levistolide A
Identification
| Name | levistolide A |
| CAS Number | 89708-23-6 |
| FDA UNII | Search |
| Molecular Formula | C24 H28 O4 |
| Molecular Weight | 380.48396000 |
| Nikkaji Number | J470.616A |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Soluble in | water, 0.2291 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for levistolide A usage levels up to | not for fragrance use. |
| Recommendation for levistolide A flavor usage levels up to | not for flavor use. |
No supplier data available
Potential Uses
Natural Occurrence
Synonyms
(Z,Z)-
diligustilide
1H-5,10c-
ethanonaphtho(1,2-c:7,8-c')difuran-3,10-dione, 1,8-dibutylidene-5,5a,6,7,8,10b-hexahydro-, (1Z,5S,5aS,8Z,10bS,10cs)-
PubMed:
Diligustilide releases H
S and stabilizes S-nitrosothiols in ethanol-induced lesions on rat gastric mucosa.
PubMed:
Levistolide A Induces Apoptosis via ROS-Mediated ER Stress Pathway in Colon Cancer Cells.
PubMed:
The variation in the major constituents of the dried rhizome of Ligusticum chuanxiong (Chuanxiong) after herbal processing.
PubMed:
Gastroprotective effect of diligustilide isolated from roots of Ligusticum porteri coulter & rose (Apiaceae) on ethanol-induced lesions in rats.
PubMed:
Sulfur dioxide residue in sulfur-fumigated edible herbs: The fewer, the safer?
PubMed:
Vasorelaxant effects of Shunaoxin pill are mediated by NO/cGMP pathway, HO/CO pathway and calcium channel blockade in isolated rat thoracic aorta.
PubMed:
Screening anti-tumor compounds from Ligusticum wallichii using cell membrane chromatography combined with high-performance liquid chromatography and mass spectrometry.
PubMed:
Study on Pharmacokinetics of Three Preparations from Levistolide A by LC-MS-MS.
PubMed:
Optimization of high-pressure ultrasonic-assisted simultaneous extraction of six major constituents from Ligusticum chuanxiong rhizome using response surface methodology.
PubMed:
[Optimization of supercritical fluid extraction of bioactive components in Ligusticum chuanxiong by orthogonal array design].
PubMed:
[Chemical change of chuanxiong raw materials during storage].
PubMed:
Online isolation and purification of four phthalide compounds from Chuanxiong rhizoma using high-speed counter-current chromatography coupled with semi-preparative liquid chromatography.
PubMed:
Antimycobacterials from lovage root (Ligusticum officinale Koch).
PubMed:
Quantitative HPLC method for determining two of the major active phthalides from Ligusticum porteri roots.
PubMed:
Two phthalide dimers from the radix of Angelica sinensis.
PubMed:
Identification of the absorbed components and metabolites in rat plasma after oral administration of Rhizoma Chuanxiong decoction by HPLC-ESI-MS/MS.
PubMed:
[Studies on the chemical constituents of Ligusticum sinense].
PubMed:
[Studies on the chemical constituents of the root and rhizoma of Ligusticum jeholense].
PubMed:
Identification and determination of the major constituents in Traditional Chinese Medicinal formula Danggui-Shaoyao-San by HPLC-DAD-ESI-MS/MS.
PubMed:
[Study on biligustilides from Angelica sinensis].
PubMed:
Levistolide A overcomes P-glycoprotein-mediated drug resistance in human breast carcinoma cells.
PubMed:
Studies on antiproliferative effects of phthalides from Ligusticum chuanxiong in hepatic stellate cells.
PubMed:
[Studies on chemical constituents from Ligusticum glaucescens Franch].
PubMed:
Post-harvest alteration of the main chemical ingredients in Ligusticum chuanxiong Hort. (Rhizoma Chuanxiong).
PubMed:
Dimeric progestins from rhizomes of Ligusticum chuanxiong.
PubMed:
Development of high-performance liquid chromatographic fingerprints for distinguishing Chinese Angelica from related umbelliferae herbs.
PubMed:
[New dimeric phthalide derivative from Angelica sinensis].
PubMed:
[Study on fingerprint of rhizoma chuanxiong by HPLC-DAD-MS].
PubMed:
Simultaneous analysis of seventeen chemical ingredients of Ligusticum chuanxiong by on-line high performance liquid chromatography-diode array detector-mass spectrometry.