saussurea lactone

(3S,3aS,6S,7S,7aS)-6- ethenyl-3,6-dimethyl-7-prop-1-en-2-yl-3,3a,4,5,7,7a-hexahydro-1-benzofuran-2-one PubMed: Anti-allergic effects of sesquiterpene lactones from Saussurea costus (Falc.) Lipsch. determined using in vivo and in vitro experiments. PubMed: Inhibition of TNF-α-Induced Inflammation by Sesquiterpene Lactones from Saussurea lappa and Semi-Synthetic Analogues. PubMed: Costunolide and dehydrocostuslactone combination treatment inhibit breast cancer by inducing cell cycle arrest and apoptosis through c-Myc/p53 and AKT/14-3-3 pathway. PubMed: Bioassay-guided isolation of dehydrocostus lactone from Saussurea lappa: A new targeted cytosolic thioredoxin reductase anticancer agent. PubMed: "Click" reaction mediated synthesis of costunolide and dehydrocostuslactone derivatives and evaluation of their cytotoxic activity. PubMed: Costunolide induces G1/S phase arrest and activates mitochondrial-mediated apoptotic pathways in SK-MES 1 human lung squamous carcinoma cells. PubMed: A new sesquiterpenoid from Saussurea lappa roots. PubMed: Bioactivity-Guided Isolation of Antiproliferative Sesquiterpene Lactones from Centaurea solstitialis L. ssp. solstitialis. PubMed: The Genome-Wide Expression Profile of Saussurea lappa Extract on House Dust Mite-Induced Atopic Dermatitis in Nc/Nga Mice. PubMed: Potential anti-cancer activities and mechanisms of costunolide and dehydrocostuslactone. PubMed: Sesquiterpene lactones derived from Saussurea lappa induce apoptosis and inhibit invasion and migration in neuroblastoma cells. PubMed: Alantolactone from Saussurea lappa Exerts Antiinflammatory Effects by Inhibiting Chemokine Production and STAT1 Phosphorylation in TNF-α and IFN-γ-induced in HaCaT cells. PubMed: Estimation of Costunolide and Dehydrocostus Lactone in Saussurea lappa and its Polyherbal Formulations followed by their Stability Studies Using HPLC-DAD. PubMed: Inhibition of Wnt/β-Catenin Pathway by Dehydrocostus Lactone and Costunolide in Colon Cancer Cells. PubMed: UPLC/MS/MS method for quantification and cytotoxic activity of sesquiterpene lactones isolated from Saussurea lappa. PubMed: Dehydrocostuslactone inhibits LPS-induced inflammation by p38MAPK-dependent induction of hemeoxygenase-1 in vitro and improves survival of mice in CLP-induced sepsis in vivo. PubMed: Saussurea lappa Clarke-Derived Costunolide Prevents TNF α -Induced Breast Cancer Cell Migration and Invasion by Inhibiting NF- κ B Activity. PubMed: Volatile constituents of Saussurea costus roots cultivated in Uttarakhand Himalayas, India. PubMed: Pulchellamin G, an amino acid-sesquiterpene lactone, from Saussurea pulchella suppresses lipopolysaccharide-induced inflammatory responses via heme oxygenase-1 expression in murine peritoneal macrophages. PubMed: A note on Aucklandia lappa. PubMed: Studies on lymphangiogenesis inhibitors from Korean and Japanese crude drugs. PubMed: Effect of costunolide and dehydrocostus lactone on cell cycle, apoptosis, and ABC transporter expression in human soft tissue sarcoma cells. PubMed: [Chemical constituents from a portion of ethanolicextract of Saussurea lappa roots]. PubMed: NF-κB dependent anti-inflammatory activity of chlorojanerin isolated from Saussurea heteromalla. PubMed: Santamarin, a sesquiterpene lactone isolated from Saussurea lappa, represses LPS-induced inflammatory responses via expression of heme oxygenase-1 in murine macrophage cells. PubMed: Dehydrocostuslactone suppresses angiogenesis in vitro and in vivo through inhibition of Akt/GSK-3β and mTOR signaling pathways. PubMed: Essential oil composition and larvicidal activity of Saussurea lappa roots against the mosquito Aedes albopictus (Diptera: Culicidae). PubMed: The hexane extract of Saussurea lappa and its active principle, dehydrocostus lactone, inhibit prostate cancer cell migration. PubMed: Matrix solid-phase dispersion extraction coupled with HPLC-diode array detection method for the analysis of sesquiterpene lactones in root of Saussurea lappa C.B.Clarke. PubMed: Sesquiterpene lactones from Saussurea involucrata. PubMed: Antitrypanosomal sesquiterpene lactones from Saussurea costus. PubMed: Dehydrocostus lactone prevents mitochondrial dysfunction in osteoblastic MC3T3-E1 cells. PubMed: A new sesquiterpene and other constituents from Saussurea