nectandrin-B
malabaricanol
Identification
| Name | nectandrin-B |
| CAS Number | 74683-16-2 |
| FDA UNII | Search |
| Molecular Formula | C20 H24 O5 |
| Molecular Weight | 344.40728000 |
| Nikkaji Number | J259.868J |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Soluble in | water, 4.369 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for nectandrin-B usage levels up to | not for fragrance use. |
| Recommendation for nectandrin-B flavor usage levels up to | not for flavor use. |
No supplier data available
Potential Uses
Natural Occurrence
Synonyms
calophyllin
4-[(2R,3R,4S,5S)-5-(4-
hydroxy-3-methoxyphenyl)-3,4-dimethyloxolan-2-yl]-2-methoxyphenol
malabaricanol
nectandrin B
phenol, 4,4'-((2R,3R,4S,5S)-tetrahydro-3,4-dimethyl-2,5-furandiyl)bis(2-methoxy-, rel-
PubMed:
Degranulation inhibitors from the arils of Myristica fragrans in antigen-stimulated rat basophilic leukemia cells.
PubMed:
Bioactivity-Guided Investigation of the Anti-Inflammatory Activity of Hippophae rhamnoides Fruits.
PubMed:
Lignans from guaiac resin decrease nitric oxide production in interleukin 1β-treated hepatocytes.
PubMed:
Hepatocyte-protective effect of nectandrin B, a nutmeg lignan, against oxidative stress: Role of Nrf2 activation through ERK phosphorylation and AMPK-dependent inhibition of GSK-3β.
PubMed:
Neolignans from the Arils of Myristica fragrans as Potent Antagonists of CC Chemokine Receptor 3.
PubMed:
The Blood-Brain Barrier Permeability of Lignans and Malabaricones from the Seeds of Myristica fragrans in the MDCK-pHaMDR Cell Monolayer Model.
PubMed:
Nectandrin B, a lignan isolated from nutmeg, inhibits liver X receptor-α-induced hepatic lipogenesis through AMP-activated protein kinase activation.
PubMed:
Nectandrin B suppresses the expression of adhesion molecules in endothelial cells: Role of AMP-activated protein kinase activation.
PubMed:
[Lignans from Machilus robusta].
PubMed:
Cytotoxic and anti-tumor activities of lignans from the seeds of Vietnamese nutmeg Myristica fragrans.
PubMed:
Glycosides from the bark of Machilus robusta.
PubMed:
Protective effect of nectandrin B, a potent AMPK activator on neointima formation: inhibition of Pin1 expression through AMPK activation.
PubMed:
[Chemical constituents from roots of Machilus yaoshansis].
PubMed:
Nectandrin B activates endothelial nitric-oxide synthase phosphorylation in endothelial cells: role of the AMP-activated protein kinase/estrogen receptor α/phosphatidylinositol 3-kinase/Akt pathway.
PubMed:
Neuroprotective effects of constituents of Eragrostis ferruginea against Aβ-induced toxicity in PC12 cells.
PubMed:
AMP-activated protein kinase (AMPK) activators from Myristica fragrans (nutmeg) and their anti-obesity effect.
PubMed:
Inhibition of DNA topoisomerases I and II and cytotoxicity by lignans from Saururus chinensis.
PubMed:
Machilin A isolated from Myristica fragrans stimulates osteoblast differentiation.
PubMed:
In vitro antileishmanial and antimalarial activities of tetrahydrofuran lignans isolated from Nectandra megapotamica (Lauraceae).
PubMed:
Protective effect of lignans against sepsis from the roots of Saururus chinensis.
PubMed:
Isolation and antifungal activity of lignans from Myristica fragrans against various plant pathogenic fungi.
PubMed:
Endiandrin A, a potent glucocorticoid receptor binder isolated from the Australian plant Endiandra anthropophagorum.
PubMed:
Neuroprotective effects of 2,5-diaryl-3,4-dimethyltetrahydrofuran neolignans.
PubMed:
Increase of caspase-3 activity by lignans from Machilus thunbergii in HL-60 cells.
PubMed:
Lignans from the bark of Machilus thunbergii and their DNA topoisomerases I and II inhibition and cytotoxicity.
PubMed:
Melanin biosynthesis inhibitors from the bark of Machilus thunbergii.
PubMed:
Separation of Leucas aspera, a medicinal plant of Bangladesh, guided by prostaglandin inhibitory and antioxidant activities.
PubMed:
Antiproliferative, anti-aromatase, anti-17beta-HSD and antioxidant activities of lignans isolated from Myristica argentea.
PubMed:
Chemical constituents of two Chinese Magnoliaceae plants, Tsoongiodendron odorum and Manglietiastrum sinicum, and their inhibition of platelet aggregation.
PubMed:
O-demethylation of 7,7'-epoxylignans by Aspergillus niger.
PubMed:
Antitumor plants. X. Constituents of Nectandra rigida.