4-nerolidyl catechol
Identification
| Name | 4-nerolidyl catechol |
| CAS Number | 74683-11-7 |
| FDA UNII | Search |
| Molecular Formula | C21 H30 O2 |
| Molecular Weight | 314.46850000 |
| Nikkaji Number | J911.662A |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Soluble in | water, 0.007014 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for 4-nerolidyl catechol usage levels up to | not for fragrance use. |
| Recommendation for 4-nerolidyl catechol flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
1,2-
benzenediol, 4-(1-ethenyl-1,5,9-trimethyl-4,8-decadienyl)-
4-
nerolidylcatechol
4-[(6E)-3,7,11-
trimethyldodeca-1,6,10-trien-3-yl]benzene-1,2-diol
PubMed:
4-Nerolidylcatechol: apoptosis by mitochondrial mechanisms with reduction in cyclin D1 at G0/G1 stage of the chronic myelogenous K562 cell line.
PubMed:
Liposomal Entrapment of 4-Nerolidylcatechol: Impact on Phospholipid Dynamics, Drug Stability and Bioactivity.
PubMed:
4-Nerolidylcatechol analogues as promising anticancer agents.
PubMed:
In vivo antimalarial activity and mechanisms of action of 4-nerolidylcatechol derivatives.
PubMed:
Anticancer and Anti-Inflammatory Activities of a Standardized Dichloromethane Extract from Piper umbellatum L. Leaves.
PubMed:
Antioxidant effect of 4-nerolidylcatechol and α-tocopherol in erythrocyte ghost membranes and phospholipid bilayers.
PubMed:
Evaluation of antimicrobial and antimalarial activities of crude extract, fractions and 4-nerolidylcathecol from the aerial parts of Piper umbellata L. (Piperaceae).
PubMed:
Pothomorphe umbellata: antifungal activity against strains of Trichophyton rubrum.
PubMed:
Antioxidant and cytotoxic effects of crude extract, fractions and 4-nerolidylcathecol from aerial parts of Pothomorphe umbellata L. (Piperaceae).
PubMed:
4-Nerolidylcatechol and its synthetic analogues: antioxidant activity and toxicity evaluation.
PubMed:
Anti-inflammatory and antinociceptive activities of LQFM002 - A 4-nerolidylcatechol derivative.
PubMed:
Stability and antioxidant activity of semi-synthetic derivatives of 4-nerolidylcatechol.
PubMed:
Anti-inflammatory effect of (E)-4-(3,7-dimethylocta-2,6-dienylamino)phenol, a new derivative of 4-nerolidylcatechol.
PubMed:
Proteasome inhibition and ROS generation by 4-nerolidylcatechol induces melanoma cell death.
PubMed:
Impact of ultrasound-assisted extraction on quality and photostability of the Pothomorphe umbellata extracts.
PubMed:
In vivo and in vitro antimalarial activity of 4-nerolidylcatechol.
PubMed:
Piper peltatum: biomass and 4-nerolidylcatechol production.
PubMed:
New antimalarial and cytotoxic 4-nerolidylcatechol derivatives.
PubMed:
Apoptosis induction by 4-nerolidylcatechol in melanoma cell lines.
PubMed:
Bioactive aristolactams from Piper umbellatum.
PubMed:
Dose-dependent in vitro inhibition of rabbit corneal matrix metalloproteinases by an extract of Pothomorphe umbellata after alkali injury.
PubMed:
Protective effects of 4-nerolidylcatechol against genotoxicity induced by cyclophosphamide.
PubMed:
In vitro inhibition of Plasmodium falciparum by substances isolated from Amazonian antimalarial plants.
PubMed:
In vitro and in vivo inhibition of skin matrix metalloproteinases by Pothomorphe umbellata root extract.
PubMed:
Chemical stability and SPF determination of Pothomorphe umbellata extract gel and photostability of 4-nerolidylcathecol.
PubMed:
Inhibitory effects of Piper umbellatum and Piper peltatum extracts towards myotoxic phospholipases A2 from Bothrops snake venoms: isolation of 4-nerolidylcatechol as active principle.
PubMed:
Evaluation of percutaneous absorption of 4-nerolidylcathecol from four topical formulations.
PubMed:
Investigation of the larvicidal activity of Pothomorphe peltata and isolation of the active constituent.
PubMed:
Cytotoxic 4-nerolidylcatechol from Pothomorphe peltata inhibits topoisomerase I activity.
PubMed:
4-Nerolidylcatechol from Pothomorphe spp. scavenges peroxyl radicals and inhibits Fe(II)-dependent DNA damage.