psoralidin
Identification
| Name | psoralidin |
| CAS Number | 18642-23-4 |
| FDA UNII | G16ZUQ069L |
| Molecular Formula | C20 H16 O5 |
| Molecular Weight | 336.34352000 |
| Nikkaji Number | J14.254I |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Soluble in | water, 0.9815 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for psoralidin usage levels up to | not for fragrance use. |
| Recommendation for psoralidin flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
6H-
benzofuro(3,2-c)(1)benzopyran-6-one, 3,9-dihydroxy-2-(3-methyl-2-butenyl)-
3,9-
dihydroxy-2-(3-methyl-2-butenyl)-6H-benzofuro(3,2-c)(1)benzopyran-6-one
3,9-
dihydroxy-2-(3-methylbut-2-enyl)-[1]benzofuro[3,2-c]chromen-6-one
PubMed:
Bavachalcone from Cullen corylifolium induces apoptosis and autophagy in HepG2 cells.
PubMed:
Plasma pharmacokinetics and cerebral nuclei distribution of major constituents of Psoraleae fructus in rats after oral administration.
PubMed:
Protective effects of psoralidin on ILâ1βâinduced chondrocyte apoptosis.
PubMed:
Rapid separation and simultaneous quantitative determination of 13 constituents in Psoraleae Fructus by a single marker using high-performance liquid chromatography with diode array detection.
PubMed:
Isoflavones and anti-inflammatory constituents from the fruits of Psoralea corylifolia.
PubMed:
Psoralidin suppresses osteoclastogenesis in BMMs and attenuates LPS-mediated osteolysis by inhibiting inflammatory cytokines.
PubMed:
Qualitative analysis of Psoraleae Fructus by HPLC-DAD/TOF-MS fingerprint and quantitative analysis of multiple components by single marker.
PubMed:
Inhibition of autophagy prevents cadmium-induced prostate carcinogenesis.
PubMed:
Psoralidin, a prenylated coumestan, as a novel anti-osteoporosis candidate to enhance bone formation of osteoblasts and decrease bone resorption of osteoclasts.
PubMed:
The Benzopyrone Biochanin-A as a reversible, competitive, and selective monoamine oxidase B inhibitor.
PubMed:
Targeting aberrant expression of Notch-1 in ALDH
cancer stem cells in breast cancer.
PubMed:
Synthesis of Psoralidin derivatives and their anticancer activity: First synthesis of Lespeflorin I
PubMed:
[Biosynthesis of a new psoralidin glucoside by enzymatic glycosylation].
PubMed:
Quantitative Analysis of Psoralea corylifolia Linne and its Neuroprotective and Anti-Neuroinflammatory Effects in HT22 Hippocampal Cells and BV-2 Microglia.
PubMed:
Psoralidin inhibits proliferation and enhances apoptosis of human esophageal carcinoma cells via NF-κB and PI3K/Akt signaling pathways.
PubMed:
Comparison of the in vitro metabolism of psoralidin among different species and characterization of its inhibitory effect against UDP- glucuronosyltransferase (UGT) or cytochrome p450 (CYP450) enzymes.
PubMed:
Psoralidin induced reactive oxygen species (ROS)-dependent DNA damage and protective autophagy mediated by NOX4 in breast cancer cells.
PubMed:
Nanoencapsulation of psoralidin via chitosan and Eudragit S100 for enhancement of oral bioavailability.
PubMed:
The molecular pathway of psoralidin-induced apoptosis in HepG2 cell line.
PubMed:
Quality Assessment of Psoralea fructus by HPLC Fingerprint Coupled with Multi-components Analysis.
PubMed:
Differential effect of psoralidin in enhancing apoptosis of colon cancer cells via nuclear factor-κB and B-cell lymphoma-2/B-cell lymphoma-2-associated X protein signaling pathways.
PubMed:
Inhibition behavior of fructus psoraleae's ingredients towards human carboxylesterase 1 (hCES1).
PubMed:
In vitro and in vivo assessment of the effect of antiprotozoal compounds isolated from Psoralea corylifolia against Ichthyophthirius multifiliis in fish.
PubMed:
Regio- and isoform-specific glucuronidation of psoralidin: evaluation of 3-o-glucuronidation as a functional marker for UGT1A9.
PubMed:
Plant-derived natural medicines for the management of depression: an overview of mechanisms of action.
PubMed:
Dealing naturally with stumbling blocks on highways and byways of TRAIL induced signaling.
