Identification

Nametriethyl orthoformate
IUPACdiethoxymethoxyethane
CAS Number122-51-0
EINECS204-550-4
FDA UNII355LRR361Q
Molecular FormulaC7 H16 O3
Molecular Weight148.20212000
MDL NumberMFCD00009230
Nikkaji NumberJ5.533F
Beilstein0605384
CoE Number10903
XlogP31.20 (est)

Regulatory

DG SANTE Food Flavourings06.096 triethoxymethane

Physical Properties

Appearance colorless clear liquid (est)
Assay 98.00 to 100.00
Food Chemicals Codex Listed No
Specific Gravity 0.88600 to 0.89500 @ 25.00 °C.
Pounds per Gallon - (est). 7.372 to 7.447
Refractive Index 1.38900 to 1.39500 @ 20.00 °C.
Melting Point -76.00 °C. @ 760.00 mm Hg
Boiling Point 144.00 °C. @ 760.00 mm Hg
Vapor Pressure 6.987000 mmHg @ 25.00 °C. (est)
Vapor Density 5.11 ( Air = 1 )
Flash Point 95.00 °F. TCC ( 35.00 °C. )
logP (o/w) 1.200
Soluble in alcohol
Insoluble in water

No sensory data available

Safety Information

Preferred SDSView
European informationMost important hazard(s):
Oral/Parenteral Toxicityoral-rat LD50 7060 mg/kg
Dermal Toxicityskin-rabbit LD50 20 ml/kg
Inhalation Toxicityinhalation-rat LCLo 4000 ppm/8H

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryflavoring agents
Recommendation for triethyl orthoformate usage levels up tonot for fragrance use.
Maximised Survey-derived Daily Intakes (MSDI-EU)0.013 (μg/capita/day)
Modified Theoretical Added Maximum Daily Intake (mTAMDI)1600 (μg/person/day)
Threshold of Concern90 (μg/person/day)
Structure ClassIII
Dairy products, excluding products of category 02.0 (01.0)3.00000
Fats and oils, and fat emulsions (type water-in-oil) (02.0)2.00000
Edible ices, including sherbet and sorbet (03.0)3.00000
Processed fruit (04.1)2.00000
Processed vegetables (incl. mushrooms & fungi, roots & tubers, pulses and legumes), and nuts & seeds (04.2)-
Confectionery (05.0)4.00000
Chewing gum (05.3)-
Cereals and cereal products, incl. flours & starches from roots & tubers, pulses & legumes, excluding bakery (06.0)2.00000
Bakery wares (07.0)5.00000
Meat and meat products, including poultry and game (08.0)1.00000
Fish and fish products, including molluscs, crustaceans and echinoderms (MCE) (09.0)1.00000
Eggs and egg products (10.0)-
Sweeteners, including honey (11.0)2.00000
Salts, spices, soups, sauces, salads, protein products, etc. (12.0)-
Foodstuffs intended for particular nutritional uses (13.0)3.00000
Non-alcoholic ("soft") beverages, excl. dairy products (14.1)2.00000
Alcoholic beverages, incl. alcohol-free and low-alcoholic counterparts (14.2)4.00000
Ready-to-eat savouries (15.0)5.00000
Composite foods (e.g. casseroles, meat pies, mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0)2.00000

