clitocine

6- amino-5-nitro-4-(ribofuranosylamino)pyrimidine (2R,3R,4S,5R)-2-[(6- amino-5-nitropyrimidin-4-yl)amino]-5-(hydroxymethyl)oxolane-3,4-diol beta-D- ribofuranosylamine, N-(6-amino-5-nitro-4-pyrimidinyl)- PubMed: The nucleoside analog clitocine is a potent and efficacious readthrough agent. PubMed: Clitocine potentiates TRAIL-mediated apoptosis in human colon cancer cells by promoting Mcl-1 degradation. PubMed: Clitocine induces apoptosis and enhances the lethality of ABT-737 in human colon cancer cells by disrupting the interaction of Mcl-1 and Bak. PubMed: Clitocine targets Mcl-1 to induce drug-resistant human cancer cell apoptosis in vitro and tumor growth inhibition in vivo. PubMed: Clitocine reversal of P-glycoprotein associated multi-drug resistance through down-regulation of transcription factor NF-κB in R-HepG2 cell line. PubMed: Anti-proliferative effect of clitocine from the mushroom Leucopaxillus giganteus on human cervical cancer HeLa cells by inducing apoptosis. PubMed: In vivo antitumor activity of clitocine, an exocyclic amino nucleoside isolated from Lepista inversa. PubMed: Solid-phase synthesis of 5'-deoxy-5'-amino-clitocine analogues. PubMed: Synthesis and biological evaluation of clitocine analogues as adenosine kinase inhibitors. PubMed: Synthesis and biological activities of new carbaacyclonucleosides and 1'-oxaacyclonucleosides related to clitocine. PubMed: Synthesis, intramolecular hydrogen bonding, and biochemical studies of clitocine, a naturally occurring exocyclic amino nucleoside.