isoliensinine

(1R)-1-[[4- hydroxy-3-[[(1R)-6-methoxy-1-[(4-methoxyphenyl)methyl]-2-methyl-3,4-dihydro-1H-isoquinolin-7-yl]oxy]phenyl]methyl]-6-methoxy-2-methyl-3,4-dihydro-1H-isoquinolin-7-ol 7-iso quinolinol, 1,2,3,4-tetrahydro-1-((4-hydroxy-3-((1,2,3,4-tetrahydro-6-methoxy-1-((4-methoxyphenyl)methyl)-2-methyl-7-isoquinolinyl)oxy)phenyl)methyl)-6-methoxy-2-methyl-, (R-(R*,R*))- PubMed: [Studies on the chemical components of Nelumbinis Plumula and the inhibitory activity on protein disulfide isomerase]. PubMed: Isolation and identification of a tribenzylisoquinoline alkaloid from Nelumbo nucifera Gaertn, a novel potential smooth muscle relaxant. PubMed: Activity of Isoliensinine in Improving the Symptoms of Type 2 Diabetic Mice via Activation of AMP-Activated Kinase and Regulation of PPARγ. PubMed: A general ionic liquid pH-zone-refining countercurrent chromatography method for separation of alkaloids from Nelumbo nucifera Gaertn. PubMed: K-targeted strategy for isolation of phenolic alkaloids of Nelumbo nucifera Gaertn by counter-current chromatography using lysine as a pH regulator. PubMed: Glucocorticoid-Induced Leucine Zipper Suppresses ICAM-1 and MCP-1 Expression by Dephosphorylation of NF-κB p65 in Retinal Endothelial Cells. PubMed: Anti-ageing active ingredients from herbs and nutraceuticals used in traditional Chinese medicine: pharmacological mechanisms and implications for drug discovery. PubMed: Isoliensinine induces dephosphorylation of NF-kB p65 subunit at Ser536 via a PP2A-dependent mechanism in hepatocellular carcinoma cells: roles of impairing PP2A/I2PP2A interaction. PubMed: A Comprehensive Review on Chemical Profiling of Nelumbo Nucifera: Potential for Drug Development. PubMed: [Metabolites Identification for Alkaloids from Nelumbinis Plumula in Caco-2 Cells by LC/MS/MS]. PubMed: Hernandezine, a novel AMPK activator induces autophagic cell death in drug-resistant cancers. PubMed: Isoliensinine, a Bioactive Alkaloid Derived from Embryos of Nelumbo nucifera, Induces Hepatocellular Carcinoma Cell Apoptosis through Suppression of NF-κB Signaling. PubMed: Serotonergic mechanisms are involved in antidepressant-like effects of bisbenzylisoquinolines liensinine and its analogs isolated from the embryo of Nelumbo nucifera Gaertner seeds in mice. PubMed: Isoliensinine induces apoptosis in triple-negative human breast cancer cells through ROS generation and p38 MAPK/JNK activation. PubMed: A simple U-HPLC-MS/MS method for the determination of liensinine and isoliensinine in rat plasma. PubMed: Simultaneous determination of liensinine, isoliensinine and neferine in rat plasma by UPLC-MS/MS and application of the technique to pharmacokinetic studies. PubMed: Natural small-molecule enhancers of autophagy induce autophagic cell death in apoptosis-defective cells. PubMed: Comparative analysis of antioxidant activity and functional components of the ethanol extract of lotus (Nelumbo nucifera) from various growing regions. PubMed: Protective effects of alkaloid compounds from Nelumbinis Plumula on tert-butyl hydroperoxide-induced oxidative stress. PubMed: In vitro characterization of ABC transporters involved in the absorption and distribution of liensinine and its analogs. PubMed: Analysis of alkaloids in Lotus (Nelumbo nucifera Gaertn.) leaves by non-aqueous capillary electrophoresis using ultraviolet and mass spectrometric detection. PubMed: The interaction between human breast cancer resistance protein (BCRP) and five bisbenzylisoquinoline alkaloids. PubMed: Simultaneous separation, identification and activity evaluation of three butyrylcholinesterase inhibitors from Plumula nelumbinis using on-line HPLC-UV coupled with ESI-IT-TOF-MS and BChE biochemical detection. PubMed: Synthesis and pharmacological activity of alkaloids from embryo of lotus, Nelumbo nucifera. PubMed: Identification of three new N-demethylated and O-demethylated bisbenzylisoquinoline alkaloid metabolites of isoliensinine from dog hepatic microsomes. PubMed: [Influence of isoliensinine on activity of CYP3A in rats]. PubMed: Rapid determination of three alkaloids from Lotus Plumule in human serum using an HPLC-DAD method with a short monolithic column. PubMed: Simultaneous determination of liensinine, isoliensinine and neferine from seed embryo of Nelumbo nucifera Gaertn. in rat plasma by a rapid HPLC method and its application to a pharmacokinetic study. PubMed: Bisbenzylisoquinoline Alkaloids from Nelumbo nucifera. PubMed: Semi-preparative high-speed counter-current chromatography separation of alkaloids from embryo of the seed of Nelumbo nucifera Gaertn by pH-gradient elution. PubMed: Preparative separation of alkaloids from Nelumbo nucifera Gaertn by pH-zone-refining counter-current chromatography. PubMed: Preparative separation and purification of liensinine, isoliensinine and neferine from seed embryo of Nelumbo nucifera GAERTN using high-speed counter-current chromatography. PubMed: [Metabolic products and pathway of neferine in rat liver]. PubMed: [Determination of three alkaloids in total alkaloids exfracts from Lotus plumule by RP-HPLC]. PubMed: Pharmacokinetics and metabolism of neferine in rats after a single oral administration. PubMed: [Study on preparation technology of plumula nelumbinis Alkaloid Dripping Pill and determination of content by HPLC]. PubMed: Fragmentation study on the phenolic alkaloid neferine and its analogues with anti-HIV activities by electrospray ionization tandem mass spectrometry with hydrogen/deuterium exchange and its application for rapid identification of in vitro microsomal metabolites of neferine. PubMed: Effects of isoliensinine on angiotensin II-induced proliferation of porcine coronary arterial smooth muscle cells. PubMed: Separation, identification and rapid determination of liensine, isoliensinine and neferine from embryo of the seed of Nelumbo nucifera Gaertn. by liquid chromatography coupled to diode array detector and tandem mass spectrometry. PubMed: Effects of isoliensinine on proliferation of porcine coronary arterial smooth muscle cells induced by phenylephrine. PubMed: Inhibitory effects of isoliensinine on bleomycin-induced pulmonary fibrosis in mice. PubMed: Anti-HIV benzylisoquinoline alkaloids and flavonoids from the leaves of Nelumbo nucifera, and structure-activity correlations with related alkaloids. PubMed: NMR spectroscopic analysis of neferine and isoliensinine. PubMed: Preparative counter-current chromatography isolation of liensinine and its analogues from embryo of the seed of Nelumbo nucifera GAERTN. using upright coil planet centrifuge with four multilayer coils connected in series. PubMed: [Alkaloids of plumula Nelumbinis]. PubMed: A total synthesis of isoliensinine. PubMed: On the alkaloids of Nelumbo nucifera Gaertn. 8. Studies on the alkaloids of loti embryo. 1. Structure of isoliensinine, a new biscoclaurine type alkaloid.