liensinine

4-[[(1R)-6,7- dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-1-yl]methyl]-2-[[(1R)-1-[(4-hydroxyphenyl)methyl]-6-methoxy-2-methyl-3,4-dihydro-1H-isoquinolin-7-yl]oxy]phenol phenol, 4-((1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-isoquinolinyl)methyl)-2-((1,2,3,4-tetrahydro-1-((4-hydroxyphenyl)methyl)-6-methoxy-2-methyl-7-isoquinolinyl)oxy)-, (R-(R*,R*))- PubMed: Liensinine and Nuciferine, Bioactive Components of Nelumbo nucifera , Inhibit the Growth of Breast Cancer Cells and Breast Cancer-Associated Bone Loss. PubMed: [Studies on the chemical components of Nelumbinis Plumula and the inhibitory activity on protein disulfide isomerase]. PubMed: Isolation and identification of a tribenzylisoquinoline alkaloid from Nelumbo nucifera Gaertn, a novel potential smooth muscle relaxant. PubMed: A general ionic liquid pH-zone-refining countercurrent chromatography method for separation of alkaloids from Nelumbo nucifera Gaertn. PubMed: Effects of diacetyl-liensinine on electrophysiology in rabbit ventricular myocytes. PubMed: Initial autophagic protection switches to disruption of autophagic flux by lysosomal instability during cadmium stress accrual in renal NRK-52E cells. PubMed: Development and Characterization Pulsatile Microspheres of Nifedipine for Hypertension. PubMed: Investigation of G-quadruplex formation in the FGFR2 promoter region and its transcriptional regulation by liensinine. PubMed: A Comprehensive Review on Chemical Profiling of Nelumbo Nucifera: Potential for Drug Development. PubMed: [Metabolites Identification for Alkaloids from Nelumbinis Plumula in Caco-2 Cells by LC/MS/MS]. PubMed: Liensinine- and Neferine-Induced Cardiotoxicity in Primary Neonatal Rat Cardiomyocytes and Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes. PubMed: Hernandezine, a novel AMPK activator induces autophagic cell death in drug-resistant cancers. PubMed: Serotonergic mechanisms are involved in antidepressant-like effects of bisbenzylisoquinolines liensinine and its analogs isolated from the embryo of Nelumbo nucifera Gaertner seeds in mice. PubMed: Isoliensinine induces apoptosis in triple-negative human breast cancer cells through ROS generation and p38 MAPK/JNK activation. PubMed: A novel autophagy/mitophagy inhibitor liensinine sensitizes breast cancer cells to chemotherapy through DNM1L-mediated mitochondrial fission. PubMed: Human Ether-à-go-go Related Gene (hERG) Channel Blocking Aporphine Alkaloids from Lotus Leaves and Their Quantitative Analysis in Dietary Weight Loss Supplements. PubMed: Quantification of liensinine in rat plasma using ultra-performance liquid chromatography tandem mass spectrometry and its application to a pharmacokinetic study. PubMed: A simple U-HPLC-MS/MS method for the determination of liensinine and isoliensinine in rat plasma. PubMed: Simultaneous determination of liensinine, isoliensinine and neferine in rat plasma by UPLC-MS/MS and application of the technique to pharmacokinetic studies. PubMed: BACE1 and cholinesterase inhibitory activities of Nelumbo nucifera embryos. PubMed: Natural small-molecule enhancers of autophagy induce autophagic cell death in apoptosis-defective cells. PubMed: Protective effects of alkaloid compounds from Nelumbinis Plumula on tert-butyl hydroperoxide-induced oxidative stress. PubMed: In vitro characterization of ABC transporters involved in the absorption and distribution of liensinine and its analogs. PubMed: The interaction between human breast cancer resistance protein (BCRP) and five bisbenzylisoquinoline alkaloids. PubMed: [Effect of berberine, liensinine and neferine on HERG channel expression]. PubMed: Simultaneous separation, identification and activity evaluation of three butyrylcholinesterase inhibitors from Plumula nelumbinis using on-line HPLC-UV coupled