pomolic acid

CAS: 13849-91-7 C30 H48 O4 MW: 472.70936000

Identification

Namepomolic acid
CAS Number13849-91-7
FDA UNII60HAB1ZK1T
Molecular FormulaC30 H48 O4
Molecular Weight472.70936000
Nikkaji NumberJ14.871G

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Soluble in water, 0.00396 mg/L @ 25 °C (est)

No sensory data available

Safety Information

Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorynatural substances and extractives
Recommendation for pomolic acid usage levels up tonot for fragrance use.
Recommendation for pomolic acid flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

hyptis capitata rosa woodsii

Synonyms

(1R,2R,4aS,6aR,6aS,6bR,8aR,10S,12aR,14bS)-1,10- dihydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid PubMed: [Apoptosis as the basic mechanism of cytotoxic action of ursolic and pomolic acids in glioma cells]. PubMed: Antitumor‑ and apoptosis‑inducing effects of pomolic acid against SK‑MEL‑2 human malignant melanoma cells are mediated via inhibition of cell migration and sub‑G1 cell cycle arrest. PubMed: Pomolic acid induces apoptosis and inhibits multidrug resistance protein MRP1 and migration in glioblastoma cells. PubMed: Anti-hepatitis, antioxidant activities and bioactive compounds of Dracocephalum heterophyllum extracts. PubMed: The Potential of Triterpenoids from Loquat Leaves (Eriobotrya japonica) for Prevention and Treatment of Skin Disorder. PubMed: Pomolic acid suppresses HIF1α/VEGF-mediated angiogenesis by targeting p38-MAPK and mTOR signaling cascades. PubMed: Pomolic Acid Inhibits Invasion of Breast Cancer Cells Through the Suppression of CXC Chemokine Receptor Type 4 Expression. Buyun Kim, Ji-Hun Kim, Byoungduck Park. PubMed: Suppression of MMP-9 and FAK expression by pomolic acid via blocking of NF-κB/ERK/mTOR signaling pathways in growth factor-stimulated human breast cancer cells. PubMed: Pomolic acid inhibits metastasis of HER2 overexpressing breast cancer cells through inactivation of the ERK pathway. PubMed: Chemical characterization of the main bioactive constituents from fruits of Ziziphus jujuba. PubMed: Secondary Metabolites from Leaves of Manilkara subsericea (Mart.) Dubard. PubMed: [Chemical constituents from medical and edible plants of Rosa roxburghii]. PubMed: Pomolic Acid Inhibits Invasion of Breast Cancer Cells Through the Suppression of CXC Chemokine Receptor Type 4 Expression. PubMed: Isolation, characterization, and anthelminthic activities of a novel dichapetalin and other constituents of Dichapetalum filicaule. PubMed: [Triterpene constituents from Rosa cymosa Tratt]. PubMed: [Determination of five triterpenic acids from Salvia chinensis of different parts by RP-HPLC-PDA]. PubMed: Catunarosides I-L, four new triterpenoid saponins from the stem bark of Catunaregam spinosa. PubMed: Pharmacogenomic Characterization of Cytotoxic Compounds from Salvia officinalis in Cancer Cells. PubMed: Cytotoxic compounds from the fruits of Uapaca togoensis towards multifactorial drug-resistant cancer cells. PubMed: [Chemical constituents from roots of Rubus parvifolius]. PubMed: Antiulcer activity of the ethanolic extract and ethyl acetate fraction of the leaves of Markhamia tomentosa in rats. PubMed: Triterpenoids from the fruits and leaves of the blackberry (Rubus allegheniensis) and their inhibitory activities on foam cell formation in human monocyte-derived macrophage. PubMed: Triterpene saponins from the roots of Ilex asprella. PubMed: Hepatoprotective triterpenes from traditional Tibetan medicine Potentilla anserina. PubMed: [Isolation of pomolic acid from Chamaenerion angustifolium and evaluation of its genotoxicity by microbiological tests]. PubMed: Plant extracts inhibit ADP-induced platelet activation in humans: their potential therapeutic role as ADP antagonists. PubMed: Protein tyrosine phosphatase 1B inhibitory activities of ursane- and lupane-type triterpenes from Sorbus pohuashanensis. PubMed: [Chemical constituents from the root of Ilex cornuta]. PubMed: Triterpenoids from Fragaria ananassa calyx and their inhibitory effects on melanogenesis in B16-F10 mouse melanoma cells. PubMed: Sibiricasaponins A-E, five new triterpenoid saponins from the aerial parts of Polygala sibirica L. PubMed: Pomolic acid induces apoptosis in SK-OV-3 human ovarian adenocarcinoma cells through the mitochondrial-mediated intrinsic and death receptor-induced extrinsic pathways. PubMed: Simultaneous determination of seven major triterpenoids in Pyrola decorata H. Andres by LC-MS method. PubMed: [Non-anthraquinones constituents from the roots of Knoxia valerianoides]. PubMed: New flavane gallates isolated from the leaves of Plicosepalus curviflorus and their hypoglycemic activity. PubMed: (24S)-ergostane-3β,5α,6β-triol from Hedyotis chrysotricha with inhibitory activity on migration of SK-HEP-1 human hepatocarcinoma cells. PubMed: Analgesic and anti-inflammatory activities of the methanol extract of Elaeagnus oldhamii Maxim. in mice. PubMed: Triterpenes from Callicarpa