(±)-aegeline
Identification
| Name | (±)-aegeline |
| CAS Number | 456-12-2 |
| FDA UNII | 60T59LN3SG |
| Molecular Formula | C18 H19 N O3 |
| Molecular Weight | 297.35403000 |
| MDL Number | MFCD00048045 |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Soluble in | water, 235.3 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for (±)-aegeline usage levels up to | not for fragrance use. |
| Recommendation for (±)-aegeline flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
N-(2-
hydroxy-2(4-methoxyphenyl)ethyl)-3-phenyl-2-propenamide, (E)-
(E)-N-[2-
hydroxy-2-(4-methoxyphenyl)ethyl]-3-phenylprop-2-enamide
2-
propenamide, N-(2-hydroxy-2-(4-methoxyphenyl)ethyl)-3-phenyl-, (E)-
PubMed:
Pharmacokinetics and Tissue Distribution of Aegeline after Oral Administration in Mice
PubMed:
Overview of regulation of dietary supplements in the USA and issues of adulteration with phenethylamines (PEAs)
PubMed:
Aegeline from Aegle marmelos stimulates glucose transport via Akt and Rac1 signaling, and contributes to a cytoskeletal rearrangement through PI3K/Rac1
PubMed:
Aegeline, a natural product from the plant Aegle marmelos, mimics the yeast SNARE protein Sec22p in suppressing à-synuclein and Bax toxicity in yeast
PubMed:
Aegeline inspired synthesis of novel amino alcohol and thiazolidinedione hybrids with antiadipogenic activity in 3T3-L1 cells
PubMed:
Simultaneous Determination of Aegeline and Six Coumarins from Different Parts of the Plant Aegle marmelos Using UHPLC-PDA-MS and Chiral Separation of Aegeline Enantiomers Using HPLC-ToF-MS
PubMed:
Aegeline inspired synthesis of novel ?3-AR agonist improves insulin sensitivity in vitro and in vivo models of insulin resistance
PubMed:
LOX-1, the Common Therapeutic Target in Hypercholesterolemia: A New Perspective of Antiatherosclerotic Action of Aegeline
PubMed:
Corrigendum to "Aegeline, a natural product from the plant Aegle marmelos, mimics the yeast SNARE protein Sec22p in suppressing à-synuclein and Bax toxicity in yeast" [Bioorg. Med. Chem. Lett. 29 (2019) 454-460]
PubMed:
Effects of aegeline, a main alkaloid of Aegle Marmelos Correa leaves, on the histamine release from mast cells
PubMed:
Inhibition of CYP3A4 and CYP1A2 by Aegle marmelos and its constituents
PubMed:
Lipid lowering agents of natural origin: An account of some promising chemotypes
PubMed:
Antihyperglycemic and antidyslipidemic agent from Aegle marmelos
PubMed:
Interaction of active compounds from Aegle marmelos CORREA with histamine-1 receptor
PubMed:
The Role of Adverse Event Reporting in the FDA Response to a Multistate Outbreak of Liver Disease Associated with a Dietary Supplement
PubMed:
Two new cytotoxic furoquinoline alkaloids isolated from Aegle marmelos (Linn.) Correa
PubMed:
Synthesis of novel N-(2-hydroxy-2-p-tolylethyl)-amide and N-(2-oxo-2-p-tolylethyl)-amide derivatives and their antidyslipidemic and antioxidant activity
PubMed:
Synthesis of new N-acryl-1-amino-2-phenylethanol and N-acyl-1-amino-3-aryloxypropanols and evaluation of their antihyperlipidemic, LDL-oxidation and antioxidant activity
PubMed:
Anti adipogenic activity of Aegle marmelos Correa
PubMed:
Biological Evaluation of Aegle marmelos Fruit Extract and Isolated Aegeline in Alleviating Pain-Depression Dyad: In Silico Analysis of Aegeline on MAO-A and iNOS
PubMed:
ACTION OF RANEY NICKEL ON AEGELINE, AEGELONE AND DIHYDROAEGELINE
PubMed:
Outbreak of severe hepatitis linked to weight-loss supplement OxyELITE Pro
PubMed:
Hydrosoluble formazan XTT: its application to natural products drug discovery for Leishmania
PubMed:
Severe Acute Hepatocellular Injury Attributed to OxyELITE Pro: A Case Series
PubMed:
Binolam-AlCl: a two-centre catalyst for the synthesis of enantioenriched cyanohydrin O-phosphates