experimental colitis in mice. PubMed: Antileishmanial and antitrypanosomal activity of triterpene derivatives from latex of two Euphorbia species. PubMed: [Anti-HBV constituents from Euphorbia fischeriana]. PubMed: Antimicrobial activities of the methanol extract, fractions and compounds from Ficus polita Vahl. (Moraceae). PubMed: Discovery of potent and reversible monoacylglycerol lipase inhibitors. PubMed: Bioactive triterpene derivatives from latex of two Euphorbia species. PubMed: [Study on chemical constituents of Euphorbia hylonoma hand. -Mazz]. PubMed: [Studies on constituents from roots of Euphorbia hylonoma]. PubMed: [Studies on chemical constitutes of green alga Chaetomorpha basiretorsa and their bioactivity]. PubMed: Enzymatic cyclization of 22,23-dihydro-2,3-oxidosqualene into euph-7-en-3beta-ol and bacchar-12-en-3beta-ol by recombinant beta-amyrin synthase. PubMed: A new tetracyclic triterpene from the latex of Euphorbia nerifolia. PubMed: Euphane and tirucallane triterpenes from the roots of Euphorbia kansui and their in vitro effects on the cell division of Xenopus. PubMed: Eupha-7,9(11),24-trien-3beta-ol ("antiquol C") and other triterpenes from Euphorbia antiquorum latex and their inhibitory effects on Epstein-Barr virus activation. PubMed: Inhibitory effect of euphol, a triterpene alcohol from the roots of Euphorbia kansui, on tumour promotion by 12-O-tetradecanoylphorbol-13-acetate in two-stage carcinogenesis in mouse skin. PubMed: Triterpene alcohols from camellia and sasanqua oils and their anti-inflammatory effects. PubMed: [Triterpene constituents from Euphorbia nematocypha Hand-Mazz]. PubMed: Analysis of a thread used in the Kshara Sutra treatment in the Ayurvedic medicinal system. PubMed: Hypotensive activity of 8,24-euphadien-3 beta-ol (euphol). PubMed: Studies in the Chemical Constituents of Azadirachta indica Part II: Isolation and Structure of the New Triterpenoid Azadirachtol. PubMed: Rotational isomerism about the 17(20)-bond of steroids and euphoids as shown by the crystal structures of euphol and tirucallol. PubMed: [Studies on the constituents of Chinese drug "kanzui." 8. KMnO4 oxidation of euphol, tirucallol and beta-euphorbol].