integerrima Champ. PubMed: Pomolic acid, triterpenoid isolated from Licania pittieri, as competitive antagonist of ADP-induced aggregation of human platelets. PubMed: Anticancer properties of pomolic acid-induced AMP-activated protein kinase activation in MCF7 human breast cancer cells. PubMed: LC-UV assay method and UPLC/Q-TOF-MS characterisation of saponins from Ilex paraguariensis A. St. Hil. (mate) unripe fruits. PubMed: [Anti-bacteria activity of Puraboeo rutescens and Lysionotus pauciflorus]. PubMed: [Studies on the chemical constituents from the leave of Paulownia tomentosa]. PubMed: Triterpenoids isolated from Zizyphus jujuba inhibit foam cell formation in macrophages. PubMed: Lignans and other constituents from the roots of the Vietnamese medicinal plant Pseuderanthemum palatiferum. PubMed: Pomolic acid of Licania pittieri elicits endothelium-dependent relaxation in rat aortic rings. PubMed: [Studies on the chemical constituents of Callicarpa kochiana]. PubMed: Antiprotozoal activities of some constituents of Markhamia tomentosa (Bignoniaceae). PubMed: A new natural azulene-type pigment from Oreocnide frutescens. PubMed: Antifibrotic activity of triterpenoids from the aerial parts of Euscaphis japonica on hepatic stellate cells. PubMed: Study on determination of pentacyclic triterpenoids in Chaenomeles by HPLC-ELSD. PubMed: Scuteflorins A and B, dihydropyranocoumarins from Scutellaria lateriflora. PubMed: Stimulation of glucose uptake by triterpenoids from Weigela subsessilis. PubMed: Pentacyclic triterpenoids from the aerial parts of Lantana camara and their nematicidal activity. PubMed: Spathoside, a cerebroside and other antibacterial constituents of the stem bark of Spathodea campanulata. PubMed: Aldose-reductase- and protein-glycation-inhibitory principles from the whole plant of Duchesnea chrysantha. PubMed: Anti-inflammatory and apoptotic activities of pomolic acid isolated from Cecropia pachystachya. PubMed: New pomolic acid triterpene glycosides from Zygophyllum eichwaldii. PubMed: [Studies on triterpenoid constituents in leaf of Ilex pernyi]. PubMed: 1H and 13C NMR spectral data of new saponins from Cordia piauhiensis. PubMed: Pomolic acid-induced apoptosis in cells from patients with chronic myeloid leukemia exhibiting different drug resistance profile. PubMed: Production of triterpene acids by cell suspension cultures of Olea europaea. PubMed: [Triterpenes from herb of Potentilla chinesis]. PubMed: [Studies on triterpenoids from Potentilla chinensis]. PubMed: Trypanocidal activity of triterpenes from Arrabidaea triplinervia and derivatives. PubMed: Triterpenes from natural and transformed roots of Plocama pendula. PubMed: Potential cancer chemopreventive agents from Arbutus unedo. PubMed: Anti-complementary activity of ursane-type triterpenoids from Weigela subsessilis. PubMed: Pomolic acid may overcome multidrug resistance mediated by overexpression of anti-apoptotic Bcl-2 proteins. PubMed: [Triterpenes from root of Rhaponticum uniflorum]. PubMed: Two new triterpenoid saponins from Sarcandra glabra. PubMed: Inhibitory effect on TNF-alpha-induced IL-8 production in the HT29 cell of constituents from the leaf and stem of Weigela subsessilis. PubMed: Characterization of two minor saponins from Cordia piauhiensis by 1H and 13C NMR spectroscopy. PubMed: Pomolic acid triggers mitochondria-dependent apoptotic cell death in leukemia cell line. PubMed: Antiproliferative constituents from Umbelliferae plants VII. Active triterpenes and rosmarinic acid from Centella asiatica. PubMed: Triterpenoids from Brazilian Ilex species and their in vitro antitrypanosomal activity. PubMed: Phenolic compounds obtained from stems of Couepia ulei with the potential to induce quinone reductase. PubMed: Triterpene acids from the leaves of Perilla frutescens and their anti-inflammatory and antitumor-promoting effects. PubMed: New anthracene derivatives from Coussarea macrophylla. PubMed: [Chemical constituents from the fruit of Rosa bella Rehd. et Wils]. PubMed: Glycosides from the leaves of Ilex hylonoma. PubMed: Antimicrobial triterpenes from Debregeasia salicifolia. PubMed: Proposed active constituents of Dipladenia martiana. PubMed: [Isolation and identification of Triterpenoid compounds in the fruits of Chaenomeles lagenaria (Loisel.) Koidz]. PubMed: [Chemical constituents of the stem and root of Syzygium buxifolium Hook. Et Arn]. PubMed: Cytotoxic triterpene acids from the Peruvian medicinal plant Polylepis racemosa. PubMed: Triterpene saponins from Randia formosa. PubMed: Triterpenoid saponins from Ilex latifolia. PubMed: Anti-AIDS agents. 30. Anti-HIV activity of oleanolic acid, pomolic acid, and structurally related triterpenoids. PubMed: Triterpene saponins from Scabiosa rotata. PubMed: Triterpenoids from Acaena pinnatifida R. et P. PubMed: Mazusaponins I-IV, triterpene saponins from Mazus miquelii. PubMed: [Studies on the constituents of Leucoseptrum stellipillum]. PubMed: Cytotoxic triterpenes from a Chinese medicine, Goreishi.