piperic acid
isopiperinic acid
Identification
| Name | piperic acid |
| CAS Number | 5285-18-7 |
| EINECS | 226-118-4 |
| FDA UNII | Search |
| Molecular Formula | C12 H10 O4 |
| Molecular Weight | 218.20850000 |
| MDL Number | MFCD00047282 |
| XlogP3 | 2.70 (est) |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Soluble in | water, 291.7 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for piperic acid usage levels up to | not for fragrance use. |
| Recommendation for piperic acid flavor usage levels up to | not for flavor use. |
BOC Sciences
Best of Chemicals Supplier
Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecul...
Potential Uses
Natural Occurrence
Synonyms
5-(1,3-
benzodioxol-5-yl)penta-2,4-dienoic acid
2,4-
pentadienoic acid, 5-(1,3-benzodioxol-5-yl)- (9CI)
iso
piperinic acid
PubMed:
Quantitative Structure-Cytotoxicity Relationship of Newly Synthesized Piperic Acid Esters.
PubMed:
Restoration of plasma markers of liver and kidney functions/integrity in alloxan-induced diabetic rabbits by aqueous extract of Pleurotus tuberregium sclerotia.
PubMed:
Synthesis of some monosaccharide-related ester derivatives as insecticidal and acaricidal agents.
PubMed:
Targeting P-glycoprotein: Investigation of piperine analogs for overcoming drug resistance in cancer.
PubMed:
Structure-activity relationship of piperine and its synthetic amide analogs for therapeutic potential to prevent experimentally induced ER stress in vitro.
PubMed:
Amino acid amides of piperic acid (PA) and 4-ethylpiperic acid (EPA) as NorA efflux pump inhibitors of Staphylococcus aureus.
PubMed:
Novel Piperine Derivatives with Antidiabetic Effect as PPAR-γ Agonists.
PubMed:
Inhibition of Invasion in Pancreatic Cancer Cells by Conjugate of EPA with β(3,3)-Pip-OH via PI3K/Akt/NF-kB Pathway.
PubMed:
Synthesis and biological evaluation of piperic acid amides as free radical scavengers and α-glucosidase inhibitors.
PubMed:
Synthesis and antihyperlipidemic activity of piperic acid derivatives.
PubMed:
Design, synthesis and biological evaluation of piperic acid triazolyl derivatives as potent anti-inflammatory agents.
PubMed:
Development of piperic acid derivatives from Piper nigrum as UV protection agents.
PubMed:
Derivatives form better lipoxygenase inhibitors than piperine: in vitro and in silico study.
PubMed:
Quantitative structure-cytotoxicity relationship of piperic acid amides.
PubMed:
Curcumin conjugates induce apoptosis via a mitochondrion dependent pathway in MCF-7 and MDA-MB-231 cell lines.
PubMed:
Human papilloma virus 16 E6 protein as a target for curcuminoids, curcumin conjugates and congeners for chemoprevention of oral and cervical cancers.
PubMed:
Synthesis and antileishmanial activity of piperoyl-amino acid conjugates.
PubMed:
Bioconjugates of curcumin display improved protection against glutathione depletion mediated oxidative stress in a dopaminergic neuronal cell line: Implications for Parkinson's disease.
PubMed:
Design, synthesis and characterization of some bioactive conjugates of curcumin with glycine, glutamic acid, valine and demethylenated piperic acid and study of their antimicrobial and antiproliferative properties.
PubMed:
Design, development and synthesis of mixed bioconjugates of piperic acid-glycine, curcumin-glycine/alanine and curcumin-glycine-piperic acid and their antibacterial and antifungal properties.
PubMed:
Metabolic disposition of piperine in the rat.
PubMed:
The metabolites of piperic acid and some related compounds in the rat.