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Potential Uses

None Found

Natural Occurrence

not found in nature

Synonyms

diethoxymethoxy)ethane diethoxymethoxyethane ethane, 1,1',1''-[methylidynetris(oxy)]tris- ortho formic acid ethyl ester ortho formic acid triethyl ester ortho formic acid, triethyl ester 1,1',1''-[ methanetriyltris(oxy)]triethane 1,1',1'-( methylidynetris(oxy))tris(ethane) tri ethyl orthoformate triethoxymethane triethyl -o- formate triethylorthoformate PubMed: Triethyl orthoformate mediated a novel crosslinking method for the preparation of hydrogels for tissue engineering applications: characterization and in vitro cytocompatibility analysis. PubMed: Ultrasound-promoted one-pot three component synthesis of tetrazoles catalyzed by zinc sulfide nanoparticles as a recyclable heterogeneous catalyst. PubMed: Design and synthesis of new barbituric- and thiobarbituric acid derivatives as potent urease inhibitors: Structure activity relationship and molecular modeling studies. 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PubMed: Multi-component one-pot synthesis and antimicrobial activities of 3-methyl-1,4-diphenyl-7-thioxo-4,6,8,9-tetrahydro-pyrazolo[5,4-b]pyrimidino[5,4-e]pyridine-5-one and related derivatives. PubMed: Synthesis and biological evaluation of 4-alkoxy-6,9-dichloro[1,2,4]triazolo[4,3-a]quinoxalines as inhibitors of TNF-α and IL-6. PubMed: Synthesis, Reactions and Evaluation of the Antimicrobial Activity of Some 4-(p-Halophenyl)-4H-naphthopyran, Pyranopyrimidine and Pyranotriazolopyrimidine Derivatives. PubMed: Synthesis and analgesic activity of some new pyrazoles and triazoles bearing a 6,8-dibromo-2-methylquinazoline moiety. PubMed: Single step synthesis of new fused pyrimidine derivatives and their evaluation as potent Aurora-A kinase inhibitors. PubMed: Syntheses, electronic structures, and EPR/UV-vis-NIR spectroelectrochemistry of nickel(II), copper(II), and zinc(II) complexes with a tetradentate ligand based on S-methylisothiosemicarbazide. PubMed: Concurrent esterification and N-acetylation of amino acids with orthoesters: A useful reaction with interesting mechanistic implications. PubMed: Towards the synthesis of inosine building blocks for the preparation of oligonucleotides with hydrophobic alkyl chains between the nucleotide units. PubMed: Efficient synthesis of naphtho[1,2-e][1,3]oxazine derivatives via a chemoselective reaction with the aid of low-valent titanium reagent. PubMed: One-pot synthesis of unsymmetrical N-heterocyclic carbene ligands from N-(2-iodoethyl)arylamine salts. PubMed: The synthesis of some perhydrobenzimidazolinium salts and their application in pd-carbene catalyzed heck and suzuki reactions. PubMed: An unprecedented approach to 4,5-disubstituted pyrimidine derivatives by a ZnCl(2)-catalyzed three-component coupling reaction. PubMed: Functionalization of colloidal mesoporous silica by metalorganic reagents. PubMed: First synthesis of [1,3,5-(13)C3]gallic acid. PubMed: Synthesis and antimicrobial activity of some new pyrazole, fused pyrazolo[3,4-d]-pyrimidine and pyrazolo[4,3-e][1,2,4]-triazolo[1,5-c]pyrimidine derivatives. PubMed: Synthesis and antifungal activities of novel 5-amino-6-arylamino-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one derivatives. PubMed: Synthesis, NMR and crystallographic studies of 2-substituted dihydroquinazolinones derived from (S)-phenylethylamine. PubMed: Tetraazaperopyrenes: a new class of multifunctional chromophores. PubMed: Synthesis, DNA binding and antiviral activity of new uracil, xanthine, and pteridine derivatives. PubMed: 3-[5-(4-Bromophenyl)-1H-pyrazol-3-ylamino]-5,5-dimethylcyclohex-2-en-1-one-(Z)-3-(4-bromophenyl)-3-chloroacrylonitrile (2/1): a stoichiometric cocrystal of a reaction product with one of its early precursors. PubMed: Syntheses, structures, near-infrared and visible luminescence, and magnetic properties of lanthanide-organic frameworks with an imidazole-containing flexible ligand. PubMed: Synthesis of new iso-C-nucleoside analogues from 2-(methyl 2-O-benzyl-4,6-O-benzylidene-3-deoxy-alpha-D-altropyranosid-3-yl)ethanal. PubMed: Synthesis of some new annulated pyrazolo-pyrido (or pyrano) pyrimidine, pyrazolopyridine and pyranopyrazole derivatives. PubMed: Functionalisation reactions of 2,5-diphenyl-1,3,4-oxadiazoles bearing a terminal ethynyl or butadiynyl substituent: X-ray crystal structures of the products. PubMed: Synthesis of triazole nucleoside derivatives. PubMed: Efficient synthesis of 3H-imidazo[4,5-b]pyridines from malononitrile and 5-amino-4-(cyanoformimidoyl)imidazoles. PubMed: Solid-phase synthesis of 4(1H)-quinolone and pyrimidine derivatives based on a new scaffold-polymer-bound cyclic malonic acid ester. PubMed: (4R,5S)/(4S,5R)-4,5-Bis(4-hydroxyphenyl)-2-imidazolines: ligands for the estrogen receptor with a novel binding mode. PubMed: [Synthesis of spin labeled analogue of podophyllotoxin glycoside]. PubMed: Facile synthesis of 9-substituted 9-deazapurines as potential purine nucleoside phosphorylase inhibitors. PubMed: Nucleosteroids: carbocyclic nucleoside analogs of androst-4-en-17 beta-ol. PubMed: Convenient synthesis of 4,6-di-O-benzyl-myo-inositol and myo-inositol 1,3,5-orthoesters. PubMed: Synthesis of some biologically active agents derived from thieno[2,3-d]pyrimidine derivatives. PubMed: Bicyclic [b]-heteroannelated pyridazine derivatives. Part 5. Synthesis of some triazolo[4,3-b]pyridazine and pyridazino[6,1-c]triazine derivatives as potential benzodiazepine receptor ligands. PubMed: Synthesis of non-nucleoside analogs of toyocamycin, sangivamycin, and ++thiosangivamycin: influence of various 7-substituents on antiviral activity. PubMed: Synthesis of thiazole-4-carboxamide-adenine difluoromethylenediphosphonates substituted with fluorine at C-2' of the adenosine. PubMed: The reactions of pindolol, mepindolol, carazolol, and related model compounds with triethyl orthoformate: pathways and products of a new colour reaction. PubMed: Synthesis and antiviral activity of carbocyclic analogues of 2'-deoxyribofuranosides of 2-amino-6-substituted-purines and of 2-amino-6-substituted-8-azapurines. PubMed: Synthesis of 5,11-methenyltetrahydrohomofolate and its antifolate activity in vitro. PubMed: Synthesis of dicytidylyl-(3'-5')-1,2-di(adenosin-N6-yl)ethane and dicytidylyl-(3'-5')-1,4-di(adenosin-N6-yl)butane: covalently joined terminals of two transfer ribonucleic acids and their behavior toward snake venom phosphodiesterase. PubMed: Facile syntheses of 1,2,4-triazole and s-triazine glycosides from glycosyl isothiocyanates. PubMed: Model membranes for the study of active transport phenomena. PubMed: Synthesis and pharmacological properties of some 1-aryl-4(1H)-pyrido(2,3-d)pyrimidones.