ganoderic acid DM
Identification
| Name | ganoderic acid DM |
| CAS Number | 173075-45-1 |
| FDA UNII | Search |
| Molecular Formula | C30 H44 O4 |
| Molecular Weight | 468.67748000 |
| MDL Number | MFCD04039843 |
| Nikkaji Number | J2.046.033D |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Soluble in | water, 0.0004257 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for ganoderic acid DM usage levels up to | not for fragrance use. |
| Recommendation for ganoderic acid DM flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
(E,6R)-2-
methyl-6-[(5R,10S,13R,14R,17R)-4,4,10,13,14-pentamethyl-3,7-dioxo-2,5,6,11,12,15,16,17-octahydro-1H-cyclopenta[a]phenanthren-17-yl]hept-2-enoic acid
PubMed:
Anticancer Activity of Ganoderic Acid DM: Current Status and Future Perspective.
PubMed:
Novel binding patterns between ganoderic acids and neuraminidase: Insights from docking, molecular dynamics and MM/PBSA studies.
PubMed:
Distinct Responses of Cytotoxic Ganoderma lucidum Triterpenoids in Human Carcinoma Cells.
PubMed:
A novel component from citrus, ginger, and mushroom family exhibits antitumor activity on human meningioma cells through suppressing the Wnt/β-catenin signaling pathway.
PubMed:
Target proteins of ganoderic acid DM provides clues to various pharmacological mechanisms.
PubMed:
A possible cross-talk between autophagy and apoptosis in generating an immune response in melanoma.
PubMed:
Ganoderic acid DM, a natural triterpenoid, induces DNA damage, G1 cell cycle arrest and apoptosis in human breast cancer cells.
PubMed:
Macromolecular and small-molecule modulation of intracellular Aβ42 aggregation and associated toxicity.
PubMed:
Ganoderic Acid DM: An Alternative Agent for the Treatment of Advanced Prostate Cancer.
PubMed:
Ganoderic acid DM: anti-androgenic osteoclastogenesis inhibitor.
PubMed:
Regulation of osteoclastogenesis by ganoderic acid DM isolated from Ganoderma lucidum.
PubMed:
Quality evaluation of Ganoderma through simultaneous determination of nine triterpenes and sterols using pressurized liquid extraction and high performance liquid chromatography.
PubMed:
5alpha-reductase inhibitory effect of triterpenoids isolated from Ganoderma lucidum.
PubMed:
[Studies on the ganoderic acid, a new constituents from the fruiting body of Ganoderma lucidum (Fr.) Karst].