with ESI-IT-TOF-MS and BChE biochemical detection. PubMed: Synthesis and pharmacological activity of alkaloids from embryo of lotus, Nelumbo nucifera. PubMed: Comparative effects of liensinine and neferine on the human ether-a-go-go-related gene potassium channel and pharmacological activity analysis. PubMed: Rapid determination of three alkaloids from Lotus Plumule in human serum using an HPLC-DAD method with a short monolithic column. PubMed: Simultaneous determination of liensinine, isoliensinine and neferine from seed embryo of Nelumbo nucifera Gaertn. in rat plasma by a rapid HPLC method and its application to a pharmacokinetic study. PubMed: Bisbenzylisoquinoline Alkaloids from Nelumbo nucifera. PubMed: Semi-preparative high-speed counter-current chromatography separation of alkaloids from embryo of the seed of Nelumbo nucifera Gaertn by pH-gradient elution. PubMed: Preparative separation of alkaloids from Nelumbo nucifera Gaertn by pH-zone-refining counter-current chromatography. PubMed: Preparative separation and purification of liensinine, isoliensinine and neferine from seed embryo of Nelumbo nucifera GAERTN using high-speed counter-current chromatography. PubMed: [Metabolic products and pathway of neferine in rat liver]. PubMed: [Determination of three alkaloids in total alkaloids exfracts from Lotus plumule by RP-HPLC]. PubMed: Pharmacokinetics and metabolism of neferine in rats after a single oral administration. PubMed: [Study on preparation technology of plumula nelumbinis Alkaloid Dripping Pill and determination of content by HPLC]. PubMed: Fragmentation study on the phenolic alkaloid neferine and its analogues with anti-HIV activities by electrospray ionization tandem mass spectrometry with hydrogen/deuterium exchange and its application for rapid identification of in vitro microsomal metabolites of neferine. PubMed: Separation, identification and rapid determination of liensine, isoliensinine and neferine from embryo of the seed of Nelumbo nucifera Gaertn. by liquid chromatography coupled to diode array detector and tandem mass spectrometry. PubMed: Inhibitory effects of isoliensinine on bleomycin-induced pulmonary fibrosis in mice. PubMed: Anti-HIV benzylisoquinoline alkaloids and flavonoids from the leaves of Nelumbo nucifera, and structure-activity correlations with related alkaloids. PubMed: Preparative counter-current chromatography isolation of liensinine and its analogues from embryo of the seed of Nelumbo nucifera GAERTN. using upright coil planet centrifuge with four multilayer coils connected in series. PubMed: [Determination of liensinine in plasma by high performance liquid chromatography]. PubMed: [Stability of liensinine injection]. PubMed: [Quantitative determination of liensinine in the embryo Nelumbinis (Nelumbo nucifera Gaertn.) by TLC-scanning]. PubMed: [Effects of linesinine on slow action potentials in myocardium and slow inward current in canine cardiac Purkinje fibers]. PubMed: [Pharmacokinetics of liensinine in rabbits]. PubMed: [Effects of liensinine on haemodynamics in rats and the physiologic properties of isolated rabbit atria]. PubMed: [Alkaloids of plumula Nelumbinis]. PubMed: [Studies on the alkaloids of Nelumbo nucifera Gaertn. NMR spectra of liensinine type alkaloids]. PubMed: Bisbenzylisoquinoline alkaloids and related compounds. V. A total synthesis of diastereoisomeric mixture of liensinine. PubMed: STUDIES ON THE ALKALOIDS OF EMBRYO LOTI, NELEMBO NUCIFERA GAERTIN. IV. TOTAL SYNTHESIS OF LIENSININE. PubMed: STUDIES ON THE ALKALOIDS OF EMBRYO LOTI, NELEMBO NUCIFERA GAERTIN. 3. ABSOLUTE CONFIGURATION OF LIENSININE. PubMed: [HYPOTENSIVE ACTION OF LIENSININE AND ITS TWO DERIVATIVES]. PubMed: Studies on the alkaloids of embryo loti, Nelumbo nucifera Gaertn. I. Isolation and characterisation of liensinine.