PubMed:
Psoralidin induces autophagy through ROS generation which inhibits the proliferation of human lung cancer A549 cells.
PubMed:
Herb-drug interaction between irinotecan and psoralidin-containing herbs.
PubMed:
Psoralidin, a coumestan analogue, as a novel potent estrogen receptor signaling molecule isolated from Psoralea corylifolia.
PubMed:
[Chemical constituents from Psoralea corylifolia and their antioxidant alpha-glucosidase inhibitory and antimicrobial activities].
PubMed:
Silencing NOTCH signaling causes growth arrest in both breast cancer stem cells and breast cancer cells.
PubMed:
[Study on effect of psoralidin on anti-experimental postmenopausal osteoporosis and its mechanism].
PubMed:
Isobavachalcone and bavachinin from Psoraleae Fructus modulate Aβ42 aggregation process through different mechanisms in vitro.
PubMed:
Psoralea corylifolia L. (Buguchi) - folklore to modern evidence: review.
PubMed:
Induction of reactive oxygen species generation inhibits epithelial-mesenchymal transition and promotes growth arrest in prostate cancer cells.
PubMed:
Phenolic phytochemical displaying SARS-CoV papain-like protease inhibition from the seeds of Psoralea corylifolia.
PubMed:
The coumarin psoralidin enhances anticancer effect of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL).
PubMed:
[Study on the chemical constituents of Psoralea corylifolia].
PubMed:
[Variation of 4 kinds of compounds in Psoralea corylifolia processed by different methods].
PubMed:
Retraction. Psoralidin, an herbal molecule, inhibits phosphatidylinositol 3-kinase-mediated Akt signaling in androgen-independent prostate cancer cells.
PubMed:
Psoralidin, a dual inhibitor of COX-2 and 5-LOX, regulates ionizing radiation (IR)-induced pulmonary inflammation.
PubMed:
Enhanced TRAIL-mediated apoptosis in prostate cancer cells by the bioactive compounds neobavaisoflavone and psoralidin isolated from Psoralea corylifolia.
PubMed:
Psoralidin inhibits LPS-induced iNOS expression via repressing Syk-mediated activation of PI3K-IKK-IκB signaling pathways.
PubMed:
Activating stress-activated protein kinase-mediated cell death and inhibiting epidermal growth factor receptor signaling: a promising therapeutic strategy for prostate cancer.
PubMed:
Isolation of antioxidants from Psoralea corylifolia fruits using high-speed counter-current chromatography guided by thin layer chromatography-antioxidant autographic assay.
PubMed:
Inhibiting TNF-mediated signaling: a novel therapeutic paradigm for androgen independent prostate cancer.
PubMed:
Induction of quinone reductase activity by psoralidin isolated from Psoralea corylifolia in mouse hepa 1c1c7 cells.
PubMed:
Total synthesis of psoralidin, an anticancer natural product.
PubMed:
Psoralidin, an herbal molecule, inhibits phosphatidylinositol 3-kinase-mediated Akt signaling in androgen-independent prostate cancer cells.
PubMed:
Bioactive constituents from Chinese natural medicines. XXXIII. Inhibitors from the seeds of Psoralea corylifolia on production of nitric oxide in lipopolysaccharide-activated macrophages.
PubMed:
[Studies on chemical constituents from seed of Psoralea corylifolia].
PubMed:
Transcriptional regulation of corticotrophin releasing factor gene by furocoumarins isolated from seeds of Psoralea corylifolia.
PubMed:
Antidepressant-like effects of psoralidin isolated from the seeds of Psoralea Corylifolia in the forced swimming test in mice.
PubMed:
Chemical fingerprint and quantitative analysis of fructus psoraleae by high-performance liquid chromatography.
PubMed:
Bioactive constituents from Chinese natural medicines. XX. Inhibitors of antigen-induced degranulation in RBL-2H3 cells from the seeds of Psoralea corylifolia.
PubMed:
[Isolation and structure identification of a new isoflavone from Psoralea corylifolias].
PubMed:
Fingerprint analysis of Psoralea corylifolia L. by HPLC and LC-MS.
PubMed:
In vitro protein tyrosine phosphatase 1B inhibitory phenols from the seeds of Psoralea corylifolia.
PubMed:
Antibacterial compounds from the seeds of Psoralea corylifolia.
PubMed:
Cytotoxic constituents of Psoralea corylifolia.
PubMed:
The cytotoxicity of psoralidin from Psoralea corylifolia.