germacrone 4,5-epoxide
Identification
| Name | germacrone 4,5-epoxide |
| CAS Number | 92691-35-5 |
| FDA UNII | Search |
| Molecular Formula | C15 H22 O2 |
| Molecular Weight | 234.33874000 |
| Nikkaji Number | J2.763.053G |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Soluble in | water, 10.65 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for germacrone 4,5-epoxide usage levels up to | not for fragrance use. |
| Recommendation for germacrone 4,5-epoxide flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
(1S,6Z,10S)-6,10-
dimethyl-3-propan-2-ylidene-11-oxabicyclo[8.1.0]undec-6-en-4-one
PubMed:
Cytotoxicity and inhibition of leukemic cell proliferation by sesquiterpenes from rhizomes of Mah-Lueang (Curcuma cf. viridiflora Roxb.).
PubMed:
Cytotoxic constituents from the rhizomes of Curcuma zedoaria.
PubMed:
Suppression of Inflammatory cytokine production by ar-Turmerone isolated from Curcuma phaeocaulis.
PubMed:
Transannular cyclization of (4S,5S)-germacrone-4,5-epoxide under basic conditions to yield eudesmane-type sesquiterpenes.
PubMed:
Stability studies of antiandrogenic compounds in Curcuma aeruginosaâ
Roxb. extract.
PubMed:
Quantitative analysis and discrimination of steamed and non-steamed rhizomes of Curcuma wenyujin by GC-MS and HPLC.
PubMed:
Structural diversity from the transannular cyclizations of natural germacrone and epoxy derivatives: a theoretical-experimental study.
PubMed:
Simultaneous determination of multiple sesquiterpenes in Curcuma wenyujin herbal medicines and related products with one single reference standard.
PubMed:
Transannular cyclization of (4S,5S)-germacrone-4,5-epoxide into guaiane and secoguaiane-type sesquiterpenes.
PubMed:
Compounds isolated from Curcuma aromatica Salisb. inhibit human P450 enzymes.
PubMed:
Essential oil constituents from Japanese and Indian Curcuma aromatica rhizomes.