lappa root. PubMed: Quantitative analysis of costunolide and dehydrocostuslactone in rat plasma by ultraperformance liquid chromatography-electrospray ionization-mass spectrometry. PubMed: [Lactone constituents of Saussurea involucrata]. PubMed: Evaluation of anticancer activity of dehydrocostuslactone in vitro. PubMed: Dehydrocostuslactone, a medicinal plant-derived sesquiterpene lactone, induces apoptosis coupled to endoplasmic reticulum stress in liver cancer cells. PubMed: Isolation of betulinic acid, its methyl ester and guaiane sesquiterpenoids with protein tyrosine phosphatase 1B inhibitory activity from the roots of Saussurea lappa C.B.Clarke. PubMed: Apoptosis of DU145 human prostate cancer cells induced by dehydrocostus lactone isolated from the root of Saussurea lappa. PubMed: A new sesquiterpene lactone from the roots of Saussurea lappa: structure-anticancer activity study. PubMed: Sulfonated guaianolides from Saussurea lappa. PubMed: Guaiane sesquiterpene lactones and amino acid-sesquiterpene lactone conjugates from the aerial parts of Saussurea pulchella. PubMed: The chemopreventive effects of Saussurea salicifolia through induction of apoptosis and phase II detoxification enzyme. PubMed: Two new butenolide derivatives from Saussurea katochaete. PubMed: A new sesquiterpene lactone with sulfonic acid group from Saussurea lappa. PubMed: The alpha-methylene-gamma-butyrolactone moiety in dehydrocostus lactone is responsible for cytoprotective heme oxygenase-1 expression through activation of the nuclear factor E2-related factor 2 in HepG2 cells. PubMed: Sesquiterpene lactones from Saussurea alata. PubMed: Saussurea costus: botanical, chemical and pharmacological review of an ayurvedic medicinal plant. PubMed: PTP1B inhibitors from Saussrurea lappa. PubMed: Cytotoxic sesquiterpene lactones from Saussurea calcicola. PubMed: Two new sesquiterpene lactones with the sulfonic acid group from Saussurea lappa. PubMed: In vitro cytotoxicity of Mokko lactone in human leukemia HL-60 cells: induction of apoptotic cell death by mitochondrial membrane potential collapse. PubMed: Dehydrocostus lactone enhances tumor necrosis factor-alpha-induced apoptosis of human leukemia HL-60 cells. PubMed: Cytotoxic and pro-apoptotic activities of cynaropicrin, a sesquiterpene lactone, on the viability of leukocyte cancer cell lines. PubMed: Costunolide inhibits interleukin-1beta expression by down-regulation of AP-1 and MAPK activity in LPS-stimulated RAW 264.7 cells. PubMed: Cytotoxic sesquiterpene lactones from the root of Saussurea lappa. PubMed: Evaluation of sesquiterpene lactone fraction of Saussurea lappa on transudative, exudative and proliferative phases of inflammation. PubMed: Effects of sesquiterpenes and amino acid-sesquiterpene conjugates from the roots of Saussurea lappa on inducible nitric oxide synthase and heat shock protein in lipopolysaccharide-activated macrophages. PubMed: Costunolide triggers apoptosis in human leukemia U937 cells by depleting intracellular thiols. PubMed: Costunolide, a sesquiterpene lactone from Saussurea lappa, inhibits the VEGFR KDR/Flk-1 signaling pathway. PubMed: Germacrenes from fresh costus roots. PubMed: In vitro anti-inflammatory effects of cynaropicrin, a sesquiterpene lactone, from Saussurea lappa. PubMed: Inhibition of LPS-induced NO production and NF-kappaB activation by a sesquiterpene from Saussurea lappa. PubMed: A sesquiterpene, dehydrocostus lactone, inhibits the expression of inducible nitric oxide synthase and TNF-alpha in LPS-activated macrophages. PubMed: Inhibitory effect of sesquiterpene lactones from Saussurea lappa on tumor necrosis factor-alpha production in murine macrophage-like cells. PubMed: Effect of dehydrocostus lactone and costunolide from Saussurea root on the central nervous system in mice. PubMed: Costunolide and dehydrocostus lactone as inhibitors of killing function of cytotoxic T lymphocytes. PubMed: Active compounds from Saussurea lappa Clarks that suppress hepatitis B virus surface antigen gene expression in human hepatoma cells. PubMed: Saussureamines A, B, C, D, and E, new anti-ulcer principles from Chinese Saussureae Radix. PubMed: Allergic contact dermatitis to costus: removal of haptens with polymers. PubMed: Pharmacological investigations on Saussurea lappa (Clarke).