nectandrin-B

malabaricanol

CAS: 74683-16-2 C20 H24 O5 MW: 344.40728000

Identification

Namenectandrin-B
CAS Number74683-16-2
FDA UNIISearch
Molecular FormulaC20 H24 O5
Molecular Weight344.40728000
Nikkaji NumberJ259.868J

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Soluble in water, 4.369 mg/L @ 25 °C (est)

No sensory data available

Safety Information

Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorynatural substances and extractives
Recommendation for nectandrin-B usage levels up tonot for fragrance use.
Recommendation for nectandrin-B flavor usage levels up tonot for flavor use.

No supplier data available

Potential Uses

None Found

Natural Occurrence

myristica fragrans

Synonyms

calophyllin 4-[(2R,3R,4S,5S)-5-(4- hydroxy-3-methoxyphenyl)-3,4-dimethyloxolan-2-yl]-2-methoxyphenol malabaricanol nectandrin B phenol, 4,4'-((2R,3R,4S,5S)-tetrahydro-3,4-dimethyl-2,5-furandiyl)bis(2-methoxy-, rel- PubMed: Degranulation inhibitors from the arils of Myristica fragrans in antigen-stimulated rat basophilic leukemia cells. PubMed: Bioactivity-Guided Investigation of the Anti-Inflammatory Activity of Hippophae rhamnoides Fruits. PubMed: Lignans from guaiac resin decrease nitric oxide production in interleukin 1β-treated hepatocytes. PubMed: Hepatocyte-protective effect of nectandrin B, a nutmeg lignan, against oxidative stress: Role of Nrf2 activation through ERK phosphorylation and AMPK-dependent inhibition of GSK-3β. PubMed: Neolignans from the Arils of Myristica fragrans as Potent Antagonists of CC Chemokine Receptor 3. PubMed: The Blood-Brain Barrier Permeability of Lignans and Malabaricones from the Seeds of Myristica fragrans in the MDCK-pHaMDR Cell Monolayer Model. PubMed: Nectandrin B, a lignan isolated from nutmeg, inhibits liver X receptor-α-induced hepatic lipogenesis through AMP-activated protein kinase activation. PubMed: Nectandrin B suppresses the expression of adhesion molecules in endothelial cells: Role of AMP-activated protein kinase activation. PubMed: [Lignans from Machilus robusta]. PubMed: Cytotoxic and anti-tumor activities of lignans from the seeds of Vietnamese nutmeg Myristica fragrans. PubMed: Glycosides from the bark of Machilus robusta. PubMed: Protective effect of nectandrin B, a potent AMPK activator on neointima formation: inhibition of Pin1 expression through AMPK activation. PubMed: [Chemical constituents from roots of Machilus yaoshansis]. PubMed: Nectandrin B activates endothelial nitric-oxide synthase phosphorylation in endothelial cells: role of the AMP-activated protein kinase/estrogen receptor α/phosphatidylinositol 3-kinase/Akt pathway. PubMed: Neuroprotective effects of constituents of Eragrostis ferruginea against Aβ-induced toxicity in PC12 cells. PubMed: AMP-activated protein kinase (AMPK) activators from Myristica fragrans (nutmeg) and their anti-obesity effect. PubMed: Inhibition of DNA topoisomerases I and II and cytotoxicity by lignans from Saururus chinensis. PubMed: Machilin A isolated from Myristica fragrans stimulates osteoblast differentiation. PubMed: In vitro antileishmanial and antimalarial activities of tetrahydrofuran lignans isolated from Nectandra megapotamica (Lauraceae). PubMed: Protective effect of lignans against sepsis from the roots of Saururus chinensis. PubMed: Isolation and antifungal activity of lignans from Myristica fragrans against various plant pathogenic fungi. PubMed: Endiandrin A, a potent glucocorticoid receptor binder isolated from the Australian plant Endiandra anthropophagorum. PubMed: Neuroprotective effects of 2,5-diaryl-3,4-dimethyltetrahydrofuran neolignans. PubMed: Increase of caspase-3 activity by lignans from Machilus thunbergii in HL-60 cells. PubMed: Lignans from the bark of Machilus thunbergii and their DNA topoisomerases I and II inhibition and cytotoxicity. PubMed: Melanin biosynthesis inhibitors from the bark of Machilus thunbergii. PubMed: Separation of Leucas aspera, a medicinal plant of Bangladesh, guided by prostaglandin inhibitory and antioxidant activities. PubMed: Antiproliferative, anti-aromatase, anti-17beta-HSD and antioxidant activities of lignans isolated from Myristica argentea. PubMed: Chemical constituents of two Chinese Magnoliaceae plants, Tsoongiodendron odorum and Manglietiastrum sinicum, and their inhibition of platelet aggregation. PubMed: O-demethylation of 7,7'-epoxylignans by Aspergillus niger. PubMed: Antitumor plants. X. Constituents of Nectandra rigida.